• 1. Emerging enantiomeric resolution materials with homochiral nano-fabrications
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• 2. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 3. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Anisoles

1-Fluoro-4-iodo-2-methoxybenzene (CAS No. 773855-64-4): A Versatile Fluorinated Aromatic Compound

1-Fluoro-4-iodo-2-methoxybenzene (CAS No. 773855-64-4) is an important fluorinated aromatic compound that has gained significant attention in pharmaceutical and material science research. This halogen-substituted benzene derivative combines three distinct functional groups - fluorine, iodine, and methoxy - making it a valuable building block for various synthetic applications. The compound's molecular formula is C₇H₆FIO, with a molecular weight of 252.02 g/mol.

The unique electronic properties of 1-fluoro-4-iodo-2-methoxybenzene stem from its strategic substitution pattern. The fluorine atom at position 1 provides strong electron-withdrawing characteristics, while the methoxy group at position 2 offers electron-donating properties. This push-pull electronic configuration makes the compound particularly interesting for organic electronics applications, a rapidly growing field that aligns with current trends in sustainable energy and flexible electronics.

Recent studies highlight the compound's utility in cross-coupling reactions, especially in palladium-catalyzed transformations. The iodo substituent at position 4 serves as an excellent leaving group, enabling efficient formation of carbon-carbon bonds through reactions like Suzuki, Stille, or Sonogashira couplings. These properties make 1-fluoro-4-iodo-2-methoxybenzene 773855-64-4 particularly valuable for pharmaceutical intermediate synthesis, addressing the growing demand for novel drug discovery scaffolds.

In material science, researchers are exploring fluorinated aromatic compounds like 1-fluoro-4-iodo-2-methoxybenzene for developing advanced organic semiconductors. The compound's ability to modify electronic properties through its substituents makes it attractive for designing organic field-effect transistors (OFETs) and organic light-emitting diodes (OLEDs), technologies that are revolutionizing display and lighting industries.

The synthesis of 1-fluoro-4-iodo-2-methoxybenzene typically involves selective halogenation of 2-methoxyfluorobenzene precursors. Modern synthetic approaches emphasize green chemistry principles, reflecting the pharmaceutical industry's shift toward more sustainable practices. This aligns with current environmental concerns and the increasing regulatory pressure on chemical manufacturing processes.

Analytical characterization of CAS 773855-64-4 typically includes nuclear magnetic resonance (NMR) spectroscopy, with distinctive signals observed at δ 7.6-7.8 ppm (aromatic protons), δ 3.9 ppm (methoxy protons), and characteristic 19F NMR and 13C NMR patterns. Mass spectrometry confirms the molecular ion peak at m/z 252, with fragmentation patterns characteristic of iodo- and fluoro-substituted benzenes.

The stability of 1-fluoro-4-iodo-2-methoxybenzene under various conditions has been extensively studied. The compound demonstrates good thermal stability up to 150°C, making it suitable for many synthetic applications. However, like many iodoaromatic compounds, it should be protected from prolonged light exposure to prevent potential degradation.

In pharmaceutical applications, the fluoro and methoxy groups of 1-fluoro-4-iodo-2-methoxybenzene 773855-64-4 are particularly valuable. Fluorine incorporation often improves metabolic stability and membrane permeability of drug candidates, while the methoxy group can participate in hydrogen bonding interactions with biological targets. These features make the compound a popular choice for medicinal chemistry projects focused on CNS drugs and anticancer agents.

The global market for fluorinated building blocks like 1-fluoro-4-iodo-2-methoxybenzene is experiencing steady growth, driven by increasing demand from the pharmaceutical and electronics sectors. Market analysts project a compound annual growth rate (CAGR) of 6-8% for such specialty chemicals over the next five years, reflecting broader trends in personalized medicine and organic electronics.

Quality control standards for CAS No. 773855-64-4 typically specify purity levels ≥98% by HPLC, with strict limits on residual solvents and heavy metals. These specifications ensure the compound's suitability for sensitive applications in drug discovery and material science. Leading manufacturers employ advanced purification techniques like preparative HPLC and recrystallization to meet these rigorous standards.

Future research directions for 1-fluoro-4-iodo-2-methoxybenzene derivatives may explore their potential in metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), emerging areas in materials chemistry. The compound's ability to participate in various coupling reactions while maintaining structural integrity makes it an attractive candidate for designing novel porous materials with applications in gas storage and separation technologies.

Environmental and safety considerations for handling 1-fluoro-4-iodo-2-methoxybenzene follow standard laboratory protocols for halogenated aromatic compounds. While not classified as highly hazardous, appropriate personal protective equipment (PPE) including gloves and safety glasses should be used. Proper ventilation is recommended when handling the compound in powder form to minimize inhalation risks.

In conclusion, 1-Fluoro-4-iodo-2-methoxybenzene (CAS No. 773855-64-4) represents a versatile and valuable compound in modern chemical research and industrial applications. Its unique combination of substituents offers multiple handles for further functionalization, making it particularly useful for pharmaceutical intermediate synthesis and advanced material development. As research continues to uncover new applications for fluorinated aromatic building blocks, compounds like 1-fluoro-4-iodo-2-methoxybenzene will likely play increasingly important roles in scientific and technological advancements.

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