• 1. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 2. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 3. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 4. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes Nitrophenyl ethers

Introduction to 5-bromo-1,3-dimethoxy-2-nitroBenzene (CAS No. 815632-47-4)

5-bromo-1,3-dimethoxy-2-nitroBenzene, identified by its Chemical Abstracts Service (CAS) number 815632-47-4, is a specialized organic compound that has garnered significant attention in the field of medicinal chemistry and synthetic organic chemistry. This heterocyclic aromatic molecule features a benzene ring substituted with a bromine atom, two methoxy groups, and a nitro group, making it a versatile intermediate for the synthesis of more complex pharmacologically active agents. The unique structural arrangement of these functional groups imparts distinct reactivity patterns that make it a valuable building block in the development of novel therapeutic compounds.

The compound's molecular structure, characterized by a nitro group at the 2-position and bromine as well as methoxy substituents at the 1 and 3 positions, contributes to its utility in cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings. These reactions are pivotal in constructing biaryl frameworks, which are prevalent in many drugs on the market today. The presence of the nitro group further enhances its reactivity, allowing for reduction to an amine or further functionalization via diazotization reactions. Such transformations open up multiple pathways for medicinal chemists to explore new chemical space for drug discovery.

In recent years, 5-bromo-1,3-dimethoxy-2-nitroBenzene has been explored in the context of developing small-molecule inhibitors targeting various biological pathways. For instance, studies have demonstrated its potential utility in generating derivatives that interact with enzymes involved in cancer metabolism. The dimethoxy and nitro substituents provide opportunities for fine-tuning electronic properties and hydrogen bonding capabilities, which are critical for achieving high binding affinity to biological targets. Furthermore, the bromine atom serves as an excellent handle for further derivatization via palladium-catalyzed reactions, enabling the construction of diverse molecular architectures.

One notable application of 5-bromo-1,3-dimethoxy-2-nitroBenzene is in the synthesis of kinase inhibitors. Kinases are enzymes that play a crucial role in cell signaling pathways and are often dysregulated in diseases such as cancer. By leveraging the compound's reactive sites, researchers have been able to develop novel inhibitors that disrupt aberrant signaling cascades. For example, modifications at the 1-position using different alkyl or aryl groups have led to compounds with enhanced selectivity against specific kinases, reducing off-target effects. This underscores the importance of 5-bromo-1,3-dimethoxy-2-nitroBenzene as a scaffold for generating next-generation therapeutics.

The pharmaceutical industry has also shown interest in 5-bromo-1,3-dimethoxy-2-nitroBenzene for its potential in creating antimicrobial agents. The structural motifs present in this compound can be modified to develop molecules capable of inhibiting bacterial or fungal growth. Recent research has highlighted its role in generating derivatives with potent activity against drug-resistant pathogens. The combination of electron-withdrawing nitro and electron-donating methoxy groups can modulate lipophilicity and metabolic stability, key factors in antimicrobial drug design. This has spurred further investigation into optimizing synthetic routes to improve yields and purity of 5-bromo-1,3-dimethoxy-2-nitroBenzene derivatives.

Synthetic methodologies for preparing 5-bromo-1,3-dimethoxy-2-nitroBenzene have also seen advancements. Traditional approaches often involve multi-step sequences starting from commercially available precursors like nitrobenzene or bromobenzene derivatives. However, newer methods have focused on more efficient one-pot or sequential reactions that minimize byproducts and improve overall atom economy. These innovations not only enhance scalability but also reduce costs associated with purification processes. Additionally, green chemistry principles have been incorporated into synthetic protocols to minimize hazardous waste generation while maintaining high reaction efficiencies.

The spectroscopic and analytical characterization of 5-bromo-1,3-dimethoxy-2-nitroBenzene is another critical aspect that ensures its identity and purity before use in pharmaceutical applications. Techniques such as nuclear magnetic resonance (NMR) spectroscopy—including proton (1H) and carbon (13C) NMR—along with mass spectrometry (MS) provide definitive structural confirmation. Infrared (IR) spectroscopy aids in identifying functional groups present within the molecule. High-performance liquid chromatography (HPLC) or gas chromatography-mass spectrometry (GC-MS) are employed for purity assessment and quantification purposes during quality control processes.

The safety profile of 5-bromo-1,3-dimethoxy-2-nitroBenzene is another consideration when evaluating its suitability for industrial applications. While it is not classified as hazardous under standard conditions storage conditions should be maintained away from heat sources due to potential thermal instability associated with nitroaromatic compounds general handling precautions include wearing appropriate personal protective equipment (PPE). Proper ventilation should be ensured when working with this compound indoors given possible inhalation hazards if dust or vapors become airborne.

In conclusion,5-bromo-1 3 dimethoxy 2 nitroBenzene CAS No 815632 47 4 represents an important intermediate with broad utility across multiple sectors including pharmaceuticals agrochemicals materials science among others Its unique structural features offer opportunities through diverse synthetic transformations leading toward novel functional materials bioactive molecules The ongoing research into optimizing synthesis methods improving safety protocols expanding biological applications continues solidify position key component modern chemical industry Forward future development work likely uncover even greater potential this versatile compound

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