Cas no 78242-21-4 (1-Propyl-1H-pyrazol-4-ol)

1-Propyl-1H-pyrazol-4-ol is a pyrazole derivative with a hydroxyl group at the 4-position and a propyl substituent at the 1-position. This compound serves as a versatile intermediate in organic synthesis, particularly in the development of pharmaceuticals, agrochemicals, and specialty chemicals. Its pyrazole core offers structural rigidity and hydrogen-bonding capability, enhancing its utility in designing biologically active molecules. The propyl group contributes to improved lipophilicity, influencing solubility and bioavailability in drug development. The hydroxyl group provides a reactive site for further functionalization, enabling diverse chemical modifications. This compound is valued for its stability and synthetic flexibility, making it a useful building block in medicinal and industrial chemistry research.
1-Propyl-1H-pyrazol-4-ol structure
1-Propyl-1H-pyrazol-4-ol structure
Product Name:1-Propyl-1H-pyrazol-4-ol
CAS No:78242-21-4
MF:C6H10N2O
MW:126.156401157379
MDL:MFCD22192551
CID:1030209
PubChem ID:13018410
Update Time:2025-10-28

1-Propyl-1H-pyrazol-4-ol Chemical and Physical Properties

Names and Identifiers

    • 1-Propyl-1H-pyrazol-4-ol
    • 1-Propylpyrazol-4-ol
    • TZMLEDRXPQCANG-UHFFFAOYSA-N
    • SCHEMBL16101449
    • 78242-21-4
    • A848992
    • MFCD22192551
    • BS-29543
    • AM90125
    • CS-0212066
    • F8885-6524
    • EN300-153893
    • AKOS016845839
    • DTXSID70515313
    • DB-201929
    • MDL: MFCD22192551
    • Inchi: 1S/C6H10N2O/c1-2-3-8-5-6(9)4-7-8/h4-5,9H,2-3H2,1H3
    • InChI Key: TZMLEDRXPQCANG-UHFFFAOYSA-N
    • SMILES: OC1C=NN(C=1)CCC

Computed Properties

  • Exact Mass: 126.079312947g/mol
  • Monoisotopic Mass: 126.079312947g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 9
  • Rotatable Bond Count: 2
  • Complexity: 87.1
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.7
  • Topological Polar Surface Area: 38?2

1-Propyl-1H-pyrazol-4-ol Pricemore >>

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Additional information on 1-Propyl-1H-pyrazol-4-ol

1-Propyl-1H-pyrazol-4-ol: A Comprehensive Overview

The compound 1-Propyl-1H-pyrazol-4-ol (CAS No. 78242-21-4) is a fascinating molecule with significant potential in various fields, including pharmaceuticals, agrochemicals, and materials science. This article delves into its structural properties, synthesis methods, biological activities, and recent advancements in its application.

1H-pyrazoles are a class of heterocyclic compounds known for their versatility and reactivity. The substitution of a propyl group at the 1-position of the pyrazole ring introduces unique electronic and steric properties to 1-Propyl-1H-pyrazol-4-ol. This makes it an attractive candidate for exploring novel chemical reactions and biological interactions.

Recent studies have highlighted the importance of pyrazole derivatives in drug discovery. For instance, researchers have reported that 1-Propyl-1H-pyrazol-4-ol exhibits potent antioxidant activity, which could be harnessed in the development of therapeutic agents for oxidative stress-related diseases. Additionally, its ability to act as a ligand in metalloenzyme inhibition has opened new avenues in anti-cancer drug design.

The synthesis of 1-Propyl-1H-pyrazol-4-ol involves a multi-step process that typically begins with the preparation of pyrazole intermediates. Recent advancements in catalytic methods have significantly improved the yield and purity of this compound. For example, the use of microwave-assisted synthesis has been shown to accelerate reaction rates while minimizing side reactions.

In terms of biological applications, 1H-pyrazoles like 1-propyl derivative have been explored for their anti-inflammatory and analgesic properties. Preclinical studies suggest that this compound could serve as a lead molecule for developing next-generation pain relievers with reduced side effects.

Moreover, the incorporation of propyl groups into pyrazole frameworks has been shown to enhance solubility and bioavailability. This is particularly important for drug delivery systems where efficient absorption is critical. Recent research has also focused on the use of 1-propyl derivative as a building block for constructing more complex molecular architectures.

The environmental impact of 1-propyl derivative is another area gaining attention. Studies indicate that it has low toxicity towards non-target organisms, making it suitable for agricultural applications such as pesticides or fungicides. However, further research is needed to fully understand its long-term ecological effects.

In conclusion, 1-propyl derivative (CAS No. 78242-21-4) stands out as a promising compound with diverse applications across multiple disciplines. Its unique chemical properties and potential biological activities make it a subject of continued interest among researchers worldwide.

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