• 1. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
  Joseph W. Bennett,Diamond T. Jones,Blake G. Hudson,Joshua Melendez-Rivera,Robert J. Hamers,Sara E. Mason Environ. Sci.: Nano, 2020,7, 1642-1651
• 2. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 3. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 4. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 5. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Aminophenyl ethers

4-(Cyclohexylmethoxy)aniline (CAS 76253-28-6): Properties, Applications, and Market Insights

4-(Cyclohexylmethoxy)aniline (CAS 76253-28-6) is a specialized organic compound with a unique molecular structure that combines an aniline core with a cyclohexylmethoxy substituent. This chemical has garnered significant attention in recent years due to its versatile applications in pharmaceuticals, agrochemicals, and material science. Researchers and industry professionals frequently search for terms like "4-(cyclohexylmethoxy)aniline synthesis", "CAS 76253-28-6 properties", and "aniline derivatives applications", reflecting the growing interest in this compound.

The molecular formula of 4-(cyclohexylmethoxy)aniline is C₁₃H₁₉NO, with a molecular weight of 205.30 g/mol. Its chemical structure features an amino group (-NH₂) attached to a benzene ring, which is further substituted at the para position by a cyclohexylmethoxy group. This particular arrangement contributes to its interesting physicochemical properties, including moderate solubility in organic solvents and a melting point typically ranging between 45-55°C. Recent studies have focused on "4-(cyclohexylmethoxy)aniline solubility" and "stability under various conditions", as these factors are crucial for its industrial applications.

In the pharmaceutical sector, 4-(cyclohexylmethoxy)aniline serves as a valuable building block for drug development. Its structural features make it particularly useful as an intermediate in the synthesis of various therapeutic agents. Current research trends show increased interest in "pharmaceutical intermediates 2023" and "aniline derivatives in drug discovery", highlighting the relevance of this compound. The cyclohexylmethoxy moiety often contributes to improved pharmacokinetic properties in drug molecules, making this intermediate highly sought after by medicinal chemists.

The agrochemical industry also benefits from 4-(cyclohexylmethoxy)aniline as a precursor for certain pesticides and herbicides. With the global push toward "sustainable agriculture solutions" and "eco-friendly crop protection", the demand for specialized intermediates like this has grown substantially. The compound's ability to serve as a scaffold for more complex molecules makes it particularly valuable in developing new generation agrochemicals with improved efficacy and environmental profiles.

Material science applications of 4-(cyclohexylmethoxy)aniline include its use in the synthesis of advanced polymers and dyes. The compound's aromatic amine functionality allows it to participate in various polymerization reactions, while the cyclohexyl group can impart desirable physical properties to the resulting materials. Recent searches for "specialty chemicals for advanced materials" and "aniline-based polymers" demonstrate the ongoing relevance of such compounds in cutting-edge material development.

From a market perspective, the global demand for 4-(cyclohexylmethoxy)aniline has shown steady growth, particularly in regions with strong pharmaceutical and agrochemical manufacturing bases. Industry reports tracking "fine chemical market trends 2023" and "specialty intermediates growth" consistently highlight the importance of such structurally diverse aniline derivatives. The compound's niche applications and the need for customized synthesis routes contribute to its premium positioning in the chemical marketplace.

Quality control and analytical characterization of 4-(cyclohexylmethoxy)aniline typically involve techniques such as HPLC, GC-MS, and NMR spectroscopy. These methods ensure the compound meets the stringent purity requirements for pharmaceutical and agrochemical applications. The increasing focus on "chemical purity standards" and "analytical method development" in recent industry discussions underscores the importance of robust quality assurance protocols for intermediates like this.

Environmental and safety considerations for 4-(cyclohexylmethoxy)aniline follow standard chemical handling protocols. While not classified as highly hazardous, proper personal protective equipment and adequate ventilation are recommended during handling. The chemical industry's growing emphasis on "green chemistry principles" and "sustainable chemical manufacturing" has led to increased interest in developing more environmentally benign synthesis routes for such intermediates.

Future research directions for 4-(cyclohexylmethoxy)aniline may explore its potential in emerging applications such as organic electronics or as a ligand in catalytic systems. The compound's structural features make it an interesting candidate for these advanced applications, aligning with current searches for "new applications of aniline derivatives" and "specialty chemicals for electronics". As synthetic methodologies continue to advance, we can expect to see novel uses for this versatile intermediate.

In conclusion, 4-(cyclohexylmethoxy)aniline (CAS 76253-28-6) represents an important specialty chemical with diverse applications across multiple industries. Its unique combination of an aromatic amine with a cyclohexylmethoxy group provides valuable synthetic versatility that continues to attract research interest. As industry trends evolve toward more specialized and sustainable chemical solutions, intermediates like this will likely maintain their significance in both academic and industrial settings.

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