Cas no 81597-51-5 (5-bromo-4-methylthiophene-2-sulfonyl chloride)
5-Bromo-4-methylthiophene-2-sulfonyl chloride is a versatile sulfonylating reagent widely used in organic synthesis and pharmaceutical intermediates. Its key advantages include high reactivity as an electrophile, enabling efficient sulfonylation of amines, alcohols, and other nucleophiles. The bromo and methyl substituents enhance its utility in further functionalization, such as cross-coupling reactions, while the thiophene backbone contributes to stability and regioselectivity. This compound is particularly valuable in medicinal chemistry for constructing sulfonamide derivatives, a common pharmacophore. It is typically handled under anhydrous conditions due to its moisture sensitivity, ensuring optimal performance in synthetic applications.
81597-51-5 structure
Product Name:5-bromo-4-methylthiophene-2-sulfonyl chloride
CAS No:81597-51-5
MF:C5H4BrClO2S2
MW:275.571057319641
CID:1804199
PubChem ID:71683547
Update Time:2025-11-01
5-bromo-4-methylthiophene-2-sulfonyl chloride Chemical and Physical Properties
Names and Identifiers
-
- 2-Thiophenesulfonyl chloride, 5-bromo-4-methyl-
- 5-bromo-4-methyl-2-Thiophenesulfonyl chloride
- 5-bromo-4-methylthiophene-2-sulfonyl chloride
- RRMFMKFGHNRQPZ-UHFFFAOYSA-N
- DA-37734
- EN300-102314
- 5-bromo-4-methylthiophene-2-sulfonylchloride
- AT16668
- CS-0491430
- 81597-51-5
- SCHEMBL4534390
- AKOS016037677
-
- Inchi： 1S/C5H4BrClO2S2/c1-3-2-4(10-5(3)6)11(7,8)9/h2H,1H3
- InChI Key： RRMFMKFGHNRQPZ-UHFFFAOYSA-N
- SMILES： BrC1=C(C)C=C(S1)S(=O)(=O)Cl
Computed Properties
- Exact Mass: 273.85246g/mol
- Monoisotopic Mass: 273.85246g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 11
- Rotatable Bond Count: 1
- Complexity: 235
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 3.3
- Topological Polar Surface Area: 70.8?2
5-bromo-4-methylthiophene-2-sulfonyl chloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1562097-1g |
5-Bromo-4-methylthiophene-2-sulfonyl chloride |
81597-51-5 | 98% | 1g |
￥3516.00 | 2024-07-28 | |
| Enamine | EN300-102314-0.05g |
5-bromo-4-methylthiophene-2-sulfonyl chloride |
81597-51-5 | 95% | 0.05g |
$202.0 | 2023-10-28 | |
| Enamine | EN300-102314-0.1g |
5-bromo-4-methylthiophene-2-sulfonyl chloride |
81597-51-5 | 95% | 0.1g |
$301.0 | 2023-10-28 | |
| Enamine | EN300-102314-0.25g |
5-bromo-4-methylthiophene-2-sulfonyl chloride |
81597-51-5 | 95% | 0.25g |
$431.0 | 2023-10-28 | |
| Enamine | EN300-102314-0.5g |
5-bromo-4-methylthiophene-2-sulfonyl chloride |
81597-51-5 | 95% | 0.5g |
$679.0 | 2023-10-28 | |
| Enamine | EN300-102314-1.0g |
5-bromo-4-methylthiophene-2-sulfonyl chloride |
81597-51-5 | 95% | 1g |
$871.0 | 2023-06-10 | |
| Enamine | EN300-102314-2.5g |
5-bromo-4-methylthiophene-2-sulfonyl chloride |
81597-51-5 | 95% | 2.5g |
$1707.0 | 2023-10-28 | |
| Enamine | EN300-102314-5.0g |
5-bromo-4-methylthiophene-2-sulfonyl chloride |
81597-51-5 | 95% | 5g |
$2525.0 | 2023-06-10 | |
| Enamine | EN300-102314-10.0g |
5-bromo-4-methylthiophene-2-sulfonyl chloride |
81597-51-5 | 95% | 10g |
$3746.0 | 2023-06-10 | |
| 1PlusChem | 1P00G97X-50mg |
5-bromo-4-methyl-2-Thiophenesulfonyl chloride |
81597-51-5 | 95% | 50mg |
$260.00 | 2025-02-27 |
5-bromo-4-methylthiophene-2-sulfonyl chloride Related Literature
-
Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
-
Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
-
Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
-
J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
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