Cas no 769920-90-3 ({2-4-(trifluoromethyl)phenyl-1,3-thiazol-4-yl}methanamine)

{2-[4-(Trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine is a fluorinated thiazole derivative characterized by its trifluoromethylphenyl substituent, which enhances its lipophilicity and metabolic stability. The compound’s structure features a reactive primary amine group, making it a versatile intermediate for pharmaceutical and agrochemical applications. Its electron-withdrawing trifluoromethyl group contributes to improved binding affinity in target interactions, particularly in medicinal chemistry for enzyme or receptor modulation. The thiazole core further offers structural rigidity, promoting selectivity in biological systems. This compound is valuable in the synthesis of bioactive molecules, particularly in the development of kinase inhibitors or antimicrobial agents, due to its balanced physicochemical properties and synthetic adaptability.
{2-4-(trifluoromethyl)phenyl-1,3-thiazol-4-yl}methanamine structure
769920-90-3 structure
Product Name:{2-4-(trifluoromethyl)phenyl-1,3-thiazol-4-yl}methanamine
CAS No:769920-90-3
MF:C11H9F3N2S
MW:258.262771368027
MDL:MFCD06797507
CID:551268
PubChem ID:2794765
Update Time:2025-06-07

{2-4-(trifluoromethyl)phenyl-1,3-thiazol-4-yl}methanamine Chemical and Physical Properties

Names and Identifiers

    • 4-Thiazolemethanamine,2-[4-(trifluoromethyl)phenyl]-
    • [2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl]methanamine
    • [2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL]METHYLAMINE
    • {2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
    • {2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-4-YL}METHYLAMINE
    • {2-4-(trifluoromethyl)phenyl-1,3-thiazol-4-yl}methanamine
    • MFCD06797507
    • CS-0264955
    • DTXSID10383391
    • 1-{2-[4-(Trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
    • Z802601450
    • EN300-95512
    • 769920-90-3
    • SCHEMBL7895624
    • AKOS009124333
    • CNEYBCFNATWSJU-UHFFFAOYSA-N
    • MDL： MFCD06797507
    • Inchi： 1S/C11H9F3N2S/c12-11(13,14)8-3-1-7(2-4-8)10-16-9(5-15)6-17-10/h1-4,6H,5,15H2
    • InChI Key： CNEYBCFNATWSJU-UHFFFAOYSA-N
    • SMILES： S1C=C(CN)N=C1C1C=CC(C(F)(F)F)=CC=1

Computed Properties

  • Exact Mass: 258.04400
  • Monoisotopic Mass: 258.04385396g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 17
  • Rotatable Bond Count: 2
  • Complexity: 252
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.4
  • Topological Polar Surface Area: 67.2?2

Experimental Properties

  • Density: 1.352
  • Melting Point: 52 °C
  • Boiling Point: 348.5°C at 760 mmHg
  • Flash Point: 164.6°C
  • Refractive Index: 1.549
  • PSA: 67.15000
  • LogP: 3.98790

{2-4-(trifluoromethyl)phenyl-1,3-thiazol-4-yl}methanamine Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
Enamine
EN300-95512-0.05g
{2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
 769920-90-3 87%
0.05g
 $86.0 2024-05-21
Enamine
EN300-95512-0.1g
{2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
 769920-90-3 87%
0.1g
 $129.0 2024-05-21
Enamine
EN300-95512-0.25g
{2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
 769920-90-3 87%
0.25g
 $183.0 2024-05-21
Enamine
EN300-95512-0.5g
{2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
 769920-90-3 87%
0.5g
 $342.0 2024-05-21
Enamine
EN300-95512-1.0g
{2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
 769920-90-3 87%
1.0g
 $457.0 2024-05-21
Enamine
EN300-95512-2.5g
{2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
 769920-90-3 87%
2.5g
 $894.0 2024-05-21
Enamine
EN300-95512-5.0g
{2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
 769920-90-3 87%
5.0g
 $1322.0 2024-05-21
Enamine
EN300-95512-10.0g
{2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
 769920-90-3 87%
10.0g
 $1962.0 2024-05-21
Enamine
EN300-95512-1g
{2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
 769920-90-3 94%
1g
 $457.0 2023-09-01
Enamine
EN300-95512-5g
{2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-4-yl}methanamine
 769920-90-3 94%
5g
 $1322.0 2023-09-01

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