• 1. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 2. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 3. Enantiopure 2,6-disubstituted piperidines bearing one alkene- or alkyne-containing substituent: preparation and application to total syntheses of indolizidine-alkaloids?
  Hui Liu,Deyong Su,Guolin Cheng,Jimin Xu,Xinyan Wang,Yuefei Hu Org. Biomol. Chem., 2010,8, 1899-1904
• 4. Distribution and ecological risk assessment of typical antibiotics in the surface waters of seven major rivers, China?
  Environ. Sci.: Processes Impacts, 2021,23, 1088-1100
• 5. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Sugar acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates Sugar acids and derivatives

Rac-Ethyl (1R,2R,5S)-3-Azabicyclo[3.1.0]Hexane-2-Carboxylate: A Comprehensive Overview

The compound rac-ethyl (1R,2R,5S)-3-azabicyclo[3.1.0]hexane-2-carboxylate (CAS No. 76319-28-3) is a unique bicyclic compound with significant potential in various chemical and pharmaceutical applications. This compound belongs to the class of bicyclic amines and is characterized by its rigid bicyclic structure, which plays a crucial role in its biological activity and chemical reactivity.

The bicyclic structure of this compound is a key feature that contributes to its stability and selectivity in various reactions. The azabicyclo[3.1.0]hexane framework is a six-membered ring system with one nitrogen atom, creating a rigid and strained environment that enhances its reactivity in certain chemical transformations. Recent studies have shown that such bicyclic systems are highly valuable in the design of novel bioactive molecules due to their ability to mimic natural product frameworks.

One of the most notable aspects of rac-ethyl (1R,2R,5S)-3-azabicyclo[3.1.0]hexane-2-carboxylate is its stereochemistry. The compound exists as a racemic mixture, meaning it contains equal amounts of the two enantiomers: (1R,2R,5S) and (1S,2S,5R). This stereochemical property is critical in pharmaceutical applications, where the stereochemistry of a molecule can significantly influence its pharmacokinetics and efficacy.

Recent advancements in synthetic chemistry have enabled the efficient synthesis of this compound through various methodologies. For instance, researchers have employed ring-closing metathesis and stereoselective alkylation techniques to construct the azabicyclo framework with high precision. These methods not only enhance the yield but also allow for better control over the stereochemistry of the final product.

In terms of applications, rac-ethyl (1R,2R,5S)-3-azabicyclo[3.1.0]hexane-2-carboxylate has shown promise in drug discovery programs targeting various therapeutic areas. Its rigid structure makes it an ideal candidate for designing molecules with high binding affinity to specific biological targets such as enzymes and receptors.

Moreover, this compound has been extensively studied for its potential as a building block in medicinal chemistry. Its ability to undergo various functional group transformations makes it versatile for constructing complex molecular architectures. For example, researchers have utilized this compound as a starting material for synthesizing bioactive agents with potential anti-inflammatory and anticancer properties.

The carboxylate group present in this compound adds another layer of functionality by enabling further modifications such as esterification or amidation. These modifications can significantly alter the physicochemical properties of the molecule, making it suitable for different biological assays and pharmacological evaluations.

In conclusion, rac-ethyl (1R,2R,5S)-3-azabicyclo[3.1.0]hexane-2-carboxylate is a versatile and intriguing compound with a wide range of applications in organic synthesis and drug discovery. Its unique bicyclic structure, stereochemical properties, and functional versatility make it an invaluable tool for researchers in the field of chemical biology.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)