• 1. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 2. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 3. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 4. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 5. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182

Introduction to 6-(4-Methylpiperazin-1-yl)pyridin-3-amine hydrochloride (CAS No. 82205-57-0)

6-(4-Methylpiperazin-1-yl)pyridin-3-amine hydrochloride, identified by its CAS number 82205-57-0, is a significant compound in the field of pharmaceutical chemistry. This compound belongs to the class of piperazine derivatives, which are widely recognized for their diverse biological activities and applications in drug development. The hydrochloride salt form enhances its solubility and stability, making it a valuable intermediate in synthetic chemistry and a potential candidate for further pharmacological investigation.

The molecular structure of 6-(4-Methylpiperazin-1-yl)pyridin-3-amine hydrochloride consists of a pyridine ring substituted at the 3-position with an amine group, which is further connected to a 4-methylpiperazine moiety. This structural arrangement contributes to its unique chemical properties and biological interactions. The presence of the piperazine ring is particularly noteworthy, as it is a common pharmacophore in many drugs due to its ability to modulate various neurotransmitter systems.

In recent years, there has been growing interest in exploring the therapeutic potential of piperazine derivatives, particularly in the treatment of neurological and psychiatric disorders. The compound 6-(4-Methylpiperazin-1-yl)pyridin-3-amine hydrochloride has been investigated for its potential role in modulating serotonin and dopamine receptors, which are key targets in the management of conditions such as depression, anxiety, and schizophrenia. Preliminary studies suggest that this compound may exhibit properties that could make it useful in developing novel therapeutic agents.

One of the most compelling aspects of 6-(4-Methylpiperazin-1-yl)pyridin-3-amine hydrochloride is its versatility as a building block in medicinal chemistry. Its structural features allow for modifications at multiple sites, enabling chemists to tailor its properties for specific applications. For instance, the amine group at the 3-position of the pyridine ring can be further functionalized to introduce additional pharmacological targets or improve pharmacokinetic profiles.

The synthesis of 6-(4-Methylpiperazin-1-yl)pyridin-3-amine hydrochloride involves several key steps that highlight the expertise required in organic synthesis. The process typically begins with the preparation of a pyridine derivative, followed by nucleophilic substitution reactions to introduce the piperazine moiety. The final step involves converting the free base into its hydrochloride salt, which enhances its stability and solubility. These synthetic routes underscore the compound's importance as a synthetic intermediate and its potential for industrial applications.

Recent advancements in computational chemistry have also contributed to a deeper understanding of the interactions between 6-(4-Methylpiperazin-1-yl)pyridin-3-amine hydrochloride and biological targets. Molecular modeling studies have revealed insights into how this compound binds to receptors and enzymes, providing valuable information for drug design. These computational approaches complement traditional experimental methods and have accelerated the discovery process in pharmaceutical research.

The pharmacological profile of 6-(4-Methylpiperazin-1-yl)pyridin-3-amine hydrochloride is still being elucidated, but early findings suggest promising applications in several therapeutic areas. Its ability to interact with multiple receptor systems makes it a candidate for developing multitarget drugs, which are gaining increasing attention due to their potential for synergistic effects and reduced side effects. Furthermore, its structural similarity to known drugs suggests that it may exhibit similar or improved pharmacological properties.

In conclusion, 6-(4-Methylpiperazin-1-yl)pyridin-3-amine hydrochloride (CAS No. 82205-57-0) is a versatile and intriguing compound with significant potential in pharmaceutical research. Its unique structure, combined with its biological activities, makes it a valuable tool for drug discovery and development. As research continues to uncover new applications and synthetic strategies, this compound is poised to play an important role in addressing unmet medical needs.

• 16019-67-3( )
• 126824-12-2(6-(4-methyl-1-piperazinyl)-2,3-Pyridinediamine)
• 34392-84-2(N2,N2-Diethyl-2,5-pyridinediamine)
• 119285-06-2(3-Pyridinamine,6-(1-piperazinyl)-)
• 773879-29-1(6-[4-(2-propen-1-yl)-1-piperazinyl]-3-Pyridinamine)
• 129394-11-2(1-(2-Pyridyl)piperazine monohydrochloride)
• 55403-35-5(6-(4-Methyl-1-piperazinyl)-3-pyridinamine)
• 5028-17-1(2-(4-Methyl-piperazin-1-yl)-pyridin-3-ylamine)
• 112940-58-6(Benzenamine, 4-[4-(2-pyridinyl)-1-piperazinyl]-)
• 87394-62-5(2-(piperazin-1-yl)pyridin-3-amine)