• 1. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 2. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 3. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 4. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 5. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Lactones Gamma butyrolactones

4-Iodo-6-oxabicyclo3.2.1octan-7-one: A Comprehensive Overview

The compound with CAS No 76140-13-1, commonly referred to as 4-Iodo-6-oxabicyclo3.2.1octan-7-one, is a unique bicyclic structure that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound belongs to the class of bicyclic ketones, characterized by its rigid bicyclo[3.2.1]octane skeleton with an oxygen atom at the 6-position and an iodo group at the 4-position. The bicyclo[3.2.1]octane framework is known for its stability and versatility, making it a valuable structure in various chemical applications.

Recent studies have highlighted the potential of 4-Iodo-6-oxabicyclo3.2.1octan-7-one in drug discovery, particularly in the development of bioactive molecules with anti-inflammatory and antioxidant properties. Researchers have explored its ability to act as a scaffold for designing novel therapeutic agents, leveraging its rigid structure to enhance molecular interactions with target proteins.

The synthesis of 4-Iodo-6-oxabicyclo3.2.1octan-7-one involves a multi-step process that typically begins with the preparation of the bicyclic core followed by functionalization at specific positions. One of the most efficient methods reported in the literature involves a Diels-Alder reaction to form the bicyclic system, followed by oxidation to introduce the ketone group at the 7-position and iodination at the 4-position using iodine-based reagents.

One of the most intriguing aspects of this compound is its ability to undergo various transformations while retaining its bicyclic framework. For instance, recent research has demonstrated that 4-Iodo-6-oxabicyclo3.2.1octan-7-one can serve as a versatile building block for constructing more complex molecules with potential medicinal applications. By replacing the iodo group with other functional groups, chemists can tailor the compound's properties for specific biological targets.

In terms of physical properties, 4-Iodo-6-oxabicyclo3.2.1octan-7-one exhibits a melting point of approximately 155°C and is sparingly soluble in common organic solvents such as dichloromethane and ethyl acetate. Its stability under various conditions makes it suitable for use in both laboratory settings and industrial applications.

From an environmental perspective, studies have shown that 4-Iodo-6-oxabicyclo3.2.1octan-7-one has a low toxicity profile, making it a safer alternative to other similar compounds in certain applications. This characteristic aligns with current trends toward green chemistry and sustainable practices in chemical synthesis.

Looking ahead, ongoing research into 4-Iodo-6-oxabicyclo3.2.1octan-7-one is focused on expanding its application in medicinal chemistry, particularly in the design of kinase inhibitors and other enzyme-targeting agents. Its rigid structure provides an ideal platform for optimizing molecular interactions, which is crucial for achieving high potency and selectivity in drug candidates.

In conclusion, 4-Iodo-6 oxabicyclo[3 2 1] octan 7 one (CAS No 76140 13 1) stands out as a promising compound with diverse applications across multiple disciplines within chemistry and pharmacology. Its unique structure, coupled with recent advancements in synthetic methodologies and biological evaluations, positions it as a key player in future innovations within these fields.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)