Cas no 755037-03-7 (Regorafenib)

Regorafenib is a small molecule kinase inhibitor used in the treatment of advanced solid tumors, offering potent anti-angiogenic and antiproliferative activities through selective inhibition of multiple kinases involved in tumor growth and metastasis. Its efficacy has been demonstrated in clinical settings with improved progression-free survival and overall response rates in refractory patients.
Regorafenib structure
Regorafenib structure
Product Name:Regorafenib
CAS No:755037-03-7
MF:C21H15ClF4N4O3
MW:482.81541
MDL:MFCD16038047
CID:820150
PubChem ID:354334233
Update Time:2025-09-01

Regorafenib Chemical and Physical Properties

Names and Identifiers

    • 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide
    • BAY 73-4506
    • 4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
    • BAY 73-4506(Regorafenib)
    • 4-[4-({[4-chioro-3-(trifluoroMethyl)phenyl]carbaMoyl}aMino)-3-fluorophenoxy]-pyridine-2-carboxylic acid MethylaMide
    • Regorafenib (BAY 73-4506)
    • 4-[4-[[[[4-Chloro-3-(trifluoroMethyl)phenyl]aMino]carbonyl]aMino]-3-fluorophenoxy]-N-Methyl-2-pyridinecarboxaMide
    • 4-[4-[N'-(4-Chloro-3-trifluoroMethylphenyl)ureido]-3- fluorophenoxy]pyridine-2-carboxylic Acid MethylaMide
    • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]-N-methylpyridine-2-carboxamide
    • Regorafenib
    • Regorafenib（BAY73-4506）
    • Regorafenib hydrate
    • BAY734506
    • FREE BASE
    • REGORAFENIB BAY 73-4506 BAYER HEALTHCARE (SEE ALSO COLORECTAL, LUNG, STOMACH) PHASE II(REGORAFENIB) PHARMACEUTICALS (888) 842-2937WAYNE, NJ
    • Regorafenib [USAN:INN]
    • CCG-269571
    • R0142
    • BAY73-4506 hydrochloride
    • 835621-08-4
    • DTXSID70144349
    • Stivarga
    • CHEBI:68647
    • AKOS015951107
    • NCGC00263138-13
    • GTPL5891
    • MFCD16038047
    • SCHEMBL432230
    • 4-(4-(((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl)amino)-3-fluorophenoxy)-n-methylpyridine-2-carboxamide
    • Regorafenib (BAY73-4506,Fluoro-Sorafenib)
    • BAY-73-4506
    • cas:835621-07-3;Regorafenib hydrochloride
    • CHEBI:68646
    • BCP9000384
    • BRD-K16730910-001-07-3
    • AC-31116
    • 24T2A1DOYB
    • NCGC00263138-01
    • Z2235801830
    • NSC-800865
    • AS-16304
    • 2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-
    • Regorafenib,BAY 73-4506
    • NSC800865
    • REGORAFENIB [MI]
    • BCPP000352
    • SDCCGSBI-0654355.P001
    • NSC763932
    • s1178
    • C21H15ClF4N4O3
    • HMS3654K16
    • BCP02105
    • 755037-03-7
    • UNII-MGN125FS9D
    • BRD-K16730910-001-02-4
    • Regorafenib-13C-d3
    • NSC-763932
    • HMS3672E15
    • L01XE21
    • HY-10331
    • 755037-03-7 (anhydrous); 1019206-88-2 (hydrate)
    • SMR004701370
    • UNII-24T2A1DOYB
    • NS00040710
    • BAY73-4506
    • Regorafenib (BAY73-4506,Fluoro-Sorafenib)?
    • 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide
    • REGORAFENIB (USP-RS)
    • CHEMBL1946170
    • SR-01000941571-1
    • Regorafenib (BAY73-4506)
    • REGORAFENIB [VANDF]
    • REGORAFENIB (USP MONOGRAPH)
    • Regorafenib crystalline form I
    • SR-01000941571
    • DTXCID8066840
    • SW218097-2
    • DB08896
    • D10138
    • 755037-03-7 , Regorafenib
    • 4-(4-(((4-chloro-3-(trifluoromethyl)phenyl)carbamoyl}amino)-3-fluorophenoxy)-N-methylpyridine-2-carboxamide
    • 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluoro-phenoxy]-N-methyl-pyridine-2-carboxamide
    • Regorafenib [INN]
    • CS-0170
    • DTXCID60148932
    • AB01565826_02
    • EX-A058
    • NCGC00263138-19
    • DTXSID60226441
    • Regorafenib (USAN/INN)
    • MLS006010303
    • BDBM50363397
    • REGORAFENIB [WHO-DD]
    • SB16819
    • Bay-734506
    • AC-25075
    • BAY 73-4506 , Fluoro-Sorafenib
    • Q3891664
    • Stivarga (TN)
    • Regorafenibum
    • BKD17855
    • REGORAFENIB ANHYDROUS
    • 4-[4-({[4-Chloro-3-(trifluoromethy)phenyl]carbamoyl}amino)-3-fluorophenoxy]-1-methylpyridine-2-carboxamide
    • MDL： MFCD16038047
    • Inchi： 1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
    • InChI Key： FNHKPVJBJVTLMP-UHFFFAOYSA-N
    • SMILES： C1(C(NC)=O)=NC=CC(OC2=CC=C(NC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)C(F)=C2)=C1

Computed Properties

  • Exact Mass: 482.07700
  • Monoisotopic Mass: 482.0768807g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 7
  • Heavy Atom Count: 33
  • Rotatable Bond Count: 9
  • Complexity: 686
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 4.2
  • Topological Polar Surface Area: 92.4?2

Experimental Properties

  • Color/Form: No data avaiable
  • Density: 1.5±0.1 g/cm3
  • Melting Point: 206.0 to 210.0 °C
  • Boiling Point: 513.4°C at 760 mmHg
  • Flash Point: 264.3±30.1 °C
  • Solubility: In vitro: DMSO solubility ≥ 260 mg/ml (538.50 mm) * "≥" means soluble, but saturation unknown
  • PSA: 92.35000
  • LogP: 6.22570
  • Vapor Pressure: 0.0±1.3 mmHg at 25°C

Regorafenib Security Information

Regorafenib Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
R127804-25mg
Regorafenib
 755037-03-7 ≥99%
25mg
 ￥369.90 2023-09-01
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
R127804-500mg
Regorafenib
 755037-03-7 ≥99%
500mg
 ￥2969.90 2023-09-01
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
R127804-5mg
Regorafenib
 755037-03-7 ≥99%
5mg
 ￥123.90 2023-09-01
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
R127804-100mg
Regorafenib
 755037-03-7 ≥99%
100mg
 ￥989.90 2023-09-01
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
R127804-10mg
Regorafenib
 755037-03-7 ≥99%
10mg
 ￥219.90 2023-09-01
S e l l e c k ZHONG GUO
S1178-10mM (1mL in DMSO)
Regorafenib
 755037-03-7 99.98%
10mM (1mL in DMSO)
 ￥794.43 2023-09-16
S e l l e c k ZHONG GUO
S1178-5mg
Regorafenib
 755037-03-7 99.98%
5mg
 ￥647.01 2023-09-16
S e l l e c k ZHONG GUO
S1178-25mg
Regorafenib
 755037-03-7 99.98%
25mg
 ￥1941.03 2023-09-16
S e l l e c k ZHONG GUO
S1178-100mg
Regorafenib
 755037-03-7 99.98%
100mg
 ￥4823.91 2023-09-16
SHANG HAI YI EN HUA XUE JI SHU Co., Ltd.
R027002-100mg
Regorafenib
 755037-03-7 99%
100mg
 ￥1188 2024-05-21

Regorafenib Production Method

Regorafenib Suppliers

Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:755037-03-7)Regorafenib
Order Number:sfd7231
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:34
Price ($):discuss personally
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:755037-03-7)Regorafenib
Order Number:LE778;LE26799561
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 11:39
Price ($):discuss personally

Regorafenib Spectrogram

MS-MS
MS-MS
13C NMR
13C NMR
1H NMR 300 MHz DMSO
1H NMR

Regorafenib Related Literature

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755037-03-7 (Regorafenib) Related Products

Recommended suppliers
Suzhou Senfeida Chemical Co., Ltd
(CAS:755037-03-7)Regorafenib
sfd7231
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:755037-03-7)Regorafenib
LE778;LE26799561
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
Email