• 1. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 2. Acetylcholinesterase amperometric detection system based on a cobalt(II) tetraphenylporphyrin-modified electrode
  Analyst, 1996,121, 1123-1126
• 3. An automated in-chip-catalytic–spectrophotometric method for determination of copper(ii) using a multisyringe flow injection analysis-multipumping flow system?
  Camelia Henríquez,Edwin Palacio,Víctor Cerdà Anal. Methods, 2014,6, 8494-8504
• 4. Alternative mixtures to R-600a. Theoretical assessment and experimental energy evaluation of binary mixtures in a commercial cooler: Mélanges alternatifs au R-600a. évaluation théorique et évaluation énergétique expérimentale de mélanges binaires dans un refroidisseur commercial.
  DanielCalleja-Anta,DanielSánchez,LauraNebot-Andres,RamónCabello,RodrigoLlopis
• 5. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Anisoles

Comprehensive Overview of 1-(4-Methoxyphenoxy)-3-(Piperazin-1-yl)Propan-2-ol (CAS No. 75375-23-4)

1-(4-Methoxyphenoxy)-3-(piperazin-1-yl)propan-2-ol, identified by its CAS number 75375-23-4, is a chemically significant compound with a unique structure combining a piperazine moiety and a methoxyphenoxy group. This compound has garnered attention in pharmaceutical and biochemical research due to its potential applications in drug development. The presence of both piperazine and methoxyphenoxy functionalities makes it a versatile intermediate for synthesizing bioactive molecules. Researchers are particularly interested in its role as a building block for designing compounds targeting neurological and metabolic pathways.

In recent years, the demand for piperazine derivatives like 1-(4-methoxyphenoxy)-3-(piperazin-1-yl)propan-2-ol has surged, driven by their utility in medicinal chemistry. The compound’s CAS no 75375-23-4 is frequently searched in academic and industrial databases, reflecting its relevance in drug discovery. Users often inquire about its synthesis, purity, and applications in high-throughput screening or structure-activity relationship (SAR) studies. Its structural features align with current trends in fragment-based drug design, a hot topic in pharmaceutical research.

The compound’s methoxyphenoxy group contributes to its lipophilicity, which is critical for membrane permeability—a key factor in central nervous system (CNS) drug development. Meanwhile, the piperazine ring enhances solubility and binding affinity to biological targets. These properties make CAS 75375-23-4 a candidate for optimizing pharmacokinetic profiles in preclinical studies. Searches for “piperazine-based drug candidates” or “methoxyphenoxy derivatives in medicine” often lead to discussions about this compound.

From a synthetic perspective, 1-(4-methoxyphenoxy)-3-(piperazin-1-yl)propan-2-ol is typically prepared via nucleophilic substitution reactions, leveraging the reactivity of its propan-2-ol backbone. Researchers emphasize the importance of controlling stereochemistry, as enantiomeric purity can significantly impact biological activity. Queries like “synthesis of piperazine-propanol derivatives” or “chiral resolution of CAS 75375-23-4” highlight these technical considerations.

Beyond pharmaceuticals, this compound’s dual-functional nature sparks interest in material science, particularly in designing smart polymers or chelating agents. Its ability to form stable complexes with metals is explored in catalysis and environmental chemistry. The keyword “piperazine in green chemistry” resonates with these applications, aligning with the global push for sustainable research practices.

Quality control and analytical methods for 75375-23-4 are also frequently discussed. High-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) are standard techniques for characterizing its purity. Search trends like “HPLC analysis of piperazine compounds” reflect the need for reliable quantification protocols in industrial settings.

In summary, 1-(4-methoxyphenoxy)-3-(piperazin-1-yl)propan-2-ol (CAS no 75375-23-4) bridges multiple disciplines, from drug discovery to materials engineering. Its structural versatility and bioactive potential ensure its continued prominence in scientific literature. As researchers explore novel applications, this compound remains a focal point for innovation, answering pressing questions in modern chemistry and biomedicine.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)