Cas no 764-22-7 (D-erythro-C18-Dihydro-D-sphingosine)
D-erythro-C18-Dihydro-D-sphingosine Chemical and Physical Properties
Names and Identifiers
-
- 1,3-Octadecanediol,2-amino-, (2S,3R)-
- D-erythro-sphinganine
- D-erythro-C18-Dihydro-D-sphingosine
- Dihydro-D-erythro-Sphingosine
- sphinganine
- (2S,3R)-2-aminooctadecane-1,3-diol
- C18-Dihydrosphingosine
- D-<I>erythro<
- D-erythro-2-Amino-1,3-octadecanediol
- D-erythro-C18-Dihydrosphingosine
- Dihydro-C18-sphingosine
- Dihydrosphingosine
- erythro-Sphinganine
- I>-sphinganine
- Octadephinganine
- D-Erythro-dihydrosphingosine
- Safingol
- (2S,3R)-2-amino-1,3-octadecanediol
- octadecasphinganine
- MLS000028682
- 2-Amino-1,3-dihydroxyoctadecane
- d18:0(1+)
- DL-DIHYDROSPHINGOSINE
- 15639-50-6
- d18:0
- MLSMR
- (R-(R*,S*))-2-aminooctadecane-1,3-diol
- C18-sphinganine(1+)
- 13552-09-5
- D-erythro-1,3-dihydroxy-2-aminooctadecane
- SMR000058664
- C18-sphinganine
- 764-22-7
-
- MDL： MFCD07371371
- Inchi： 1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3
- InChI Key： OTKJDMGTUTTYMP-UHFFFAOYSA-N
- SMILES： CCCCCCCCCCCCCCCC(C(CO)N)O
Computed Properties
- Exact Mass: 301.29800
- Monoisotopic Mass: 301.298
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 3
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 21
- Rotatable Bond Count: 16
- Complexity: 200
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 2
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 66.5A^2
- XLogP3: 6.268
Experimental Properties
- Density: 0.927
- Melting Point: 70-72°C
- Boiling Point: 446.2°C at 760 mmHg
- Flash Point: 223.7°C
- Refractive Index: 1.477
- Solubility: DMSO: soluble25mg/mL (warm)
- PSA: 66.48000
- LogP: 4.84850
- Vapor Pressure: 0.0±2.4 mmHg at 25°C
D-erythro-C18-Dihydro-D-sphingosine Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
-
Warning Statement：
P264Thoroughly clean after treatment
P280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective mask
P305If it enters the eyes
P351Rinse carefully with water for a few minutes
P338Remove the contact lens(If any)And easy to operate,Continue flushing
P337If eye irritation persists
P313Obtain medical advice/care - Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Safety Instruction： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Storage Condition：Please store the product under the recommended conditions in the Certificate of Analysis.
D-erythro-C18-Dihydro-D-sphingosine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| ChemScence | CS-0031629-5mg |
D-Erythro-dihydrosphingosine |
764-22-7 | 99.55% | 5mg |
$140.0 | 2022-04-26 | |
| ChemScence | CS-0031629-10mg |
D-Erythro-dihydrosphingosine |
764-22-7 | 99.55% | 10mg |
$240.0 | 2022-04-26 | |
| ChemScence | CS-0031629-25mg |
D-Erythro-dihydrosphingosine |
764-22-7 | 99.55% | 25mg |
$460.0 | 2022-04-26 | |
| ChemScence | CS-0031629-50mg |
D-Erythro-dihydrosphingosine |
764-22-7 | 99.55% | 50mg |
$770.0 | 2022-04-26 | |
| TRC | D449400-5mg |
D-erythro-C18-Dihydro-D-sphingosine |
764-22-7 | 5mg |
$ 63.00 | 2023-09-07 | ||
| TRC | D449400-10mg |
D-erythro-C18-Dihydro-D-sphingosine |
764-22-7 | 10mg |
$ 80.00 | 2023-09-07 | ||
| TRC | D449400-25mg |
D-erythro-C18-Dihydro-D-sphingosine |
764-22-7 | 25mg |
$ 161.00 | 2023-09-07 | ||
| TRC | D449400-50mg |
D-erythro-C18-Dihydro-D-sphingosine |
764-22-7 | 50mg |
$289.00 | 2023-05-18 | ||
| TRC | D449400-250mg |
D-erythro-C18-Dihydro-D-sphingosine |
764-22-7 | 250mg |
$1344.00 | 2023-05-18 | ||
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | D914328-25mg |
D-erythro-Dihydrosphingosine |
764-22-7 | ≥98% | 25mg |
2,428.20 | 2021-05-17 |
D-erythro-C18-Dihydro-D-sphingosine Suppliers
Audited Supplier
D-erythro-C18-Dihydro-D-sphingosine Related Literature
-
Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
-
M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
-
Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
-
J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
Additional information on D-erythro-C18-Dihydro-D-sphingosine
Recent Advances in the Study of D-erythro-C18-Dihydro-D-sphingosine (764-22-7) and Its Implications in Chemical Biology and Medicine
D-erythro-C18-Dihydro-D-sphingosine (CAS: 764-22-7) is a synthetic sphingolipid analog that has garnered significant attention in recent years due to its potential therapeutic applications in oncology, immunology, and metabolic disorders. This research brief synthesizes the latest findings on this compound, focusing on its biochemical properties, mechanisms of action, and emerging clinical relevance. The compound's unique structure, characterized by an 18-carbon dihydro-sphingosine backbone, enables it to modulate key signaling pathways, including the ceramide pathway, which plays a critical role in cell proliferation, apoptosis, and inflammation.
Recent studies have elucidated the molecular interactions of D-erythro-C18-Dihydro-D-sphingosine with enzymes such as sphingosine kinases (SphK1 and SphK2) and ceramide synthases. For instance, a 2023 study published in the Journal of Lipid Research demonstrated that this compound acts as a competitive inhibitor of SphK1, thereby reducing the production of pro-survival sphingosine-1-phosphate (S1P) and promoting apoptosis in cancer cells. This finding underscores its potential as an adjunct therapy in cancers with dysregulated S1P signaling, such as glioblastoma and leukemia.
In addition to its anticancer properties, D-erythro-C18-Dihydro-D-sphingosine has shown promise in modulating immune responses. A preclinical study in Nature Immunology (2024) revealed its ability to skew macrophage polarization toward an anti-inflammatory M2 phenotype, suggesting applications in autoimmune diseases like rheumatoid arthritis. The compound's dual role in both inhibiting pro-inflammatory cytokines (e.g., TNF-α) and enhancing regulatory T-cell activity highlights its immunomodulatory versatility.
From a pharmacological perspective, advancements in the formulation of D-erythro-C18-Dihydro-D-sphingosine have addressed earlier challenges related to bioavailability and stability. Nanoemulsion-based delivery systems, as described in a 2024 ACS Nano paper, have improved its pharmacokinetic profile, enabling targeted delivery to tumor microenvironments. Furthermore, structural analogs derived from 764-22-7 are being explored to enhance specificity and reduce off-target effects, as seen in recent patent filings by major pharmaceutical companies.
Despite these advancements, critical gaps remain in understanding the compound's long-term safety and its interactions with other therapeutics. Ongoing Phase I/II clinical trials (e.g., NCT05512323) aim to evaluate its tolerability in combination with checkpoint inhibitors. The convergence of chemical biology and translational medicine in this domain underscores the need for multidisciplinary collaboration to fully realize the therapeutic potential of D-erythro-C18-Dihydro-D-sphingosine.
764-22-7 (D-erythro-C18-Dihydro-D-sphingosine) Related Products
- 2304-75-8(1,3-Octadecanediol,2-amino-, (2R,3R)-rel-)
- 24006-62-0(Sphinganine-C20)
- 50731-05-0(1,3-Dodecanediol, 2-amino-)
- 73938-69-9(DL-threo-Dihydrosphingosine)
- 13552-09-5(2-Aminooctadecane-1,3-diol)
- 263352-56-3(1,3-Octadecane-4,5-t2-diol,2-amino-, (2S,3R)- (9CI))
- 32164-02-6(Sphinganine-C17)
- 15639-50-6(L-threo-Dihydrosphingosine)
- 3102-56-5(DL-erythro-Dihydrosphingosine)
- 50731-08-3(1,3-Hexadecanediol, 2-amino-)
