Cas no 78454-17-8 (7-Epi 10-desacetyl paclitaxel)
7-Epi 10-desacetyl paclitaxel is a semi-synthetic derivative of paclitaxel, a well-known microtubule-stabilizing agent with significant antitumor activity. This compound retains the core taxane structure while exhibiting modified pharmacokinetic and pharmacodynamic properties due to the absence of the 10-acetyl group and epimerization at the C-7 position. These structural alterations may influence its binding affinity to microtubules and metabolic stability, potentially offering improved efficacy or reduced toxicity profiles compared to paclitaxel. It serves as a valuable intermediate in the synthesis of novel taxane-based therapeutics and is of interest in oncology research for exploring structure-activity relationships and developing next-generation chemotherapeutic agents.
7-Epi 10-desacetyl paclitaxel structure
Product Name:7-Epi 10-desacetyl paclitaxel
CAS No:78454-17-8
MF:C45H49NO13
MW:811.869474172592
CID:573764
PubChem ID:14355298
Update Time:2025-05-28
7-Epi 10-desacetyl paclitaxel Chemical and Physical Properties
Names and Identifiers
-
- Paclitaxel Related Compound B
- 7-Epi-10-deacetyltaxol
- 7-Epi 10-Desacetyl Paclitaxel
- Ormosin VI
- 10-Deacetyl-7-epipaclitaxel
- benzenepr<wbr>
- LogP
- [ "" ]
- PF8TD9Q8G5
- 10-Deacetyl-7-epitaxol
- C45H49NO13
- 10-Deacetyl-7-epi-taxol
- 10-Desacetyl-7-epipaclitaxel
- 3390AH
- 7-Epi 10-desacetyl paclitaxel?
- Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)
- UNII-PF8TD9Q8G5
- MS-31505
- 78454-17-8
- CS-1143
- [(1S,2S,3R,4S,7R,9R,10S,12R,15S)-4-acetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
- HY-77572
- AC-34302
- AKOS037515411
- 10-O-Deacetyl-7-epi-paclitaxel
- DTXSID90559294
- CHEMBL500852
- (5beta,7alpha,10beta,13alpha)-4-(Acetyloxy)-13-{[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
- (1S,2S,3R,4S,7R,9R,10S,12R,15S)-4-(ACETYLOXY)-1,9,12-TRIHYDROXY-15-{[(2R,3S)-2-HYDROXY-3-PHENYL-3-(PHENYLFORMAMIDO)PROPANOYL]OXY}-10,14,17,17-TETRAMETHYL-11-OXO-6-OXATETRACYCLO[11.3.1.0(3),(1)?.0?,?]HEPTADEC-13-EN-2-YL BENZOATE
- A927989
- 2'-epi-3'-epi-10-Deacetyltaxol
- 7-EPI-10-DEACETYL-TAXOL
- PACLITAXEL IMPURITY H [EP IMPURITY]
- 4-(acetyloxy)-13alpha-[[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy]-1,7alpha,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
- 111149-94-1
- BENZENEPROPANOIC ACID, .BETA.-(BENZOYLAMINO)-.ALPHA.-HYDROXY-, (2AR,4R,4AS,6R,9S,11S,12S,12AR,12BS)-12B-(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,6,11-TRIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA(3,4)BENZ(1,2-B)OXET-9-YL ESTER, (.ALPHA.R,.BETA.S)-
- PD054526
- SMR000578100
- 10-Deacetyltaxol
- SMR000578101
- MLS001097661
- MLS001097671
- DA-60564
- 7-Epi 10-desacetyl paclitaxel
-
- Inchi： 1S/C45H49NO13/c1-24-29(57-41(54)35(50)33(26-15-9-6-10-16-26)46-39(52)27-17-11-7-12-18-27)22-45(55)38(58-40(53)28-19-13-8-14-20-28)36-43(5,37(51)34(49)32(24)42(45,3)4)30(48)21-31-44(36,23-56-31)59-25(2)47/h6-20,29-31,33-36,38,48-50,55H,21-23H2,1-5H3,(H,46,52)/t29-,30+,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1
- InChI Key： TYLVGQKNNUHXIP-DIYBZAJCSA-N
- SMILES： O1C[C@@]2([C@H]1C[C@H]([C@@]1(C)C([C@@H](C3=C(C)[C@H](C[C@](C3(C)C)([C@H]([C@H]21)OC(C1C=CC=CC=1)=O)O)OC([C@@H]([C@H](C1C=CC=CC=1)NC(C1C=CC=CC=1)=O)O)=O)O)=O)O)OC(C)=O
Computed Properties
- Exact Mass: 811.32039062 g/mol
- Monoisotopic Mass: 811.32039062 g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 5
- Hydrogen Bond Acceptor Count: 13
- Heavy Atom Count: 59
- Rotatable Bond Count: 12
- Complexity: 1680
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 11
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Molecular Weight: 811.9
- XLogP3: 1.9
- Topological Polar Surface Area: 215
Experimental Properties
- Color/Form: Powder
- Density: 1.4±0.1 g/cm3
- Melting Point: 163-170?C
- Boiling Point: 959.5℃/760mmHg
- Flash Point: 534.1±34.3 °C
- Vapor Pressure: 0.0±0.3 mmHg at 25°C
7-Epi 10-desacetyl paclitaxel Security Information
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Safety Instruction： H303+H313+H333
- Storage Condition：Store at 4 ℃, better at -4 ℃
7-Epi 10-desacetyl paclitaxel Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| MedChemExpress | HY-77572-2mg |
7-Epi 10-desacetyl paclitaxel |
78454-17-8 | 99.76% | 2mg |
￥660 | 2025-04-16 | |
| DC Chemicals | DC10855-100 mg |
7-Epi 10-Desacetyl Paclitaxel |
78454-17-8 | >98% | 100mg |
$550.0 | 2022-03-01 | |
| DC Chemicals | DC10855-250 mg |
7-Epi 10-Desacetyl Paclitaxel |
78454-17-8 | >98% | 250mg |
$800.0 | 2022-03-01 | |
| DC Chemicals | DC10855-1 g |
7-Epi 10-Desacetyl Paclitaxel |
78454-17-8 | >98% | 1g |
$1600.0 | 2022-03-01 | |
| TRC | E583500-1mg |
7-Epi 10-Desacetyl Paclitaxel |
78454-17-8 | 1mg |
$127.00 | 2023-05-18 | ||
| TRC | E583500-2.5mg |
7-Epi 10-Desacetyl Paclitaxel |
78454-17-8 | 2.5mg |
$ 181.00 | 2023-09-07 | ||
| TRC | E583500-5mg |
7-Epi 10-Desacetyl Paclitaxel |
78454-17-8 | 5mg |
$356.00 | 2023-05-18 | ||
| TRC | E583500-10mg |
7-Epi 10-Desacetyl Paclitaxel |
78454-17-8 | 10mg |
$ 678.00 | 2023-09-07 | ||
| TRC | E583500-25mg |
7-Epi 10-Desacetyl Paclitaxel |
78454-17-8 | 25mg |
$ 1231.00 | 2023-09-07 | ||
| Chengdu Biopurify Phytochemicals Ltd | SBP03777-20mg |
10-Deacetyl-7-epipaclitaxel |
78454-17-8 | 98% | 20mg |
$85 | 2023-09-20 |
7-Epi 10-desacetyl paclitaxel Suppliers
Amadis Chemical Company Limited
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Audited Supplier
(CAS:78454-17-8)7-Epi 10-desacetyl paclitaxel
Order Number:A927989
Stock Status:in Stock
Quantity:2mg/5mg/10mg
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 14:53
Price ($):150.0/313.0/501.0
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Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
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(CAS:78454-17-8)7-表-10-去乙?；颇献仙紝嶢
Order Number:LE25874603
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:50
Price ($):discuss personally
Email:[email protected]
7-Epi 10-desacetyl paclitaxel Related Literature
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J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
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Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
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Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
-
Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
Recommended suppliers
Amadis Chemical Company Limited
(CAS:78454-17-8)7-Epi 10-desacetyl paclitaxel
Purity:99%/99%/99%
Quantity:2mg/5mg/10mg
Price ($):150.0/313.0/501.0
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:78454-17-8)7-表-10-去乙?；颇献仙紝嶢
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry