• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 3. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 4. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Haloquinolines

Comprehensive Overview of 7-Bromo-8-methylquinoline (CAS No. 809248-61-1): Properties, Applications, and Industry Insights

7-Bromo-8-methylquinoline (CAS No. 809248-61-1) is a halogenated quinoline derivative that has garnered significant attention in pharmaceutical and agrochemical research due to its versatile structural framework. The compound's molecular formula, C₁₀H₈BrN, highlights its bromine-substituted quinoline core, which is pivotal for modulating biological activity. Researchers frequently search for "7-Bromo-8-methylquinoline synthesis" or "CAS 809248-61-1 applications," reflecting its relevance in drug discovery and material science. This article delves into its properties, synthetic routes, and emerging trends aligned with industry demands.

The physicochemical properties of 7-Bromo-8-methylquinoline include a molecular weight of 222.08 g/mol and a melting point range of 120–125°C, making it suitable for controlled reactions in organic synthesis. Its bromine atom enhances reactivity in cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings, which are critical for constructing complex molecules. Queries like "quinoline derivatives in medicinal chemistry" or "8-methylquinoline uses" underscore its role in developing kinase inhibitors or antimicrobial agents. Recent studies also explore its potential in OLED materials, addressing the growing demand for energy-efficient technologies.

From a synthetic perspective, 7-Bromo-8-methylquinoline is typically prepared via bromination of 8-methylquinoline using reagents like N-bromosuccinimide (NBS). Optimizing yield and purity is a common challenge, as noted in searches for "high-purity 809248-61-1 suppliers." The compound's stability under inert atmospheres and compatibility with palladium catalysts further elevate its utility in scalable processes. Innovations in green chemistry, such as solvent-free bromination, align with sustainability trends, a hot topic in 2024.

In pharmaceutical applications, 7-Bromo-8-methylquinoline serves as a precursor for antitumor and antiviral compounds. Its quinoline scaffold is a privileged structure in FDA-approved drugs, driving interest in "quinoline-based drug design." For instance, derivatives of this compound have shown promise in targeting RNA viruses, resonating with post-pandemic research priorities. Additionally, its agrochemical potential—such as in crop protection agents—answers queries like "bromoquinoline pesticides," reflecting cross-industry applicability.

The market landscape for CAS 809248-61-1 is shaped by demand from contract research organizations (CROs) and specialty chemical manufacturers. Regulatory compliance, such as REACH or FDA guidelines, is a recurring concern among buyers searching for "GMP-grade 7-Bromo-8-methylquinoline." Suppliers emphasizing analytical certifications (HPLC, NMR) gain traction, as quality assurance remains paramount. Furthermore, the rise of AI-driven molecular modeling has intensified interest in "quinoline derivatives for virtual screening," positioning this compound as a valuable asset in computational drug discovery.

Future directions for 7-Bromo-8-methylquinoline research include exploring its role in photoactive materials and catalysis. With the global push toward renewable energy, its potential in organic photovoltaics (OPVs) could answer searches like "quinolines in solar cells." Collaborative efforts between academia and industry are crucial to unlocking these applications, ensuring this compound remains at the forefront of innovation.

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