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Comprehensive Guide to 1-(4-Chloro-3-fluorophenyl)ethanamine (CAS No. 787633-87-8): Properties, Applications, and Market Insights

1-(4-Chloro-3-fluorophenyl)ethanamine (CAS No. 787633-87-8) is a specialized organic compound with significant relevance in pharmaceutical and chemical research. This amine derivative features a chloro-fluoro substituted phenyl ring, making it a valuable intermediate in the synthesis of bioactive molecules. Its molecular formula is C₈H₉ClFN, and it exhibits unique physicochemical properties that cater to diverse industrial applications.

The growing interest in fluorinated compounds and chlorinated aromatic amines has positioned 1-(4-Chloro-3-fluorophenyl)ethanamine as a compound of high demand. Researchers and manufacturers frequently search for "CAS 787633-87-8 suppliers" or "1-(4-Chloro-3-fluorophenyl)ethanamine synthesis," reflecting its commercial and scientific importance. This guide delves into its properties, applications, and the latest market trends to address these queries comprehensively.

Physicochemical Properties: 1-(4-Chloro-3-fluorophenyl)ethanamine is a light yellow to colorless liquid at room temperature, with a molecular weight of 173.61 g/mol. Its boiling point and solubility parameters make it suitable for reactions in polar organic solvents. The presence of both chloro and fluoro substituents enhances its reactivity, particularly in cross-coupling reactions and amide bond formations, which are pivotal in drug discovery.

Applications in Pharmaceuticals: One of the primary uses of 1-(4-Chloro-3-fluorophenyl)ethanamine is as a building block for active pharmaceutical ingredients (APIs). It serves as a key intermediate in the synthesis of central nervous system (CNS) drugs and antidepressants, owing to its ability to modulate neurotransmitter activity. Recent studies highlight its role in developing next-generation kinase inhibitors, a hot topic in oncology research.

Industrial and Research Significance: Beyond pharmaceuticals, this compound is utilized in agrochemical research for designing novel pesticides and herbicides. Its structural motif is also explored in material science, particularly for creating advanced polymers with enhanced thermal stability. Searches like "787633-87-8 applications" or "fluorophenyl ethanamine uses" underscore its multidisciplinary relevance.

Market Trends and Availability: The global demand for 1-(4-Chloro-3-fluorophenyl)ethanamine is rising, driven by advancements in precision medicine and green chemistry. Suppliers often list it under "high-purity amine intermediates," catering to labs and manufacturers. Regulatory compliance, such as REACH and GMP standards, ensures its safe handling and distribution, addressing common concerns about "CAS 787633-87-8 safety data."

Synthetic Routes and Innovations: Recent patents describe improved methods for synthesizing 1-(4-Chloro-3-fluorophenyl)ethanamine via catalytic hydrogenation or reductive amination, reducing environmental impact. These innovations align with the industry's shift toward sustainable chemistry, a trending topic among researchers searching for "eco-friendly amine synthesis."

Quality Control and Analytical Methods: Ensuring the purity of 787633-87-8 is critical for its applications. Techniques like HPLC, GC-MS, and NMR spectroscopy are commonly employed for quality assessment. Analytical data, often sought under "1-(4-Chloro-3-fluorophenyl)ethanamine characterization," confirms its structural integrity and suitability for high-end applications.

Future Prospects: With the expanding scope of fluorinated pharmaceuticals and smart materials, 1-(4-Chloro-3-fluorophenyl)ethanamine is poised to play a pivotal role. Emerging trends like "AI-driven drug discovery" and "bioisosteric replacements" further highlight its potential, making it a compound to watch in the coming decade.

• 1012305-33-7((1R)-1-(3-chloro-4-fluorophenyl)ethan-1-amine)
• 1245808-01-8((1S)-1-(4-chloro-3-fluoro-phenyl)ethanamine;hydrochloride)
• 1253790-80-5((R)-1-(4-Chloro-3-fluorophenyl)ethanamine hydrochloride)
• 2413817-92-0((1S)-1-(3-chloro-4-fluorophenyl)ethan-1-amine)
• 1257106-65-2((R)-1-(3-Chloro-4-fluorophenyl)ethanamine hydrochloride)
• 2413817-93-1((s)-1-(3-Chloro-4-fluorophenyl)ethanamine hydrochloride)
• 1021239-38-2(1-(3-Chloro-4-fluorophenyl)ethan-1-amine)
• 1213690-66-4((S)-1-(4-Chloro-3-fluorophenyl)propan-1-amine)
• 1114559-11-3((1S)-1-(4-chloro-3-fluorophenyl)ethan-1-amine)
• 1114559-14-6((1R)-1-(4-chloro-3-fluorophenyl)ethan-1-amine)