• 1. Aggregation, pretransitional behavior, and optical properties in the isotropic phase of lyotropic chromonic liquid crystals studied in high magnetic fields
  Tanya Ostapenko,Peter J. Collings,Samuel N. Sprunt,J. T. Gleeson Soft Matter, 2013,9, 9487-9498
• 2. An analysis of the WTC fires using CIB correlations and simple modeling
  JGQuintiere
• 3. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 4. An investigation of new infrared nonlinear optical material: BaCdSnSe4, and three new related centrosymmetric compounds: Ba2SnSe4, Mg2GeSe4, and Ba2Ge2S6?
  Kui Wu,Zhihua Yang,Shilie Pan Dalton Trans., 2015,44, 19856-19864
• 5. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549

• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides 3',5'-cyclic purine nucleotides
• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Cyclic purine nucleotides 3',5'-cyclic purine nucleotides

Comprehensive Overview of 8-Bromo-cAMP sodium salt (CAS No. 76939-46-3): Mechanism, Applications, and Research Insights

8-Bromo-cAMP sodium salt (CAS 76939-46-3) is a chemically modified derivative of cyclic adenosine monophosphate (cAMP), a pivotal secondary messenger in cellular signaling pathways. This sodium salt form enhances solubility and stability, making it a preferred choice for in vitro and in vivo studies. Researchers frequently utilize this compound to investigate cAMP-dependent protein kinase (PKA) activation, gene regulation, and metabolic processes. Its bromine substitution at the 8-position confers resistance to hydrolysis by phosphodiesterases, prolonging its biological activity—a critical feature for prolonged experimental observations.

The compound’s role in modulating cell proliferation and differentiation has garnered attention in fields like cancer research, neurobiology, and immunology. For instance, studies highlight its potential to inhibit tumor growth by disrupting cAMP signaling pathways in malignant cells. Additionally, 8-Bromo-cAMP is instrumental in exploring neuronal plasticity and synaptic transmission, aligning with current trends in neurodegenerative disease research, such as Alzheimer’s and Parkinson’s. These applications resonate with frequent search queries like "cAMP analogs in cancer therapy" or "PKA activators for neuroprotection," reflecting its relevance in cutting-edge science.

From a technical perspective, 8-Bromo-cAMP sodium salt exhibits high purity (≥95% by HPLC) and is typically supplied as a white lyophilized powder. Its molecular formula (C₁₀H₁₁BrN₅NaO₆P) and molecular weight (432.09 g/mol) are key identifiers for procurement and experimental design. Storage recommendations (?20°C, desiccated) ensure longevity, while its water solubility (≥10 mg/mL) facilitates cell culture and biochemical assays. Such details address common user concerns like "how to dissolve 8-Bromo-cAMP" or "stability of cAMP analogs," enhancing the article’s practical utility.

Emerging trends in personalized medicine and drug discovery further underscore the compound’s significance. For example, its ability to mimic endogenous cAMP makes it a valuable tool for screening GPCR (G-protein-coupled receptor) targets—a hotspot in pharmaceutical development. Searches for "cAMP analogs in drug development" or "GPCR signaling tools" often lead to discussions involving 8-Bromo-cAMP sodium salt, reinforcing its interdisciplinary appeal.

In summary, 8-Bromo-cAMP sodium salt (CAS 76939-46-3) bridges fundamental research and translational applications. Its robust chemical properties, coupled with broad biological relevance, position it as a staple in laboratories exploring cell signaling, disease mechanisms, and therapeutic innovation. By addressing both technical specifications and trending scientific queries, this overview caters to diverse audiences—from graduate students to seasoned investigators—while optimizing SEO visibility through strategic keyword integration.

• 129735-00-8(Adenosine, 8-bromo-,cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate] (9CI))
• 143832-09-1(Ppp-AA)
• 114697-05-1(Siloxanes and Silicones, lauryl Me, Me hydrogen, Me 3-(oxiranylmethoxy)propyl, Me 2-phenylpropyl)
• 123334-12-3(8-Bromoadenosine 3',5'-Cyclic Monophosphate Sodium Salt Monohydrate)
• 37839-81-9(Adenosine 3’,5’-Cyclic Monophosphate Sodium Salt)
• 23583-48-4(8-Bromoadenosine 3',5'-Cyclic Monophosphate)
• 24493-93-4(9H-Purin-6-amine,9-(3,5-O-phosphinico-b-D-xylofuranosyl)- (9CI))
• 23600-16-0(Adenosine 5'-(trihydrogen diphosphate), 8-bromo- (9CI))
• 23583-49-5(2'-Adenylic acid,8-bromo- (9CI))
• 23567-96-6(8-Bromo-AMP)