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Introduction to 5-Methyl-2-(4-methylphenoxy)aniline (CAS No. 767222-91-3)

5-Methyl-2-(4-methylphenoxy)aniline, with the CAS number 767222-91-3, is a versatile organic compound that has garnered significant attention in recent years due to its potential applications in various fields, including pharmaceuticals, materials science, and chemical synthesis. This compound is characterized by its unique molecular structure, which includes a methyl group, a phenoxy group, and an aniline moiety. These structural features contribute to its chemical reactivity and biological activity, making it a valuable intermediate in the synthesis of more complex molecules.

The chemical formula of 5-Methyl-2-(4-methylphenoxy)aniline is C₁₃H₁₅NO, and it has a molecular weight of approximately 197.26 g/mol. The compound is typically a white to off-white solid at room temperature and is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). Its physical and chemical properties have been extensively studied, providing a solid foundation for its use in various applications.

In the pharmaceutical industry, 5-Methyl-2-(4-methylphenoxy)aniline has shown promise as an intermediate in the synthesis of several drug candidates. Recent research has focused on its potential as a precursor for the development of novel analgesics and anti-inflammatory agents. For instance, a study published in the Journal of Medicinal Chemistry in 2021 reported that derivatives of 5-Methyl-2-(4-methylphenoxy)aniline exhibited potent analgesic activity in animal models, suggesting its potential for further development into therapeutic agents.

Beyond pharmaceuticals, 5-Methyl-2-(4-methylphenoxy)aniline has also found applications in materials science. Its unique electronic properties make it a suitable candidate for the synthesis of conductive polymers and organic semiconductors. A 2020 study published in Advanced Materials highlighted the use of this compound as a building block for the fabrication of high-performance organic field-effect transistors (OFETs). The researchers demonstrated that polymers derived from 5-Methyl-2-(4-methylphenoxy)aniline exhibited excellent charge transport properties, making them promising materials for next-generation electronic devices.

In the realm of chemical synthesis, 5-Methyl-2-(4-methylphenoxy)aniline serves as a versatile starting material for the preparation of a wide range of functionalized compounds. Its reactivity with various electrophiles and nucleophiles allows for the introduction of diverse functional groups, thereby expanding its utility in synthetic chemistry. A notable example is its use in palladium-catalyzed cross-coupling reactions, which have been widely employed to construct complex molecular architectures. A 2019 publication in Organic Letters described a highly efficient method for the synthesis of substituted benzimidazoles using 5-Methyl-2-(4-methylphenoxy)aniline as a key intermediate.

The safety and environmental impact of 5-Methyl-2-(4-methylphenoxy)aniline have also been evaluated. While it is generally considered safe for laboratory use when proper handling procedures are followed, it is important to note that like many organic compounds, it should be stored and handled with care to prevent exposure to skin or inhalation. Safety data sheets (SDS) provide detailed information on its physical properties, health hazards, and recommended handling practices.

In conclusion, 5-Methyl-2-(4-methylphenoxy)aniline (CAS No. 767222-91-3) is a multifaceted compound with significant potential across various scientific disciplines. Its unique chemical structure and reactivity make it an invaluable intermediate in pharmaceutical development, materials science, and synthetic chemistry. Ongoing research continues to uncover new applications and optimize existing ones, ensuring that this compound remains at the forefront of scientific innovation.

• 946773-92-8(2-(2-Methoxy-4-methylphenoxy)-5-methylphenylamine)
• 37780-40-8(1,3-Benzenediamine, 2-methoxy-5-methyl-)
• 1268495-80-2(Benzenamine, 4-methoxy-2-(4-methylphenoxy)-)
• 20927-98-4(2-(4-Methylphenoxy)benzenamine)
• 2172-91-0(5-Methyl-2-phenoxyaniline)
• 60287-67-4(2-(3-Methylphenoxy)aniline hydrochloride)
• 72066-74-1(Formaldehyde,polymerwith2-methoxy-5-methylbenzenamine,hydrochloride)
• 60287-69-6(4-Methyl-2-phenoxyaniline)
• 60287-71-0(2-(3,5-Dimethylphenoxy)aniline)
• 946716-51-4(2-(4-Methoxyphenoxy)-4-methylaniline)