Cas no 801-52-5 (Porfiromycin)

Porfiromycin is an antibiotic and antitumor agent derived from Streptomyces species, belonging to the mitomycin family. It functions as an alkylating agent, inducing DNA cross-links and inhibiting nucleic acid synthesis, which makes it effective against certain bacterial infections and solid tumors. Its bioreductive activation under hypoxic conditions enhances its selectivity for targeting tumor microenvironments, reducing systemic toxicity. Porfiromycin has been studied for its potential in combination therapies, particularly in treating hypoxic cancer cells resistant to conventional treatments. Its stability and mechanism of action make it a valuable compound for research in oncology and antimicrobial applications.
Porfiromycin structure
Porfiromycin structure
Product Name:Porfiromycin
CAS No:801-52-5
MF:C16H20N4O5
MW:348.353803634644
CID:721718
PubChem ID:13116
Update Time:2025-06-13

Porfiromycin Chemical and Physical Properties

Names and Identifiers

    • Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS)-
    • Porfiromycin
    • Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1
    • 8-Azathioxanthine
    • Methyl MitoMycin C
    • Methylmitomycin
    • N-methylmitomycin C
    • Porfiromycine
    • porphiromycin
    • RegaMycin
    • PORFIROMYCIN [MI]
    • CHEMBL521078
    • Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-1,5-dimethyl-, carbamate (ester)
    • DB06478
    • Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-, (1aS,8S,8aR,8bS)-
    • PORFIROMYCIN [USAN]
    • HY-13730
    • U-14,743
    • 801-52-5
    • AI3-50825
    • PORFIROMYCIN [INN]
    • PORFIROMYCIN [WHO-DD]
    • Q27279527
    • UNII-H1WK901OA6
    • Azirino(2',3':3,4)pyrrolo(1,2-a)-indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-
    • U-14743
    • 6-Amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-1,5-dimethylazirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione carbamate (ester)
    • Porfiromycinum
    • Porfiromicina
    • CHEBI:208611
    • CS-0007759
    • Nsc 56410
    • NS00073289
    • D05572
    • 6-Amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-1,5-dimethyl-azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, carbamate ester
    • NSC-56410
    • DTXSID901024646
    • (amino-methoxy-dimethyl-dioxo-[?]yl)methyl carbamate
    • ENT-50825
    • [(4S,6S,7R,8S)-11-amino-7-methoxy-5,12-dimethyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
    • Porfiromycin [USAN:INN:BAN]
    • Porfiromycin (USAN/INN)
    • Porfiromicina [INN-Spanish]
    • (1AS-(1A.ALPHA.,8.BETA.,8A.ALPHA.,8B.ALPHA.))-6-AMINO-8-(((AMINOCARBONYL)OXY)METHYL)-1,1A,2,8,8A,8B-HEXAHYDRO-8A-METHOXY-1,5-DIMETHYLAZIRINO(2';,3';:3,4)PYRROLO(1,2-A)INDOLE-4,7-DIONE
    • SCHEMBL5046
    • N-METHYLMITOMYCIN C [MI]
    • Porfiromycine [INN-French]
    • Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a- methoxy-1,5-dimethyl-, carbamate (ester)
    • ((1aS,8S,8aR,8bS)-6-amino-8a-methoxy-1,5-dimethyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazirino[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate
    • PORFIROMYCIN [MART.]
    • Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b- hexahydro-8a-methoxy-1,5-dimethyl-,(1aR-(1aalpha,8beta,8aalpha,8balpha))-
    • H1WK901OA6
    • Porfiromycinum [INN-Latin]
    • SMR000528838
    • FT-0673976
    • Azirino[2',3':3,4]pyrrolo[1,2-a]-indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-, (1aS,8S,8aR,8bS)-
    • Profiromycin
    • NCI60_004377
    • Azirino[2',4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a- methoxy-1,5-dimethyl-, carbamate (ester)
    • Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-1,5-dimethyl-, carbamate
    • NCGC00246835-01
    • MLS000766209
    • SCHEMBL5047
    • Azirino[2',4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b- hexahydro-8a-methoxy-1,5-dimethyl-,[1aR-(1a.alpha.,8.beta.,8a.alpha.,8b.alpha.)]-
    • WLN: T D3 B556 BN EN JV MVTTT&J E1 GO1 H1OVZ KZ L1
    • HMS2270B05
    • CHEMBL1983333
    • 6-Amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dionecarbamate (ester)
    • CHEBI:182803
    • Porphyromycin
    • u 14743
    • Neuro_000023
    • BDBM50235885
    • Mitomycin C, N-methyl-
    • (11-amino-7-methoxy-5,12-dimethyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl)methyl carbamate
    • AKOS030254763
    • HRHKSTOGXBBQCB-UHFFFAOYSA-N
    • (6-Amino-8a-methoxy-1,5-dimethyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate #
    • NSC56410
    • (6-Amino-8a-methoxy-1,5-dimethyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl)methyl carbamate
    • Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-1,5-dimethyl-, carbamate (ester)
    • Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-, [1aS-(1a.alpha.,8.beta.,8a.alpha.,8b.alpha.)]-
    • DA-66827
    • Inchi： 1S/C16H20N4O5/c1-6-10(17)13(22)9-7(5-25-15(18)23)16(24-3)14-8(19(14)2)4-20(16)11(9)12(6)21/h7-8,14H,4-5,17H2,1-3H3,(H2,18,23)/t7-,8+,14+,16-,19?/m1/s1
    • InChI Key： HRHKSTOGXBBQCB-VFWICMBZSA-N
    • SMILES： O(C)[C@@]12[C@H](COC(N)=O)C3C(C(=C(C)C(C=3N1C[C@H]1[C@@H]2N1C)=O)N)=O

Computed Properties

  • Exact Mass: 348.14300
  • Monoisotopic Mass: 348.14336975g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 9
  • Heavy Atom Count: 25
  • Rotatable Bond Count: 4
  • Complexity: 787
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 4
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -0.4
  • Topological Polar Surface Area: 128?2

Experimental Properties

  • Density: 1.1924 (rough estimate)
  • Melting Point: 201.25°C (rough estimate)
  • Boiling Point: 482.73°C (rough estimate)
  • Refractive Index: 1.6000 (estimate)
  • PSA: 127.96000
  • LogP: -0.03260
  • Specific Rotation: D25 +275 ±55° (c = 0.1% in methanol); D25 +242 ±100° (c = 0.045% in methanol)

Porfiromycin Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
P689450-1mg
Porfiromycin
 801-52-5
1mg
 $ 265.00 2023-09-06
TRC
P689450-2mg
Porfiromycin
 801-52-5
2mg
 $492.00 2023-05-17
TRC
P689450-5mg
Porfiromycin
 801-52-5
5mg
 $ 1177.00 2023-09-06
TRC
P689450-10mg
Porfiromycin
 801-52-5
10mg
 $ 2036.00 2023-09-06
TRC
P689450-25mg
Porfiromycin
 801-52-5
25mg
 $4649.00 2023-05-17
SHENG KE LU SI SHENG WU JI SHU
sc-476298-1 mg
Porfiromycin,
 801-52-5
1mg
 ￥3,234.00 2023-07-10
SHENG KE LU SI SHENG WU JI SHU
sc-476300-1 mg
Porfiromycin-d3,
 801-52-5
1mg
 ￥3,610.00 2023-07-10
SHENG KE LU SI SHENG WU JI SHU
sc-476300-1mg
Porfiromycin-d3,
 801-52-5
1mg
 ￥3610.00 2023-09-05
SHENG KE LU SI SHENG WU JI SHU
sc-476298-1mg
Porfiromycin,
 801-52-5
1mg
 ￥3234.00 2023-09-05
A2B Chem LLC
AE03294-1mg
Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,(1aS,8S,8aR,8bS)-
 801-52-5
1mg
 $374.00 2024-04-19

Porfiromycin Related Literature

Related Categories

Additional information on Porfiromycin

Porfiromycin (CAS No. 801-52-5): A Comprehensive Overview of Its Applications and Recent Research Findings

Porfiromycin, with the chemical identifier CAS No. 801-52-5, is a compound that has garnered significant attention in the field of pharmaceutical chemistry and biochemistry. This unique molecule, belonging to the class of porphyrin derivatives, exhibits a distinct structure that contributes to its remarkable biological properties. Over the years, extensive research has been conducted to elucidate its mechanisms of action, potential therapeutic applications, and the latest advancements in its utilization.

The chemical structure of Porfiromycin is characterized by a porphyrin core, which is a cyclic tetrapyrrole pigment found in chlorophyll and heme groups. This core structure is essential for its interaction with various biological targets, particularly enzymes and proteins involved in critical metabolic pathways. The presence of specific functional groups on the porphyrin ring enhances its reactivity and binding affinity, making it a versatile candidate for drug development.

In recent years, Porfiromycin has been studied for its potential in combating resistant bacterial infections. Traditional antibiotics have faced challenges due to the rise of antibiotic-resistant strains, necessitating the discovery of novel therapeutic agents. The mechanism of action of Porfiromycin involves inhibiting bacterial enzymes that are crucial for their survival and proliferation. This has been highlighted in several studies where Porfiromycin demonstrated efficacy against multidrug-resistant bacteria, including those that are recalcitrant to conventional antibiotics.

Moreover, research has explored the application of Porfiromycin in cancer therapy. Its ability to selectively target and inhibit certain enzymes overexpressed in cancer cells has made it an attractive candidate for developing anticancer agents. Preclinical studies have shown promising results in reducing tumor growth and enhancing apoptosis in various cancer models. The specificity of Porfiromycin towards cancer cells while minimizing toxicity to healthy cells is a significant advantage, making it a promising candidate for further clinical investigation.

The synthesis and chemical modifications of Porfiromycin have also been extensively studied to optimize its pharmacological properties. Researchers have focused on modifying the porphyrin core and functional groups to enhance its solubility, bioavailability, and target specificity. These modifications have led to the development of novel derivatives with improved therapeutic profiles. For instance, some derivatives have shown enhanced efficacy in preclinical models while maintaining low systemic toxicity.

The role of Porfiromycin in regulating immune responses has also been an area of interest. Studies suggest that it can modulate immune cell function by interacting with various receptors and signaling pathways. This immunomodulatory activity could be exploited for treating autoimmune diseases and enhancing vaccine efficacy. The ability of Porfiromycin to modulate both innate and adaptive immune responses makes it a multifaceted compound with potential applications beyond infectious diseases and cancer.

In conclusion, Porfiromycin (CAS No. 801-52-5) is a compound with diverse applications in pharmaceuticals due to its unique chemical structure and biological properties. Recent research has highlighted its potential in combating resistant bacterial infections, cancer therapy, immune modulation, and other therapeutic areas. The ongoing studies on its synthesis, chemical modifications, and mechanisms of action continue to expand our understanding of this remarkable molecule. As research progresses, Porfiromycin is poised to play a significant role in the development of novel therapeutic strategies for various diseases.

801-52-5 (Porfiromycin) Related Products

Recommended suppliers
Shaanxi pure crystal photoelectric technology co. LTD
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Shaanxi pure crystal photoelectric technology co. LTD
SunaTech Inc.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
SunaTech Inc.
上海帛亦醫(yī)藥科技有限公司
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Shandong Feiyang Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Shandong Feiyang Chemical Co., Ltd
PRIBOLAB PTE.LTD
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
PRIBOLAB PTE.LTD