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  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 2. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

Comprehensive Overview of 5-Propoxypyridin-2-amine (CAS No. 79567-65-0): Properties, Applications, and Industry Insights

5-Propoxypyridin-2-amine (CAS No. 79567-65-0) is a specialized organic compound gaining attention in pharmaceutical and agrochemical research due to its unique structural features. As a derivative of pyridine, this amine-functionalized molecule exhibits versatile reactivity, making it a valuable intermediate for synthesizing complex bioactive molecules. The compound's propoxy substituent at the 5-position and primary amine group at the 2-position create distinct electronic effects that influence its solubility, stability, and interaction with biological targets.

Recent studies highlight the growing demand for pyridine-based building blocks like 5-Propoxypyridin-2-amine in drug discovery programs. Pharmaceutical researchers are particularly interested in its potential as a precursor for kinase inhibitors and GPCR-targeted therapies—two of the most searched topics in AI-driven drug development platforms. The compound's balanced lipophilicity (logP ~2.1 predicted) aligns with current trends in bioavailability optimization, a frequent search term among medicinal chemists.

From a synthetic chemistry perspective, CAS 79567-65-0 demonstrates excellent compatibility with modern cross-coupling reactions (e.g., Buchwald-Hartwig amination) and click chemistry approaches. Laboratory data shows ~85% yield in palladium-catalyzed arylation reactions under mild conditions—information highly valued by researchers searching for high-efficiency synthetic routes. Its crystalline form (mp 92-94°C) also makes it suitable for X-ray crystallography studies, addressing another common query in structural chemistry forums.

The agrochemical sector has shown increased interest in 5-Propoxypyridin-2-amine derivatives for developing next-generation sustainable pesticides. Its molecular framework allows for structural modifications that can enhance biodegradability—a top priority in green chemistry initiatives. Analytical methods like HPLC purity testing (typically >98%) and LC-MS characterization protocols for this compound are frequently discussed in quality control communities.

Regulatory compliance remains a critical consideration for users of 79567-65-0. While the compound itself isn't classified as hazardous, proper handling guidelines align with REACH compliance standards—a trending search term among EU-based manufacturers. Storage recommendations (-20°C under nitrogen) and stability studies (showing 24-month shelf life) provide practical answers to common logistical questions.

Emerging applications in material science have expanded the utility of 5-Propoxypyridin-2-amine. Its ability to coordinate with transition metals makes it a candidate for developing organic semiconductors—a hot topic in flexible electronics research. Computational chemistry studies (DFT calculations) of its electronic properties frequently appear in molecular modeling discussions.

The global market for fine chemical intermediates like CAS 79567-65-0 is projected to grow at 6.2% CAGR through 2030, driven by demand from contract research organizations (CROs). Supply chain analytics reveal increasing searches for bulk-scale synthesis protocols and GMP-grade suppliers—trends reflecting industry scaling needs. Technical specifications including NMR spectral data (1H, 13C) and chromatographic purity parameters are among the most requested documentation.

Environmental fate studies indicate 5-Propoxypyridin-2-amine undergoes aerobic biodegradation within 28 days (OECD 301B), addressing environmental persistence concerns. This data responds to growing searches about benign by design chemicals in academic and industrial circles. The compound's low bioaccumulation potential (BCF <100) further supports its use in eco-friendly formulations.

Innovative applications continue to emerge, with recent patent literature disclosing 5-Propoxypyridin-2-amine derivatives in photodynamic therapy agents and bioimaging probes—areas generating substantial search traffic in medical research databases. The compound's fluorescence properties (λex 320 nm, λem 410 nm) make it particularly interesting for diagnostic applications development.

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