• 1. Aggregation, pretransitional behavior, and optical properties in the isotropic phase of lyotropic chromonic liquid crystals studied in high magnetic fields
  Tanya Ostapenko,Peter J. Collings,Samuel N. Sprunt,J. T. Gleeson Soft Matter, 2013,9, 9487-9498
• 2. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
• 3. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
  R. M. Pemberton,J. P. Hart,T. T. Mottram Analyst, 2001,126, 1866-1871
• 4. An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction?
  Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296
• 5. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804

Research Brief on Ethyl 2-mercapto-4-methylpyrimidine-5-carboxylate (CAS: 81633-30-9) in Chemical Biology and Pharmaceutical Applications

Ethyl 2-mercapto-4-methylpyrimidine-5-carboxylate (CAS: 81633-30-9) is a pyrimidine derivative that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound serves as a key intermediate in the synthesis of various biologically active molecules, including potential drug candidates. Its unique structural features, such as the mercapto and carboxylate functional groups, make it a valuable building block for the development of novel therapeutic agents. Recent studies have explored its role in the synthesis of kinase inhibitors, antimicrobial agents, and other pharmacologically relevant compounds.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers investigated the use of ethyl 2-mercapto-4-methylpyrimidine-5-carboxylate as a precursor for the development of selective kinase inhibitors. The study demonstrated that modifications to the pyrimidine core could yield compounds with high affinity for specific kinase targets, offering potential therapeutic benefits in cancer and inflammatory diseases. The researchers employed a combination of computational modeling and synthetic chemistry to optimize the compound's structure, resulting in improved pharmacokinetic properties and target specificity.

Another notable application of ethyl 2-mercapto-4-methylpyrimidine-5-carboxylate was highlighted in a 2022 study published in Bioorganic & Medicinal Chemistry Letters. The research team utilized this compound as a starting material for the synthesis of novel antimicrobial agents. The resulting derivatives exhibited potent activity against a range of Gram-positive and Gram-negative bacteria, including multidrug-resistant strains. The study emphasized the importance of the mercapto group in enhancing the compounds' binding affinity to bacterial targets, thereby improving their efficacy.

Recent advancements in synthetic methodologies have also facilitated the efficient production of ethyl 2-mercapto-4-methylpyrimidine-5-carboxylate. A 2023 report in Organic Process Research & Development described a scalable and cost-effective synthesis route for this compound, which is critical for its industrial application. The optimized process involved a one-pot reaction with high yield and purity, addressing previous challenges related to scalability and environmental impact.

In addition to its role in drug discovery, ethyl 2-mercapto-4-methylpyrimidine-5-carboxylate has been explored in chemical biology for the development of probes and tools. A 2021 study in Chemical Communications demonstrated its utility in the design of fluorescent probes for detecting reactive oxygen species (ROS) in cellular systems. The probe's ability to selectively interact with ROS highlights the compound's potential in diagnostic and imaging applications.

Looking ahead, ongoing research is expected to further elucidate the therapeutic potential of ethyl 2-mercapto-4-methylpyrimidine-5-carboxylate and its derivatives. Collaborative efforts between academia and industry are likely to drive innovations in its synthesis and application, paving the way for new breakthroughs in chemical biology and pharmaceutical development. The compound's versatility and promising biological activity make it a focal point for future studies in these fields.

• 774-07-2(Ethyl 4-Amino-2-mercaptopyrimidine-5-carboxylate)
• 2111662-23-6(5-Pyrimidinecarboxylic acid, 1,2-dihydro-2-thioxo-, methyl ester)
• 1378506-17-2(2-sulfanylpyrimidine-5-carboxylic acid)
• 858447-44-6(Ethyl 2-thioxo-1,2-dihydropyrimidine-5-carboxylate)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)