• 1. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 2. An approach to asymmetric synthesis of β-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement?
  Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
• 3. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 4. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 5. An atomic scale study of defects in Co2FeAl
  Ravi Kumar Yadav,R. Govindaraj Phys. Chem. Chem. Phys., 2020,22, 26876-26886

Research Brief on 3-Chloro-2-iodopyridine (CAS: 77332-89-9) in Chemical Biology and Pharmaceutical Applications

3-Chloro-2-iodopyridine (CAS: 77332-89-9) is a halogenated pyridine derivative that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound serves as a critical building block in the synthesis of various bioactive molecules, including kinase inhibitors, antimicrobial agents, and other therapeutic candidates. Its unique structural features, characterized by the presence of both chlorine and iodine substituents, make it a valuable intermediate in cross-coupling reactions and other synthetic transformations.

Recent studies have highlighted the role of 3-Chloro-2-iodopyridine in the development of novel drug candidates. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility in the synthesis of potent PI3K inhibitors, which are being investigated for their potential in cancer therapy. The compound's reactivity allows for selective functionalization, enabling researchers to explore diverse chemical spaces and optimize drug-like properties. Additionally, its stability under various reaction conditions makes it a preferred choice for high-throughput screening and combinatorial chemistry approaches.

In the context of chemical biology, 3-Chloro-2-iodopyridine has been employed as a key intermediate in the design of molecular probes and imaging agents. A recent publication in ACS Chemical Biology (2024) detailed its use in the development of fluorescent probes for detecting reactive oxygen species (ROS) in cellular systems. The iodine moiety in the compound facilitates radiolabeling, making it suitable for positron emission tomography (PET) imaging applications. This dual functionality underscores its potential in both diagnostic and therapeutic modalities.

The synthetic methodologies involving 3-Chloro-2-iodopyridine have also seen advancements. A 2023 report in Organic Letters described a novel palladium-catalyzed cross-coupling reaction that leverages the compound's halogenated sites to achieve high yields and selectivity. Such innovations are critical for scaling up production and ensuring the availability of this intermediate for large-scale pharmaceutical manufacturing. Furthermore, computational studies have provided insights into the compound's reactivity patterns, aiding in the rational design of more efficient synthetic routes.

Despite its promising applications, challenges remain in the handling and storage of 3-Chloro-2-iodopyridine due to its sensitivity to light and moisture. Recent research has focused on developing stabilized formulations and protective packaging to mitigate these issues. Additionally, regulatory considerations regarding its use in drug development are being addressed, with ongoing studies evaluating its toxicity profile and environmental impact.

In conclusion, 3-Chloro-2-iodopyridine (CAS: 77332-89-9) continues to be a pivotal compound in chemical biology and pharmaceutical research. Its multifaceted applications, from drug synthesis to molecular imaging, highlight its importance in advancing scientific and medical frontiers. Future research is expected to further explore its potential, particularly in the context of personalized medicine and targeted therapies.

• 26856-63-3(Pyridine,trichloroiodo- (7CI,8CI,9CI))
• 1188435-00-8(3-Chloro-2,4-diiodopyridine)
• 1214382-84-9(3-Chloro-2-iodo-6-methylpyridine)
• 1196152-86-9(4,5-Dichloro-2-iodopyridine)
• 1353056-41-3(3,6-chloro-2-iodopyridine)
• 244221-57-6(5-chloro-2-iodo-pyridine)
• 1214350-54-5(3,5-Dichloro-2-iodopyridine)
• 1478090-75-3(3-Chloro-2,6-diiodopyridine)
• 514798-11-9(Pyridine, 3-chloro-5-fluoro-2-iodo-)
• 925890-54-6(4-Chloro-1-iodoisoquinoline)