• 1. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
  Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
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  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388
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• Solvents and Organic Chemicals Organic Compounds Organohalogen compounds Aryl halides Aryl iodides

Comprehensive Overview of 2-Cyclopropyl-5-iodo-1H-imidazole (CAS No. 761426-65-7): Properties, Applications, and Research Insights

2-Cyclopropyl-5-iodo-1H-imidazole (CAS No. 761426-65-7) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. This iodo-substituted imidazole derivative features a unique cyclopropyl ring, which enhances its reactivity and potential as a building block in organic synthesis. Its molecular structure, C₆H₇IN₂, combines the versatility of the imidazole core with the strategic placement of iodine, making it a valuable intermediate for cross-coupling reactions such as Suzuki-Miyaura or Sonogashira couplings.

In recent years, the demand for halogenated imidazoles like 2-Cyclopropyl-5-iodo-1H-imidazole has surged due to their role in developing targeted therapeutics. Researchers are particularly interested in its potential applications in kinase inhibitor design, a hot topic in oncology drug discovery. The compound’s ability to modulate protein-protein interactions aligns with the growing focus on precision medicine, a trend frequently searched in academic and biotech circles. Additionally, its iodine atom offers opportunities for radiolabeling, a technique pivotal in PET imaging research.

The synthesis of 2-Cyclopropyl-5-iodo-1H-imidazole typically involves cyclopropanation of precursor imidazoles followed by regioselective iodination. Advanced purification techniques, such as column chromatography or HPLC, ensure high purity (>98%), a critical factor for reproducibility in medicinal chemistry. Stability studies indicate that the compound should be stored under inert conditions to prevent degradation, a detail often queried by laboratory professionals in chemical storage-related forums.

Beyond pharmaceuticals, this compound has exploratory uses in material science, particularly in designing organic semiconductors. Its conjugated system and halogenated moiety contribute to electron transport properties, a feature highlighted in recent publications on flexible electronics. This interdisciplinary relevance makes it a recurring keyword in grant proposals and patent applications.

Environmental and safety assessments of 2-Cyclopropyl-5-iodo-1H-imidazole emphasize its low ecotoxicity, aligning with the green chemistry principles increasingly demanded by regulatory bodies. Analytical methods like GC-MS and NMR are routinely employed for quality control, as verified by third-party laboratories—a point frequently raised in QA/QC discussions across LinkedIn groups and researchGate threads.

In summary, 2-Cyclopropyl-5-iodo-1H-imidazole (CAS No. 761426-65-7) represents a multifaceted tool for innovators addressing challenges in drug discovery, diagnostic imaging, and advanced materials. Its synthesis, applications, and safety profile continue to inspire scholarly debates, making it a compound of enduring scientific and industrial interest.

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