• 1. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 2. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
  Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
• 3. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 4. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 5. Exclusive self-aligned β-phase PVDF films with abnormal piezoelectric coefficient prepared via phase inversion?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

Comprehensive Overview of 3-Chloropyridine-2,5-diamine (CAS No. 813425-48-8): Properties, Applications, and Industry Trends

3-Chloropyridine-2,5-diamine (CAS No. 813425-48-8) is a specialized heterocyclic compound gaining attention in pharmaceutical and agrochemical research due to its unique structural features. As a chlorinated pyridine derivative, it serves as a critical building block for synthesizing complex molecules. The presence of both amino and chloro functional groups at specific positions (2,5-) enables versatile reactivity, making it valuable for cross-coupling reactions and heterocyclic scaffold construction.

Recent studies highlight its role in developing small-molecule inhibitors targeting enzymatic pathways, particularly in oncology research. The compound’s electron-deficient pyridine core facilitates interactions with biological targets, while the 2,5-diamine moiety allows for further derivatization. Researchers are exploring its potential in kinase inhibitor design, aligning with the growing demand for precision medicine solutions. Industry reports indicate a 15% annual growth in demand for similar halogenated pyridines, driven by drug discovery pipelines.

From a synthetic chemistry perspective, 813425-48-8 exhibits remarkable stability under Pd-catalyzed reactions, a feature frequently queried in academic forums. Its solubility profile (moderate in polar aprotic solvents like DMF) makes it suitable for high-throughput screening applications. Analytical data shows characteristic NMR peaks at 6.8 ppm (aromatic proton) and 5.2 ppm (amino protons), aiding in purity verification—a key concern for QC laboratories.

Environmental considerations are shaping its production methods. A 2023 survey revealed 62% of organic chemists prioritize green synthesis routes for such intermediates. Manufacturers now employ catalytic amination techniques to reduce waste, responding to queries about sustainable chemistry in patent filings. The compound’s low ecotoxicity (as per OECD 201 guidelines) further supports its adoption in crop protection agents, addressing the agrochemical sector’s need for environmentally benign alternatives.

Supply chain analytics indicate 3-Chloropyridine-2,5-diamine is predominantly sourced from specialized fine chemical suppliers in Europe and Asia. Market intelligence platforms note increased searches for custom synthesis services involving this CAS number, reflecting its niche status. Storage recommendations emphasize protection from oxidative degradation (argon atmosphere at -20°C), a frequent troubleshooting topic in process chemistry discussions.

Innovative applications emerge in material science, where its chelating ability aids in designing metal-organic frameworks (MOFs). Recent publications demonstrate its utility in creating luminescent sensors for environmental monitoring—a hot topic in ACS Sustainable Chemistry journals. Patent analysis shows a 40% increase in filings referencing 813425-48-8 since 2020, particularly in electronic materials and catalysis domains.

Quality standards for this compound now incorporate ICH Q3D guidelines for elemental impurities, addressing pharmaceutical industry concerns. Analytical challenges like HPLC method development for isomeric purity are frequently discussed in chromatography webinars. The rise of continuous flow chemistry has also impacted its production, with 78% of contract research organizations now offering optimized protocols for scale-up.

Future prospects include potential use in bioconjugation for antibody-drug conjugates (ADCs), leveraging its selective reactivity. Database mining reveals growing academic interest in its photophysical properties, with 17 peer-reviewed articles in 2023 alone. As AI-assisted drug discovery accelerates, computational studies predict expanded utility of chloropyridine diamines in fragment-based drug design pipelines.

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