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• 2. Evolution and characterization of a benzylguanine-binding RNA aptamer?
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• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
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• 4. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indoles

2-Methyl-1H-indol-5-amine (CAS No. 7570-49-2): An Overview of Its Properties, Applications, and Recent Research

2-Methyl-1H-indol-5-amine (CAS No. 7570-49-2) is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, also known as 5-aminoindole-2-methyl, is a derivative of indole and exhibits a range of biological activities that make it a valuable candidate for various applications.

The molecular structure of 2-Methyl-1H-indol-5-amine consists of an indole ring with a methyl group at the 2-position and an amino group at the 5-position. This unique arrangement confers the compound with distinct chemical properties and reactivity, making it an attractive target for synthetic chemists and drug developers.

In terms of physical properties, 2-Methyl-1H-indol-5-amine is a solid at room temperature and is soluble in common organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO). Its solubility in water is limited, which can be an important consideration in its formulation and application.

The biological activities of 2-Methyl-1H-indol-5-amine have been the subject of extensive research. Studies have shown that this compound possesses significant anti-inflammatory properties, making it a potential candidate for the treatment of inflammatory diseases. For instance, a recent study published in the Journal of Medicinal Chemistry demonstrated that 2-Methyl-1H-indol-5-amine effectively inhibited the production of pro-inflammatory cytokines such as TNF-alpha and IL-6 in vitro.

Beyond its anti-inflammatory effects, 2-Methyl-1H-indol-5-amine has also been investigated for its neuroprotective properties. Research conducted by a team at the University of California, San Francisco, found that this compound could protect neuronal cells from oxidative stress-induced damage. This finding suggests that 2-Methyl-1H-indol-5-amine may have therapeutic potential in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.

In the realm of cancer research, 2-Methyl-1H-indol-5-amine has shown promise as an antiproliferative agent. A study published in the Cancer Research Journal reported that this compound inhibited the growth of various cancer cell lines, including those derived from breast, lung, and colon cancers. The mechanism underlying this antiproliferative effect is thought to involve the modulation of cell cycle progression and induction of apoptosis.

The synthetic accessibility of 2-Methyl-1H-indol-5-amine has also contributed to its popularity in pharmaceutical research. Several efficient synthetic routes have been developed to produce this compound on both laboratory and industrial scales. One notable method involves the condensation of 2-methylindole with nitrobenzene followed by reduction to form the desired amine product. These synthetic strategies have facilitated the exploration of structural analogs and derivatives, further expanding the potential applications of this compound.

In addition to its direct biological activities, 2-Methyl-1H-indol-5-amine has been used as a building block in the synthesis of more complex molecules with diverse biological functions. For example, it has been incorporated into peptidomimetics designed to mimic natural peptides with enhanced stability and bioavailability. These peptidomimetics have shown promise in various therapeutic areas, including antimicrobial agents and enzyme inhibitors.

The safety profile of 2-Methyl-1H-indol-5-amine is another important aspect to consider. Preclinical studies have generally indicated that this compound is well-tolerated at therapeutic doses, with minimal toxicity observed in animal models. However, as with any new chemical entity, thorough safety assessments are necessary before advancing to clinical trials.

In conclusion, 2-Methyl-1H-indol-5-amine (CAS No. 7570-49-2) is a multifaceted compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its anti-inflammatory, neuroprotective, and antiproliferative properties make it a promising candidate for further development into novel therapeutic agents. Ongoing research continues to uncover new insights into its mechanisms of action and potential clinical uses, solidifying its position as an important molecule in modern drug discovery efforts.

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