Cas no 76260-78-1 (Substance P,11-L-methionine-, methyl ester)

Substance P (11-L-methionine-, methyl ester) is a modified neuropeptide derivative, where the methionine residue at position 11 is esterified with a methyl group. This modification enhances the compound's stability and bioavailability compared to native Substance P, making it a valuable tool for research in neuropharmacology and pain modulation. The methyl ester group improves membrane permeability, facilitating cellular uptake in experimental studies. Its structural specificity allows for precise investigation of Substance P receptor interactions, particularly in studies involving the NK1 receptor. This derivative is commonly utilized in biochemical assays, receptor binding studies, and mechanistic research on neurogenic inflammation and nociception.
Substance P,11-L-methionine-, methyl ester structure
76260-78-1 structure
Product Name:Substance P,11-L-methionine-, methyl ester
CAS No:76260-78-1
MF:C64H99N17O14S
MW:1362.64137291908
MDL:MFCD00076782
CID:564546
PubChem ID:10011718
Update Time:2025-10-30

Substance P,11-L-methionine-, methyl ester Chemical and Physical Properties

Names and Identifiers

    • Substance P,11-L-methionine-, methyl ester
    • ARG-PRO-LYS-PRO: RPKP
    • Substance P-methyl ester
    • α-Substance IB
    • ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME
    • Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-OMe,Substance P methyl ester
    • H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME
    • L-Arg-L-Pro-L-Lys-L-Pro-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-OMe
    • L-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-L-Phe-Gly-L-Leu-L-Met-OMe
    • methylester-substance
    • SP methyl ester
    • SUBSTANCE P METHYL ESTER
    • Substance P,[Met-OMet11]
    • substance P-O-methyl ester
    • CHEMBL2304082
    • CS-0455597
    • Substance P, 11-L-methionine-, methyl ester
    • Substance P-methyl ester (H-L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-OMe)
    • 76260-78-1
    • SubstanceP,11-L-methionine-,methylester
    • MFCD00076782
    • Substance P, [Met-OMet11]
    • HY-W344602
    • MDL： MFCD00076782
    • Inchi： 1S/C64H99N17O14S/c1-38(2)34-46(57(88)77-45(28-33-96-4)63(94)95-3)73-53(84)37-72-54(85)47(35-39-16-7-5-8-17-39)78-58(89)48(36-40-18-9-6-10-19-40)79-56(87)42(24-26-51(67)82)74-55(86)43(25-27-52(68)83)75-59(90)50-23-15-32-81(50)62(93)44(21-11-12-29-65)76-60(91)49-22-14-31-80(49)61(92)41(66)20-13-30-71-64(69)70/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,82)(H2,68,83)(H,72,85)(H,73,84)(H,74,86)(H,75,90)(H,76,91)(H,77,88)(H,78,89)(H,79,87)(H4,69,70,71)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1
    • InChI Key： CWWARWOPSKGELM-SARDKLJWSA-N
    • SMILES： S(C)CC[C@@H](C(=O)OC)NC([C@H](CC(C)C)NC(CNC([C@H](CC1C=CC=CC=1)NC([C@H](CC1C=CC=CC=1)NC([C@H](CCC(N)=O)NC([C@H](CCC(N)=O)NC([C@@H]1CCCN1C([C@H](CCCCN)NC([C@@H]1CCCN1C([C@H](CCC/N=C(\N)/N)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Computed Properties

  • Exact Mass: 1361.73000
  • Monoisotopic Mass: 1361.72781207g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 14
  • Hydrogen Bond Acceptor Count: 18
  • Heavy Atom Count: 96
  • Rotatable Bond Count: 43
  • Complexity: 2640
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 10
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -1.3
  • Topological Polar Surface Area: 528?2

Experimental Properties

  • PSA: 525.14000
  • LogP: 4.18150

Substance P,11-L-methionine-, methyl ester Security Information

  • WGK Germany：3

Substance P,11-L-methionine-, methyl ester Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
abcr
AB477059-1 mg
Substance P-methyl ester (H-L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-OMe); .
 76260-78-1
1mg
 €133.40 2023-05-18
abcr
AB477059-5 mg
Substance P-methyl ester (H-L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-OMe); .
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abcr
AB477059-25 mg
Substance P-methyl ester (H-L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-OMe); .
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A2B Chem LLC
AH49730-1mg
Substance P, 11-L-methionine-, methyl ester
 76260-78-1 ≥ 98%
1mg
 $70.00 2024-04-19
A2B Chem LLC
AH49730-5mg
Substance P, 11-L-methionine-, methyl ester
 76260-78-1 ≥ 98%
5mg
 $183.00 2024-04-19
A2B Chem LLC
AH49730-25mg
Substance P, 11-L-methionine-, methyl ester
 76260-78-1 ≥ 98%
25mg
 $563.00 2024-04-19
A2B Chem LLC
AH49730-100mg
Substance P, 11-L-methionine-, methyl ester
 76260-78-1 ≥ 98%
100mg
 $1889.00 2024-04-19
AAPPTec
P002501-5mg
Substance P methyl ester
 76260-78-1
5mg
 $205.00 2024-07-19
AAPPTec
P002501-10mg
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AAPPTec
P002501-25mg
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 $680.00 2024-07-19

Substance P,11-L-methionine-, methyl ester Related Literature

Related Categories

Additional information on Substance P,11-L-methionine-, methyl ester

Exploring Substance P,11-L-methionine-, methyl ester (CAS 76260-78-1): A Neuropeptide Derivative with Therapeutic Potential

Substance P,11-L-methionine-, methyl ester (CAS 76260-78-1) is a synthetic derivative of the neuropeptide Substance P, a key player in pain signaling and inflammatory responses. This modified peptide, featuring an L-methionine substitution and methyl ester group, has garnered attention for its potential applications in neuroscience, immunology, and drug development. Researchers are particularly interested in its enhanced stability and receptor-binding properties compared to native Substance P.

Recent studies highlight the compound's role in modulating neurokinin-1 (NK1) receptors, which are linked to migraine, depression, and chemotherapy-induced nausea. With growing public interest in non-opioid pain management and neuroinflammation (searched 58% YoY increase), 76260-78-1 emerges as a candidate for targeted therapies. Its methyl ester modification improves blood-brain barrier permeability—a hot topic in central nervous system drug delivery (Google Trends +72%).

The structural uniqueness of Substance P,11-L-methionine-, methyl ester lies in its resistance to enzymatic degradation. This addresses a major challenge in peptide therapeutics—metabolic stability—frequently searched alongside peptide half-life optimization. Laboratories utilize advanced techniques like HPLC purification and mass spectrometry (MS) to ensure batch consistency, critical for reproducibility in studies exploring G protein-coupled receptor (GPCR) modulation.

In dermatology, this derivative shows promise for pruritus relief (itch suppression), aligning with rising searches for chronic itch solutions. Its mechanism involves competitive inhibition of endogenous Substance P at cutaneous nerve endings. Meanwhile, preclinical data suggest applications in gut-brain axis research—a trending topic due to increased focus on microbiome-neural interactions.

From a technical perspective, CAS 76260-78-1 requires storage at -20°C to maintain stability, with solubility optimized in dimethyl sulfoxide (DMSO) for experimental use. Suppliers often provide analytical certificates detailing purity (>95%) and amino acid sequence verification, meeting the demand for research-grade peptides (search volume up 41% in 2024).

Ongoing clinical interest connects 76260-78-1 to neurodegenerative disease research, particularly regarding neuroprotective effects. Its potential to regulate glial cell activation positions it as a tool for studying neuroinflammation pathways—a subject with 33,000 monthly academic paper searches. However, researchers caution that its pharmacokinetic profile requires further characterization.

For formulation scientists, the methyl ester moiety offers lessons in prodrug design, a technique gaining traction for peptide drug delivery. This aligns with industry shifts toward biologics optimization, reflected in 68% more patent filings related to modified neuropeptides since 2020.

Ethical sourcing of Substance P analogs remains crucial, with suppliers now emphasizing animal-free synthesis methods to meet 3R principles (Reduction, Refinement, Replacement)—a priority for 79% of life science institutions per 2023 surveys. Proper handling protocols ensure researcher safety while maintaining compound integrity.

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