• 1. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 2. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 3. An integrated system for field analysis of Cd(ii) and Pb(ii) via preconcentration using nano-TiO2/cellulose paper composite and subsequent detection with a portable X-ray fluorescence spectrometer?
  Xiaofeng Lin RSC Adv., 2016,6, 9002-9006
• 4. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535
• 5. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinolines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives

Methyl 4-methylquinoline-2-carboxylate: A Comprehensive Overview

Methyl 4-methylquinoline-2-carboxylate, also known by its CAS number 80109-83-7, is a significant compound in the field of organic chemistry. This compound has garnered attention due to its unique structural properties and potential applications in various scientific domains. In this article, we will delve into the details of its structure, synthesis, properties, and recent advancements in its research.

The chemical structure of Methyl 4-methylquinoline-2-carboxylate consists of a quinoline ring system with a methyl group attached at the 4-position and a carboxylate ester group at the 2-position. The quinoline moiety is a bicyclic structure comprising a benzene ring fused to a pyridine ring. This arrangement imparts unique electronic properties to the molecule, making it a valuable component in various chemical reactions and applications.

Recent studies have highlighted the importance of quinoline derivatives in drug discovery and material science. For instance, researchers have explored the potential of Methyl 4-methylquinoline-2-carboxylate as a precursor for synthesizing bioactive compounds with anti-inflammatory and anticancer properties. The methyl group at the 4-position plays a crucial role in modulating the electronic properties of the molecule, which is essential for its biological activity.

In terms of synthesis, Methyl 4-methylquinoline-2-carboxylate can be prepared through various methods, including Friedl?nder synthesis and Skraup synthesis. These methods involve the condensation of appropriate aromatic aldehydes with ketones or other carbonyl compounds under specific reaction conditions. The choice of synthesis method depends on the desired purity and yield of the final product.

The physical properties of Methyl 4-methylquinoline-2-carboxylate are also worth noting. It is typically a crystalline solid with a melting point around 150°C. The compound is sparingly soluble in water but exhibits good solubility in organic solvents such as dichloromethane and ethyl acetate. These properties make it suitable for use in various organic reactions and chromatographic separations.

Recent advancements in computational chemistry have enabled researchers to study the electronic structure and reactivity of Methyl 4-methylquinoline-2-carboxylate in greater detail. Quantum mechanical calculations have revealed that the compound exhibits significant π-electron delocalization across its conjugated system, which contributes to its stability and reactivity. This understanding has paved the way for new applications in areas such as nonlinear optics and electronic materials.

In conclusion, Methyl 4-methylquinoline-2-carboxylate, with its CAS number 80109-83-7, is a versatile compound with promising potential in various scientific fields. Its unique structure, coupled with recent research findings, underscores its importance as a valuable tool in organic chemistry and materials science.

• 16382-15-3(ethyl 5-methyl-1H-indole-2-carboxylate)
• 19575-07-6(Methyl quinoline-2-carboxylate)
• 136831-13-5(Methyl 4-methyl-1H-indole-2-carboxylate)
• 881040-29-5(2,6-dimethyl 1H-indole-2,6-dicarboxylate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)