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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Exploring (3S)-3-amino-3-cyclopropyl-propanoic acid (CAS No. 754176-53-9): A Versatile Chiral Building Block in Modern Chemistry

In the realm of synthetic and medicinal chemistry, (3S)-3-amino-3-cyclopropyl-propanoic acid (CAS No. 754176-53-9) has emerged as a pivotal chiral intermediate. This compound, characterized by its cyclopropyl moiety and amino acid backbone, is increasingly sought after for its role in designing bioactive molecules. Its unique stereochemistry and structural rigidity make it a valuable asset in drug discovery, particularly for targeting G-protein-coupled receptors (GPCRs) and enzyme inhibitors. Researchers are leveraging its chiral purity to enhance the efficacy of peptide-based therapeutics, a trending topic in precision medicine.

The growing interest in small-molecule drugs and bioconjugation techniques has further amplified the demand for (3S)-3-amino-3-cyclopropyl-propanoic acid. Its CAS No. 754176-53-9 is frequently queried in databases like SciFinder and Reaxys, reflecting its industrial relevance. A surge in searches for "chiral synthons for drug development" and "cyclopropyl amino acid derivatives" underscores its alignment with current pharmaceutical trends. Notably, its application in PROTACs (Proteolysis-Targeting Chimeras) and ADC (Antibody-Drug Conjugate) platforms highlights its adaptability to cutting-edge cancer therapeutics.

From a synthetic perspective, the stereoselective synthesis of (3S)-3-amino-3-cyclopropyl-propanoic acid often involves asymmetric hydrogenation or enzymatic resolution, methods widely discussed in green chemistry forums. The compound’s low toxicity profile and compatibility with click chemistry reactions resonate with the industry’s shift toward sustainable methodologies. FAQs such as "How to optimize yield of (3S)-3-amino-3-cyclopropyl-propanoic acid?" or "Applications in peptide mimetics" dominate academic discussions, indicating its interdisciplinary appeal.

Beyond pharmaceuticals, CAS No. 754176-53-9 finds utility in material science, particularly in designing bio-based polymers with enhanced thermal stability. Its carboxylate and amine functionalities enable covalent modifications, a feature exploited in smart materials research. As the demand for biodegradable and high-performance polymers grows, this compound’s role is poised to expand, aligning with global sustainability goals.

In summary, (3S)-3-amino-3-cyclopropyl-propanoic acid (CAS No. 754176-53-9) exemplifies the convergence of chiral synthesis, drug discovery, and green technology. Its multifaceted applications and rising prominence in academic literature and patent filings cement its status as a cornerstone of modern organic chemistry.

• 2225127-06-8((3R)-3-amino-3-cyclopropylpropanoic acid hydrochloride)
• 344587-40-2((3S)-3-amino-3-cyclopropyl-propanoic acid;hydrochloride)
• 1260587-46-9((3R)-3-Amino-3-cyclopropylpropanoic acid)
• 147458-98-8(Cyclopropaneacetic acid, 1-amino-2-methyl-, trans-(+)- (9CI))
• 331633-72-8(3-amino-3-cyclopropyl-propanoic acid)
• 331633-75-1(3-amino-3-cyclopropylpropanoic acid hydrochloride)
• 1270536-24-7(3-Amino-3-cyclopropylbutanoic acid)
• 1995328-16-9(3-Amino-3-(2-methylcyclopropyl)pentanoic acid)
• 1507511-13-8(3-Amino-3-cyclopropylpentanoic acid)
• 2154267-57-7(3-amino-3-{spiro2.2pentan-1-yl}propanoic acid)