• 1. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 2. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 3. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 4. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 5. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Aralkylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Aralkylamines

Compound CAS No 771581-15-8: (3-Chloropyrazin-2-yl)methanamine

The compound with CAS No 771581-15-8, commonly referred to as (3-Chloropyrazin-2-yl)methanamine, is a fascinating molecule with significant applications in various fields of chemistry and materials science. This compound is characterized by its unique structure, which includes a pyrazine ring substituted with a chlorine atom at the 3-position and an amino group attached via a methylene bridge at the 2-position. The pyrazine ring, a six-membered aromatic structure with two nitrogen atoms, forms the core of this molecule, contributing to its electronic properties and reactivity.

Recent studies have highlighted the importance of (3-Chloropyrazin-2-yl)methanamine in the development of advanced materials, particularly in the field of coordination chemistry. Researchers have explored its ability to act as a ligand in metal complexes, where the amino group serves as a coordinating site. This property has led to the synthesis of novel metalloporphyrins and metallophthalocyanines, which are widely used in catalysis, sensing, and optoelectronic devices. The presence of the chlorine substituent further enhances the electronic versatility of the molecule, making it a valuable building block in supramolecular chemistry.

In addition to its role in materials science, (3-Chloropyrazin-2-yl)methanamine has shown promise in medicinal chemistry. Its ability to form hydrogen bonds and its aromaticity make it an attractive candidate for drug design. Recent research has focused on its potential as an inhibitor of certain enzymes involved in neurodegenerative diseases. For instance, studies have demonstrated that derivatives of this compound can modulate the activity of histone deacetylases (HDACs), which are implicated in Alzheimer's disease and other neurological disorders.

The synthesis of (3-Chloropyrazin-2-yl)methanamine typically involves multi-step organic reactions. A common approach starts with the preparation of pyrazine derivatives through cyclization reactions, followed by substitution at specific positions. The introduction of the chlorine atom and the amino group requires precise control over reaction conditions to ensure high yields and purity. Advanced techniques such as microwave-assisted synthesis and catalytic methods have been employed to optimize this process, making it more efficient and scalable for industrial applications.

From an environmental perspective, (3-Chloropyrazin-2-yl)methanamine has been studied for its biodegradability and toxicity profiles. Initial assessments suggest that it is not highly toxic to aquatic organisms under standard conditions, but further research is needed to fully understand its environmental impact. Regulatory agencies are closely monitoring its use in industrial settings to ensure compliance with safety standards.

In conclusion, (3-Chloropyrazin-2-yl)methanamine is a versatile compound with diverse applications across multiple disciplines. Its unique chemical structure and functional groups make it an invaluable tool in modern chemistry. As research continues to uncover new properties and uses for this compound, it is likely to play an increasingly important role in both academic and industrial settings.

• 867165-53-5((3-Chloropyrazin-2-yl)methanamine dihydrochloride)
• 1060814-53-0((5-Chloropyrazin-2-YL)methanamine)
• 95-58-9(2-Chloro-3-methylpyrazine)
• 1289386-39-5((3-Chloropyrazin-2-ylmethyl)ethylamine)
• 939412-86-9((3-chloropyrazin-2-yl)methanamine;hydrochloride)
• 95-89-6(3-Chloro-2,5-dimethylpyrazine)
• 1060814-52-9((6-Chloropyrazin-2-yl)methanamine)
• 1289385-16-5((3-CHLORO-PYRAZIN-2-YLMETHYL)-ISOPROPYL-AMINE)
• 53238-80-5(S 4001)
• 1357945-24-4((6-Chloropyrazin-2-yl)methanamine hydrochloride)