• 1. Fe3O4/FeS2 heterostructures enable efficient oxygen evolution reaction?
  Xingqun Zheng,Lele Song,Xin Feng,Li Li,Zidong Wei J. Mater. Chem. A, 2020,8, 14145-14151
• 2. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 3. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 4. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 5. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734

Recent Advances in the Application of 5-Bromo-2-chloro-4-methylpyridine (CAS 778611-64-6) in Chemical Biology and Pharmaceutical Research

The compound 5-Bromo-2-chloro-4-methylpyridine (CAS 778611-64-6) has emerged as a critical intermediate in the synthesis of various biologically active molecules and pharmaceutical agents. Recent studies have highlighted its versatility in medicinal chemistry, particularly in the development of kinase inhibitors, antiviral agents, and other therapeutic compounds. This research brief synthesizes the latest findings on the applications, synthetic methodologies, and biological activities associated with this compound, providing a comprehensive overview for researchers in the field.

One of the most significant applications of 5-Bromo-2-chloro-4-methylpyridine is its role as a building block in the synthesis of kinase inhibitors. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility in the development of selective JAK2 inhibitors, which are promising candidates for treating myeloproliferative disorders. The bromo and chloro substituents on the pyridine ring allow for efficient functionalization via cross-coupling reactions, enabling the rapid assembly of diverse chemical libraries for high-throughput screening.

In the realm of antiviral research, 5-Bromo-2-chloro-4-methylpyridine has shown particular promise as a precursor for RNA-dependent RNA polymerase (RdRp) inhibitors. A recent patent application (WO2023051234) describes its incorporation into novel compounds targeting SARS-CoV-2 replication. The electron-withdrawing properties of the halogen substituents enhance the binding affinity of these molecules to the viral polymerase, while the methyl group improves metabolic stability.

From a synthetic chemistry perspective, several innovative approaches to modifying 5-Bromo-2-chloro-4-methylpyridine have been reported. A 2024 Nature Communications paper detailed a photoredox-catalyzed C-H functionalization protocol that enables direct modification of the pyridine core without requiring protection of the halogen groups. This methodology significantly streamlines the synthesis of complex derivatives and has been adopted by multiple pharmaceutical research groups.

The compound's biological activity profile has also been expanded in recent investigations. Screening studies published in Bioorganic & Medicinal Chemistry Letters (2023) identified several 5-Bromo-2-chloro-4-methylpyridine derivatives with potent activity against protein arginine methyltransferase 5 (PRMT5), an emerging cancer target. The unique electronic properties imparted by the substitution pattern appear to be crucial for achieving both potency and selectivity in this enzyme class.

Looking forward, the demand for 5-Bromo-2-chloro-4-methylpyridine is expected to grow as its applications in drug discovery continue to expand. Current research efforts are focusing on developing more sustainable synthetic routes to this intermediate and exploring its potential in new therapeutic areas such as neurodegenerative diseases and autoimmune disorders. The compound's versatility and the growing body of research supporting its utility suggest it will remain a valuable tool in medicinal chemistry for years to come.

• 1060802-23-4(5-Bromo-2-chloropyridine-4-carbaldehyde)
• 918145-29-6(3-Bromo-6-chloro-2,4-dimethylpyridine)
• 1211515-17-1(5-bromo-2-chloropyridine-4-carbonitrile)
• 1000017-92-4(2-Chloro-3,5-dibromo-4-methylpyridine)
• 778611-65-7(5-Bromo-4-(bromomethyl)-2-chloropyridine)
• 1227509-46-7(Pyridine, 3-bromo-4-(bromomethyl)-2-chloro-)
• 1227402-54-1(5,5'-dibromo-2,2'-dichloro-[4,4']bipyridinyl)
• 1227402-55-2(5-bromo-2,2'-dichloro-[4,4']bipyridinyl)
• 55404-31-4(3-bromo-2-chloro-4-methylpyridine)
• 1211531-97-3((5-Bromo-2-chloropyridin-4-yl)methanol)