• 1. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 2. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 3. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 4. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 5. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Halobenzoic acids and derivatives

3-Bromo-4-Methylbenzoic Acid: A Comprehensive Overview

3-Bromo-4-methylbenzoic acid, also known by its CAS number 7697-26-9, is a versatile organic compound with significant applications in various fields of chemistry and material science. This compound, characterized by its bromine and methyl substituents on the benzoic acid backbone, has garnered attention due to its unique chemical properties and potential for functionalization in advanced materials and pharmaceuticals.

The structure of 3-bromo-4-methylbenzoic acid consists of a benzene ring with a bromine atom at the 3-position and a methyl group at the 4-position, along with a carboxylic acid group at the para position. This substitution pattern imparts distinct electronic and steric effects, making it an ideal candidate for further chemical modifications. Recent studies have explored the use of this compound as a building block in the synthesis of bioactive molecules, where its reactivity and selectivity play crucial roles.

In terms of physical properties, 3-bromo-4-methylbenzoic acid exhibits a melting point of approximately 150°C and is sparingly soluble in water but readily soluble in organic solvents such as dichloromethane and ethyl acetate. These properties make it suitable for various synthetic procedures, including nucleophilic aromatic substitution and coupling reactions. Researchers have utilized these characteristics to develop novel materials with tailored functionalities, such as fluorescent sensors and drug delivery systems.

The synthesis of 3-bromo-4-methylbenzoic acid typically involves electrosynthesis or substitution reactions starting from bromobenzene derivatives. Recent advancements in catalytic methods have improved the efficiency and scalability of these processes, enabling the production of high-purity samples required for demanding applications. For instance, a study published in the Journal of Organic Chemistry demonstrated a highly efficient route using palladium-catalyzed cross-coupling reactions to synthesize this compound with excellent yields.

3-Bromo-4-methylbenzoic acid has found applications in drug discovery, particularly in the development of anti-inflammatory and anticancer agents. Its ability to act as a chiral auxiliary or template in asymmetric synthesis has been explored extensively. A notable example is its use in the construction of enantiomerically enriched compounds, which are critical for modern pharmacology.

In addition to pharmaceutical applications, 3-bromo-4-methylbenzoic acid has been employed in materials science to create advanced polymers and hybrid materials. For instance, researchers have utilized this compound as a monomer in the synthesis of conducting polymers, where its electron-withdrawing groups enhance electrical conductivity. Recent studies have also highlighted its potential as a precursor for metal-organic frameworks (MOFs), which are promising candidates for gas storage and catalysis.

The versatility of 3-bromo-4-methylbenzoic acid extends to its role as an intermediate in organic synthesis. Its bromine atom serves as an excellent leaving group, enabling various substitution reactions that lead to structurally complex molecules. This property has been exploited in the development of novel agrochemicals and industrial catalysts.

In conclusion, 3-bromo-4-methylbenzoic acid, with its unique chemical structure and versatile reactivity, continues to be a valuable compound in both academic research and industrial applications. As new synthetic methods and functionalization strategies emerge, this compound is poised to play an even greater role in advancing materials science and pharmacology.

• 586-35-6(2-Bromoterephthalic acid)
• 610-71-9(2,5-Dibromobenzoic acid)
• 7697-27-0(2-Bromo-4-methylbenzoic acid)
• 790230-04-5(4-Bromo-3-(hydroxymethyl)benzoic acid)
• 20871-01-6(2,5-dibromo-4-methylbenzoic acid)
• 13731-82-3(2,5-Dibromoterephthalic acid)
• 7697-28-1(4-Bromo-3-methylbenzoic acid)
• 67973-32-4(3,5-Dibromo-4-methylbenzoic acid)
• 91760-66-6(3-Bromo-4-formylbenzoic acid)
• 7697-32-7(4-Bromo-3,5-dimethylbenzoic Acid)