• 1. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?
  Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
• 2. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 3. An antioxidative galactomannan extracted from Chinese Sesbania cannabina enhances immune activation of macrophage cells?
  Chongyang Zhu,Xiaojia Bian,Xin Jia,Ning Tang,Yongqiang Cheng Food Funct., 2020,11, 10635-10644
• 4. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 5. An approach to asymmetric synthesis of β-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement?
  Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Cyclohexylamines

Trans-2-(4-Aminocyclohexyl)Acetic Acid Hydrochloride: A Comprehensive Overview

Trans-2-(4-aminocyclohexyl)acetic acid hydrochloride, identified by the CAS number 76325-96-7, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound, which exists as a hydrochloride salt, is characterized by its unique structure, featuring a cyclohexane ring substituted with an amino group and a trans-configured acetic acid moiety. The molecule's stereochemistry plays a crucial role in its biological activity and pharmacokinetic properties.

Recent studies have highlighted the potential of trans-2-(4-aminocyclohexyl)acetic acid hydrochloride as a precursor or intermediate in the synthesis of bioactive compounds. Its ability to participate in various chemical reactions, such as nucleophilic substitutions and condensations, makes it a valuable building block in drug discovery processes. Researchers have explored its applications in the development of peptide-based drugs, where its amino group can serve as a site for further functionalization.

The synthesis of trans-2-(4-aminocyclohexyl)acetic acid hydrochloride typically involves multi-step reactions, including cyclohexane ring formation, substitution reactions, and acid-base neutralization to form the hydrochloride salt. The stereochemistry of the compound is carefully controlled during synthesis to ensure the desired trans configuration, which is critical for its intended applications.

In terms of biological activity, trans-2-(4-aminocyclohexyl)acetic acid hydrochloride has shown promise in preclinical studies as a substrate for enzymes involved in amino acid metabolism. Its interaction with specific enzymes has been investigated to understand its role in metabolic pathways and potential therapeutic interventions. Additionally, the compound's solubility and stability under various conditions have been evaluated to assess its suitability for formulation into pharmaceutical products.

Recent advancements in computational chemistry have enabled researchers to model the molecular interactions of trans-2-(4-aminocyclohexyl)acetic acid hydrochloride with target proteins. These studies provide insights into its binding affinity and selectivity, which are essential for optimizing its use in drug design. Furthermore, the compound's pharmacokinetic profile has been studied to determine its absorption, distribution, metabolism, and excretion (ADME) properties, which are critical for evaluating its potential as a therapeutic agent.

The application of trans-2-(4-aminocyclohexyl)acetic acid hydrochloride extends beyond drug discovery. It has also been utilized as a chiral auxiliary in asymmetric synthesis, where its stereochemistry facilitates the formation of enantiomerically enriched compounds. This approach has proven particularly useful in the synthesis of complex natural products and biologically active molecules.

In conclusion, trans-2-(4-aminocyclohexyl)acetic acid hydrochloride, with its unique structure and versatile properties, continues to be a focal point in chemical research. Its role as a building block in drug discovery, combined with its potential applications in metabolic studies and asymmetric synthesis, underscores its importance in advancing scientific knowledge and therapeutic development.

• 905589-96-0(Nonanoic acid, 8-methyl-, compd. with cyclohexanamine (1:1))
• 25038-97-5(Dodecanedioic acid polymer with 4,4'-methylenebis[cyclohexanamine])
• 1197-54-2(2-(4-Aminocyclohexyl)acetic acid)
• 2611-77-0(3-(4-Aminocyclohexyl)propanoic acid)
• 61367-39-3(cis-2-(4-aminocyclohexyl)acetic acid;hydrochloride)
• 93820-48-5(isononanoic acid, compound with cyclohexylamine (1:1))
• 2952-00-3(2-(1r,4r)-4-aminocyclohexylacetic acid)
• 93820-43-0(isooctanoic acid, compound with cyclohexylamine (1:1))
• 109572-36-3(2-(4-aminocyclohexyl)acetic acid hydrochloride)
• 2952-01-4(2-(1s,4s)-4-aminocyclohexylacetic acid, cis)