• 1. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
• 2. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 3. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 4. An investigation into the origin of variations in photovoltaic performance using D–D–π–A and D–A–π–A triphenylimidazole dyes with a copper electrolyte?
  Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789
• 5. Alumina coating on 5 V lithium cobalt fluorophosphate cathode material for lithium secondary batteries – synthesis and electrochemical properties?
  S. Amaresh,K. Karthikeyan,K. J. Kim,Y. S. Lee RSC Adv., 2014,4, 23107-23115

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Comprehensive Guide to Boc-L-2-aminoadipic Acid (CAS No. 77302-72-8): Properties, Applications, and Industry Insights

Boc-L-2-aminoadipic Acid (CAS No. 77302-72-8) is a specialized protected amino acid derivative widely utilized in peptide synthesis, pharmaceutical research, and biochemical studies. This compound features a tert-butoxycarbonyl (Boc) protecting group, which enhances its stability during chemical reactions. With the growing demand for custom peptide synthesis and drug discovery, this molecule has gained significant attention in both academic and industrial settings.

The unique structure of Boc-L-2-aminoadipic Acid makes it invaluable for constructing complex peptides with non-natural amino acids. Researchers frequently employ it to study enzyme-substrate interactions or design bioactive compounds. Its CAS No. 77302-72-8 serves as a critical identifier for procurement and regulatory compliance, ensuring precise material tracking in GMP-grade manufacturing.

Recent trends highlight its role in next-generation therapeutics, particularly in targeted drug delivery systems. As the pharmaceutical industry shifts toward personalized medicine, compounds like Boc-L-2-aminoadipic Acid enable the development of peptide-based drugs with improved specificity. This aligns with frequent search queries such as "Boc-protected amino acids for peptide synthesis" or "CAS 77302-72-8 applications", reflecting user interest in its practical uses.

From a technical perspective, the Boc group in Boc-L-2-aminoadipic Acid offers acid-labile protection, allowing selective deprotection under mild conditions—a feature highly valued in solid-phase peptide synthesis (SPPS). This property answers common questions like "How to remove Boc protecting group?" often searched by synthetic chemists. Additionally, its compatibility with Fmoc chemistry expands its utility in hybrid protection strategies.

Quality control is paramount for CAS No. 77302-72-8, with analytical techniques like HPLC and mass spectrometry ensuring purity >98%. Such specifications cater to laboratories requiring high-purity building blocks for cGMP applications. The compound’s shelf stability and solubility profiles (soluble in DMSO/DMF) further address practical concerns voiced in forums discussing "storage conditions for Boc-amino acids".

Emerging applications include its use in bioconjugation for antibody-drug conjugates (ADCs) and proteomics research. These cutting-edge uses respond to trending searches on "amino acid linkers in ADC development", positioning Boc-L-2-aminoadipic Acid as a versatile tool in biopharmaceutical innovation. Its adipic acid backbone also enables novel polymeric material design, bridging peptide chemistry with biomaterials engineering.

For procurement specialists, understanding supplier qualifications for CAS No. 77302-72-8 is crucial. Reputable vendors provide detailed COAs and stability data, addressing FAQs like "Boc-L-2-aminoadipic Acid suppliers with ISO certification". The compound’s pricing often correlates with batch purity and scalability—key factors in cost-sensitive R&D environments.

Environmental and safety considerations for Boc-L-2-aminoadipic Acid follow standard laboratory safety protocols. While not classified as hazardous, proper handling with PPE and ventilation aligns with institutional EH&S guidelines—an aspect frequently queried as "Boc amino acid SDS sheet requirements". Such practical information enhances workplace safety in research facilities.

In conclusion, Boc-L-2-aminoadipic Acid (CAS No. 77302-72-8) represents a critical reagent at the intersection of peptide science and medicinal chemistry. Its evolving applications mirror industry shifts toward precision therapeutics and sustainable biomaterials, making it a compound of enduring relevance in life sciences.

• 2419-94-5(N-Boc-L-glutamic acid)
• 13139-16-7(Boc-L-Ile-OH)
• 13139-15-6(Boc-L-Leu-OH)
• 13726-84-6(Boc-Glu(OtBu)-OH)
• 13726-85-7(tert-Butoxycarbonyl-L-glutamine)
• 24277-39-2(Boc-Glu-OtBu)
• 13726-67-5(Boc-Asp-OH)
• 13734-28-6(Boc-Lys-OH)
• 2418-95-3((S)-2-Amino-6-((tert-butoxycarbonyl)amino)hexanoic acid)
• 13734-41-3(Boc-L-Valine)