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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Oxolanes Oxolanes
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Oxolanes

Comprehensive Analysis of N-[(oxolan-2-yl)methyl]cyclopentanamine (CAS No. 797030-65-0): Properties, Applications, and Industry Insights

The compound N-[(oxolan-2-yl)methyl]cyclopentanamine (CAS No. 797030-65-0) is a specialized organic molecule that has garnered significant attention in pharmaceutical and chemical research. Its unique structural features, combining a cyclopentylamine moiety with a tetrahydrofuran (THF)-derived side chain, make it a versatile intermediate for synthetic applications. This article delves into its molecular characteristics, potential uses, and relevance in modern scientific advancements, addressing common queries such as "What is the synthesis route for N-[(oxolan-2-yl)methyl]cyclopentanamine?" and "How is CAS 797030-65-0 utilized in drug discovery?".

From a structural perspective, N-[(oxolan-2-yl)methyl]cyclopentanamine exhibits a balanced lipophilicity due to its cyclopentane ring and the polar oxolane (THF) group. This duality enhances its solubility profile, a critical factor in bioavailability—a hot topic in medicinal chemistry optimization. Researchers frequently search for "improving drug solubility using heterocyclic amines," and this compound serves as an exemplary case study. Its molecular weight of 169.25 g/mol and moderate polarity make it suitable for high-throughput screening in early-stage drug development.

In the context of green chemistry trends, 797030-65-0 has been explored as a building block for sustainable synthesis. The tetrahydrofuran component, derived from renewable resources like furfural, aligns with the industry's shift toward "bio-based chemical intermediates." Recent publications highlight its role in catalyzed reductive amination processes, reducing waste generation compared to traditional methods. This addresses frequently asked questions like "How to achieve atom economy in amine synthesis?"—a key concern for environmentally conscious manufacturers.

The pharmaceutical potential of N-[(oxolan-2-yl)methyl]cyclopentanamine extends to central nervous system (CNS) drug design. Its ability to cross the blood-brain barrier (BBB)—a recurring search term in neuropharmacology—has prompted investigations into its use as a scaffold for neurotransmitter analogs. Computational studies suggest favorable molecular docking with receptors associated with cognitive disorders, making it relevant to trending topics like "next-generation Alzheimer's disease therapeutics."

Analytical characterization of CAS 797030-65-0 typically involves advanced techniques such as LC-MS (Liquid Chromatography-Mass Spectrometry) and NMR spectroscopy, addressing quality control challenges often queried as "How to validate purity of complex amines?" The compound's proton NMR spectrum displays distinct peaks for the cyclopentyl (δ 1.5–2.1 ppm) and oxolanyl (δ 3.6–4.0 ppm) protons, serving as fingerprints for identification—a crucial aspect in Good Manufacturing Practice (GMP) compliance.

Industrial-scale production of N-[(oxolan-2-yl)methyl]cyclopentanamine often employs continuous flow chemistry, a trending search term in process optimization. This method enhances yield while minimizing byproducts, answering practical questions like "How to scale up amine production safely?" Patent literature reveals innovative routes using enzymatic catalysis, reflecting the growing demand for "biocatalysis in fine chemicals"—a subject with over 40% annual growth in scholarly searches.

Stability studies indicate that 797030-65-0 remains intact under standard storage conditions (2–8°C in inert atmosphere), a vital consideration for logistics professionals searching "amine compound shelf life." Its degradation products have been characterized via accelerated stability testing, with oxidation being the primary pathway—information crucial for formulating antioxidant-stabilized preparations.

Emerging applications include its use in metal-organic frameworks (MOFs), where its amine functionality coordinates with transition metals. This aligns with the booming interest in "MOFs for gas storage" and "catalytic nanomaterials," demonstrating the compound's interdisciplinary relevance. Recent studies have explored its derivatization into ionic liquids, addressing the popular query "Can amines form green solvents?"

From a regulatory standpoint, N-[(oxolan-2-yl)methyl]cyclopentanamine is not classified under restricted categories, making it accessible for global research—a point frequently clarified in regulatory forums. Its REACH compliance status and OECD test guidelines data are available, catering to queries about "EU chemical registration requirements."

In conclusion, CAS 797030-65-0 represents a compelling case study in modern chemical innovation. Its structural versatility answers pressing industry needs, from green synthesis to CNS drug development, while its analytical tractability satisfies quality assurance demands. As research progresses, this compound will likely feature in cutting-edge solutions for challenges articulated in search trends like "sustainable pharmacochemistry" and "precision molecular design."

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