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  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 3. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 4. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
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• Other Chemical Reagents Derivatization Reagents
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Introduction to (3-fluorophenyl)boronic Acid (CAS No. 768-35-4)

(3-fluorophenyl)boronic acid is a significant compound in the field of organic chemistry and pharmaceutical research, characterized by its molecular formula C₆H₅BF₂O₂ and a CAS number of 768-35-4. This boronic acid derivative has garnered considerable attention due to its versatile applications in synthetic chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, which are pivotal for constructing complex molecular architectures in drug development.

The 3-fluorophenyl substituent imparts unique electronic properties to the molecule, making it a valuable intermediate in the synthesis of fluorinated pharmaceuticals. Fluorine atoms are frequently incorporated into drug molecules to enhance metabolic stability, improve binding affinity, and modulate pharmacokinetic profiles. The presence of the boronic acid functional group further facilitates its role as a key building block in various chemical transformations.

In recent years, the pharmaceutical industry has witnessed a surge in the demand for boronic acid derivatives due to their utility in targeted drug delivery systems and as intermediates for antiviral and anticancer agents. The (3-fluorophenyl)boronic acid derivative, in particular, has been explored for its potential in developing novel therapeutics that leverage the benefits of boron-containing compounds.

One of the most prominent applications of (3-fluorophenyl)boronic acid is in the context of photodynamic therapy (PDT), where it serves as a precursor for designing photosensitizers that can selectively target and destroy cancer cells. The fluorine atom's electron-withdrawing effect enhances the compound's ability to absorb light at specific wavelengths, thereby improving the efficiency of PDT treatments. Recent studies have demonstrated its efficacy in combination with other therapeutic modalities, such as chemotherapy and radiation therapy.

The compound's reactivity also makes it an excellent candidate for material science applications. For instance, it has been utilized in the synthesis of organic electronic materials, where its ability to form stable bonds with other organic molecules contributes to the development of more durable and efficient electronic devices. Researchers have reported its use in creating conductive polymers and organic semiconductors that exhibit superior performance characteristics.

From an academic research perspective, (3-fluorophenyl)boronic acid continues to be a subject of extensive investigation. Scientists are exploring novel synthetic pathways to optimize its production and purity, ensuring that it meets the stringent requirements of pharmaceutical manufacturing. Additionally, computational studies have been conducted to elucidate its mechanistic pathways, providing insights into how it interacts with other molecules during chemical reactions.

The integration of (3-fluorophenyl)boronic acid into drug discovery pipelines has been particularly noteworthy. Its role as a chiral auxiliary in asymmetric synthesis has enabled the production of enantiomerically pure compounds, which are often essential for achieving desired pharmacological effects. Furthermore, its compatibility with green chemistry principles has made it an attractive choice for sustainable drug development practices.

In conclusion, (3-fluorophenyl)boronic acid stands out as a multifaceted compound with broad applications across various scientific disciplines. Its unique structural and electronic properties make it indispensable in pharmaceutical research, material science, and advanced chemical synthesis. As our understanding of its capabilities continues to evolve, so too will its contributions to innovation and therapeutic advancements.

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