• 1. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
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• 2. Excitation energies from ground-state density-functionals by means of generator coordinates
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• 3. Exciton manipulation in rippled transition metal dichalcogenides?
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• 4. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Phenylpyrazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles Phenylpyrazoles

Comprehensive Guide to 1-Phenyl-1H-Indazole (CAS No. 7788-69-4): Properties, Applications, and Industry Insights

1-Phenyl-1H-Indazole (CAS No. 7788-69-4) is a heterocyclic organic compound gaining significant attention in pharmaceutical and chemical research. This indazole derivative features a phenyl group attached to the nitrogen atom of the indazole ring, creating a unique molecular structure with diverse applications. Researchers and industry professionals frequently search for terms like "1-Phenyl-1H-Indazole synthesis," "7788-69-4 applications," and "indazole derivatives in drug discovery," reflecting its growing importance in modern chemistry.

The compound's molecular formula (C13H10N2) and weight (194.23 g/mol) make it a versatile building block in medicinal chemistry. Recent studies highlight its potential as a pharmacophore in designing kinase inhibitors and G-protein-coupled receptor (GPCR) modulators. With the pharmaceutical industry's increasing focus on targeted therapies, 1-Phenyl-1H-Indazole has emerged as a valuable scaffold for developing novel therapeutic agents. Its structure-activity relationship (SAR) properties are particularly interesting to researchers working on central nervous system (CNS) disorders and inflammatory conditions.

From a synthetic chemistry perspective, 7788-69-4 serves as an important intermediate in multi-step organic synthesis. The compound's crystalline form and moderate solubility in common organic solvents (DMSO, ethanol) make it practical for laboratory applications. Analytical chemists often investigate its HPLC purity and spectroscopic characteristics, including distinctive NMR peaks and mass spectrometry fragmentation patterns. These properties are crucial for quality control in research settings.

The thermal stability of 1-Phenyl-1H-Indazole (melting point 148-152°C) makes it suitable for various high-temperature reactions. Recent patent literature reveals innovative applications in material science, particularly in developing organic electronic materials and liquid crystal displays (LCDs). As the demand for advanced functional materials grows, this compound's role in creating charge-transport layers and electroluminescent compounds is becoming increasingly valuable.

In biochemical research, 1-Phenyl-1H-Indazole derivatives show promising enzyme inhibition properties. Computational chemistry studies using molecular docking simulations suggest potential interactions with various biological targets. This aligns with current trends in computer-aided drug design (CADD), where researchers frequently search for "indazole-based drug candidates" and "small molecule therapeutics." The compound's lipophilicity (LogP ~2.8) and hydrogen bonding capacity contribute to its bioavailability profile.

Quality standards for CAS 7788-69-4 typically require ≥98% purity, verified by chromatographic methods. The compound's stability under various storage conditions (recommended at 2-8°C) makes it practical for long-term research projects. Safety data indicates it should be handled with standard laboratory precautions, though it doesn't fall under hazardous material classifications. This aspect is particularly important for researchers searching for "safe heterocyclic compounds" and "non-toxic research chemicals."

Emerging applications include use as a fluorescence probe in biochemical assays and as a ligand in coordination chemistry. The compound's aromatic system allows for interesting π-π stacking interactions, relevant in supramolecular chemistry applications. These cutting-edge uses align with current scientific interests in nanotechnology and molecular recognition systems.

Market analysis shows growing demand for 1-Phenyl-1H-Indazole in both academic and industrial research. Suppliers often highlight its availability in various quantities (mg to kg scale) to meet different research needs. The compound's intellectual property landscape includes numerous patents covering synthetic methods and specific derivatives, reflecting its commercial potential in drug development pipelines.

Future research directions may explore its potential in combination therapies and precision medicine applications. The compound's modular structure allows for extensive structure modification, making it valuable for medicinal chemistry optimization projects. As the scientific community continues to investigate indazole pharmacology, 1-Phenyl-1H-Indazole (CAS No. 7788-69-4) remains a compound of significant interest with untapped potential.

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