Cas no 78603-23-3 (Z-D-Lys(boc)-osu)

Z-D-Lys(boc)-osu is an N-hydroxysuccinimide (NHS) ester derivative of Boc-protected D-lysine, widely used in peptide synthesis and bioconjugation. Its key advantages include high reactivity with primary amines, enabling efficient amide bond formation under mild conditions. The Boc (tert-butoxycarbonyl) group provides orthogonal protection for the ε-amine of lysine, allowing selective deprotection in multi-step syntheses. The D-configuration offers stability against enzymatic degradation, making it valuable for designing protease-resistant peptides or chiral modifications. This compound is particularly useful in solid-phase peptide synthesis (SPPS) and crosslinking applications, ensuring controlled incorporation of lysine residues. Its crystalline form enhances handling precision, while the NHS ester moiety ensures consistent acylation kinetics.
Z-D-Lys(boc)-osu structure
Z-D-Lys(boc)-osu structure
Product Name:Z-D-Lys(boc)-osu
CAS No:78603-23-3
MF:C23H31N3O8
MW:477.507546663284
MDL:MFCD00237352
CID:553375
PubChem ID:56777339
Update Time:2025-11-02

Z-D-Lys(boc)-osu Chemical and Physical Properties

Names and Identifiers

    • Carbamic acid,[5-[[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(2,5-dioxo-1-pyrrolidinyl)carbonyl]oxy]pentyl]-,phenylmethyl ester, (R)- (9CI)
    • Carbamic acid,[5-[[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(2,5-dioxo-1-pyrrolidinyl)carbonyl]oxy]pentyl]-,phenylmethyl ester
    • N6-Boc-N2-Z-L-lysine N-succinimidyl ester
    • Nα-Z-Nε-Boc-D-lysine N-hydroxysuccinimide ester
    • Z-D-Lys(Boc)-OSu
    • NALPHA-Z-NEPSILON-BOC-D-LYSINE N-HYDROXYSUCCINIMIDE ESTER
    • AS-46964
    • CS-0364976
    • MFCD00237352
    • (2,5-dioxopyrrolidin-1-yl) (2R)-6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoate
    • 78603-23-3
    • NCFVVSXVXQRYFS-QGZVFWFLSA-N
    • F11047
    • Z-N-Epsilon-Boc-D-lysine N-hydroxysuccinimide ester
    • (R)-2,5-dioxopyrrolidin-1-yl 2-(benzyloxycarbonylamino)-6-(tert-butoxycarbonylamino)hexanoate
    • AKOS025289408
    • NA-Z-NE-BOC-D-LYSINE N-HYDROXYSUCCINIMIDE ESTER
    • 2,5-Dioxopyrrolidin-1-yl N2-((benzyloxy)carbonyl)-N6-(tert-butoxycarbonyl)-D-lysinate
    • Z-D-Lys(boc)-osu
    • MDL： MFCD00237352
    • Inchi： 1S/C23H31N3O8/c1-23(2,3)33-21(30)24-14-8-7-11-17(20(29)34-26-18(27)12-13-19(26)28)25-22(31)32-15-16-9-5-4-6-10-16/h4-6,9-10,17H,7-8,11-15H2,1-3H3,(H,24,30)(H,25,31)/t17-/m1/s1
    • InChI Key： NCFVVSXVXQRYFS-QGZVFWFLSA-N
    • SMILES： O(C([C@@H](CCCCNC(=O)OC(C)(C)C)NC(=O)OCC1C=CC=CC=1)=O)N1C(CCC1=O)=O

Computed Properties

  • Exact Mass: 477.21100
  • Monoisotopic Mass: 477.211
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 9
  • Heavy Atom Count: 34
  • Rotatable Bond Count: 16
  • Complexity: 727
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 140A^2
  • XLogP3: 2.3

Experimental Properties

  • Density: 1.27±0.1 g/cm3 (20 oC 760 Torr),
  • Solubility: Almost insoluble (0.04 g/l) (25 o C),
  • PSA: 140.34000
  • LogP: 3.30330

Z-D-Lys(boc)-osu Security Information

  • Storage Condition：-15°C

Z-D-Lys(boc)-osu Pricemore >>

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Z-D-Lys(boc)-osu Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:78603-23-3)Z-D-Lys(boc)-osu
Order Number:A1176706
Stock Status:in Stock
Quantity:25g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 01:35
Price ($):410.0

Z-D-Lys(boc)-osu Related Literature

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Additional information on Z-D-Lys(boc)-osu

Z-D-Lys(boc)-osu (CAS No. 78603-23-3): A Comprehensive Guide to Its Properties and Applications

Z-D-Lys(boc)-osu (CAS No. 78603-23-3) is a specialized peptide derivative widely used in biochemical research and pharmaceutical development. This compound, known for its N-terminal protection and activated ester properties, plays a critical role in peptide synthesis and protein engineering. Its unique structure, featuring a Z-group (benzyloxycarbonyl) and a Boc (tert-butoxycarbonyl) protecting group, makes it highly valuable for controlled reactions in organic chemistry.

The Z-D-Lys(boc)-osu compound is particularly significant in the context of drug discovery and bioconjugation. Researchers frequently utilize it for site-specific modifications of peptides and proteins, enabling advancements in targeted therapies and diagnostic tools. With the growing interest in personalized medicine and biologics, the demand for high-quality peptide building blocks like Z-D-Lys(boc)-osu has surged.

One of the key advantages of Z-D-Lys(boc)-osu is its compatibility with solid-phase peptide synthesis (SPPS). This method, widely adopted in modern laboratories, allows for efficient and scalable production of complex peptides. The N-hydroxysuccinimide (OSu) ester group in Z-D-Lys(boc)-osu ensures high reactivity with amino groups, facilitating smooth coupling reactions under mild conditions. This feature is particularly beneficial for researchers working on antibody-drug conjugates (ADCs) and other biopharmaceuticals.

Recent trends in biotechnology highlight the importance of Z-D-Lys(boc)-osu in proteomics and structural biology. Scientists are increasingly exploring its potential for post-translational modification studies and enzyme substrate design. The compound’s stability and selectivity make it an ideal choice for chemical biology applications, where precision and reproducibility are paramount.

From a commercial perspective, Z-D-Lys(boc)-osu is available through reputable suppliers specializing in fine chemicals and research reagents. Quality control measures, such as HPLC purity analysis and mass spectrometry verification, ensure that the compound meets the stringent requirements of academic and industrial laboratories. As the field of peptide therapeutics continues to expand, Z-D-Lys(boc)-osu remains a cornerstone for innovative research.

In summary, Z-D-Lys(boc)-osu (CAS No. 78603-23-3) is a versatile and indispensable tool in peptide chemistry. Its applications span from basic research to clinical development, aligning with current advancements in biomedical science. For researchers seeking reliable and efficient peptide synthesis reagents, this compound offers unparalleled performance and flexibility.

78603-23-3 (Z-D-Lys(boc)-osu) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:78603-23-3)Z-D-Lys(boc)-osu
A1176706
Purity:99%
Quantity:25g
Price ($):410.0
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