• 1. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 2. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 4. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 5. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Professional Introduction to (4-Bromo-1H-pyrazol-1-yl)acetic Acid (CAS No. 82231-53-6)

(4-Bromo-1H-pyrazol-1-yl)acetic acid, with the CAS number 82231-53-6, is a significant compound in the field of pharmaceutical and chemical research. This compound belongs to the pyrazole derivatives, a class of heterocyclic compounds that have garnered considerable attention due to their diverse biological activities and potential therapeutic applications. The presence of a bromine substituent at the 4-position of the pyrazole ring and the acetic acid moiety at the 1-position endows this molecule with unique chemical properties that make it a valuable scaffold for drug discovery and development.

The< strong>pyrazole core is known for its stability and ability to engage in various hydrogen bonding interactions, making it an ideal platform for designing molecules that can interact with biological targets. The introduction of a< strong>bromine atom at the 4-position enhances the electrophilicity of the ring, facilitating further functionalization through cross-coupling reactions such as Suzuki-Miyaura, Buchwald-Hartwig, and Heck couplings. These reactions are pivotal in constructing more complex molecular architectures, enabling the synthesis of novel drug candidates with tailored properties.

(4-Bromo-1H-pyrazol-1-yl)acetic acid has been extensively studied in recent years for its potential applications in medicinal chemistry. One of the most compelling areas of research involves its use as a precursor in the synthesis of kinase inhibitors. Kinases are enzymes that play a crucial role in cell signaling pathways, and their dysregulation is often associated with various diseases, including cancer. By targeting kinases, it is possible to modulate these pathways and restore normal cellular function.

Recent studies have highlighted the importance of< strong>pyrazole derivatives in developing kinase inhibitors. For instance, modifications of the pyrazole core have led to the discovery of compounds that exhibit potent inhibitory activity against specific kinases. The acetic acid moiety in< strong>(4-Bromo-1H-pyrazol-1-yl)acetic acid provides a handle for further derivatization, allowing chemists to optimize potency, selectivity, and pharmacokinetic properties. This flexibility has made it a preferred building block for structure-based drug design.

In addition to kinase inhibitors, (4-Bromo-1H-pyrazol-1-yl)acetic acid has shown promise in other therapeutic areas. Its ability to act as a scaffold for designing molecules with anti-inflammatory, antimicrobial, and antiviral properties has been explored by several research groups. The bromine substituent at the 4-position of the pyrazole ring allows for easy introduction of additional functional groups through metal-catalyzed reactions, enabling the creation of diverse libraries of compounds for high-throughput screening.

The synthesis of< strong>(4-Bromo-1H-pyrazol-1-yl)acetic acid can be achieved through multiple routes, each offering distinct advantages depending on the desired scale and purity requirements. One common approach involves the bromination of a pre-existing pyrazole derivative followed by carboxylation at the 1-position. Alternatively, direct functionalization strategies can be employed using palladium or copper catalysts to introduce both bromine and acetic acid moieties in a single step.

The chemical properties of< strong>(4-Bromo-1H-pyrazol-1-yl)acetic acid make it an excellent candidate for further derivatization using various organic transformations. For example, nucleophilic aromatic substitution reactions can be used to replace the bromine atom with other functional groups, expanding the scope of possible derivatives. Additionally, condensation reactions with aldehydes or ketones can yield hydrazides or esters, which are useful intermediates in drug synthesis.

The pharmacological evaluation of derivatives derived from< strong>(4-Bromo-1H-pyrazol-1-yl)acetic acid has revealed several promising candidates with therapeutic potential. In preclinical studies, some derivatives have demonstrated efficacy in inhibiting tumor growth and reducing inflammation without significant side effects. These findings have spurred further research into optimizing these compounds for clinical use.

The role of computational chemistry in designing< strong>pyrazole derivatives, including< strong>(4-Bromo-1H-pyrazol-1-yl)acetic acid, cannot be overstated. Molecular modeling techniques allow researchers to predict how these compounds will interact with biological targets at a molecular level. This information is crucial for guiding synthetic efforts and improving drug candidates' pharmacological profiles.

In conclusion,< strong>(4-Bromo-1H-pyrazol-1-yl)acetic acid (CAS No. 82231-53-6) is a versatile compound with significant potential in pharmaceutical research. Its unique structure and reactivity make it an invaluable building block for developing novel therapeutics targeting various diseases. As research continues to uncover new applications for this compound and its derivatives, its importance in medicinal chemistry is likely to grow even further.

• 16034-48-3(2-(1H-Pyrazol-1-Yl)Acetic Acid)
• 1177354-50-5(4-Bromo-1H-pyrazole-1-acetamide)
• 925146-35-6(3-(4-bromo-1H-pyrazol-1-yl)propanoic acid)
• 1007550-84-6(2-(4-Bromo-1h-pyrazol-1-yl)acetaldehyde)
• 1199773-67-5(Tert-Butyl 2-(4-bromo-1H-pyrazol-1-yl)acetate)
• 214614-81-0(2-(4-bromo-1H-pyrazol-1-yl)ethan-1-ol)
• 847818-49-9(4-bromo-1-(2-methoxyethyl)-1H-pyrazole)
• 1072944-71-8(Methyl 2-(4-bromo-1H-pyrazol-1-yl)acetate)
• 51292-42-3(2-(4-Bromo-1H-pyrazol-1-yl)propanoic acid)
• 82231-58-1(Ethyl 2-(4-bromo-1H-pyrazol-1-yl)acetate)