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  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Boc-D-2-Aminosuberic Acid: A Comprehensive Overview

Boc-D-2-Aminosuberic Acid (CAS No. 75113-71-2) is a compound of significant interest in the fields of organic chemistry, biochemistry, and pharmacology. This compound, also known as tert-butoxycarbonyl-D-2-amino adipic acid, is a derivative of 2-amino adipic acid with a tert-butoxycarbonyl (Boc) protecting group. The Boc group is widely used in peptide synthesis to protect the amino group during the synthesis process, ensuring precise control over the reaction steps.

The molecular formula of Boc-D-2-Aminosuberic Acid is C10H19NO5, and its molecular weight is 219.25 g/mol. The compound exists as a white crystalline powder and is soluble in common organic solvents such as dichloromethane and dimethylformamide. Its physical properties make it suitable for various synthetic applications, particularly in the preparation of peptides and other bioactive molecules.

Recent studies have highlighted the importance of Boc-D-2-Aminosuberic Acid in peptide synthesis, where it serves as a key intermediate. The use of the Boc protecting group allows for efficient synthesis of complex peptides with high purity and yield. Researchers have also explored the application of this compound in drug delivery systems, where its biocompatibility and controlled release properties are advantageous.

In addition to its role in peptide synthesis, Boc-D-2-Aminosuberic Acid has been investigated for its potential in materials science. Its structure makes it a candidate for the development of novel polymers and biomaterials with tailored properties. For instance, studies have shown that derivatives of this compound can be used to create biodegradable polymers for medical applications such as drug delivery and tissue engineering.

The synthesis of Boc-D-2-Aminosuberic Acid typically involves a multi-step process starting from adipic acid. The introduction of the Boc group is achieved through a reaction with di-tert-butyl dicarbonate (Boc anhydride) in the presence of a base such as pyridine or triethylamine. This step ensures that the amino group is effectively protected while maintaining the integrity of the carboxylic acid groups.

One of the most promising areas of research involving Boc-D-2-Aminosuberic Acid is its application in drug development. Scientists have explored its use as a building block for constructing bioactive peptides with potential therapeutic applications. For example, recent studies have demonstrated that peptides derived from this compound exhibit potent anti-inflammatory and antimicrobial activities, making them candidates for novel drug therapies.

Furthermore, Boc-D-2-Aminosuberic Acid has been utilized in chiral recognition studies due to its D configuration. Chiral compounds like this are essential in asymmetric synthesis, where they enable the production of enantiomerically pure compounds with specific biological activities. This property has made it a valuable tool in medicinal chemistry for developing drugs with high efficacy and reduced side effects.

In terms of safety and handling, Boc-D-2-Aminosuberic Acid is generally considered non-hazardous under normal conditions. However, it should be stored in a cool, dry place away from light to prevent degradation. Proper personal protective equipment should be used during handling to minimize exposure risks.

Looking ahead, ongoing research aims to expand the applications of Boc-D-2-Aminosuberic Acid further into areas such as nanotechnology and green chemistry. Its unique structure and functional groups make it a versatile building block for creating advanced materials with unprecedented properties.

In conclusion, Boc-D-2-Aminosuberic Acid (CAS No. 75113-71-2) is a versatile compound with significant potential in various scientific disciplines. Its role as a key intermediate in peptide synthesis, combined with its promising applications in drug development and materials science, underscores its importance in modern chemical research.

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• 106719-44-2(Boc-D-Lys-OH)
• 129850-62-0((R,S)-Boc-2-amino-tetradecanoic acid)
• 21887-64-9(Nα-Boc-L-Ornithine)
• 13734-28-6(Boc-Lys-OH)
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• 115573-33-6(N-tert-Butoxycarbonyl-L-ALPHA-aminosuberic acid)