Cas no 74427-22-8 (2,2-Difluoroethyl Triflate)

2,2-Difluoroethyl Triflate is a highly reactive alkylating agent commonly employed in organic synthesis and fluorination reactions. Its key advantages include its strong electrophilic character, making it effective for introducing the 2,2-difluoroethyl group into various substrates. The triflate leaving group enhances reactivity, enabling efficient transformations under mild conditions. This compound is particularly useful in pharmaceutical and agrochemical research, where precise fluorination is critical for modulating biological activity and metabolic stability. Its stability under controlled conditions and compatibility with a range of solvents further contribute to its utility in synthetic applications. Proper handling is essential due to its moisture sensitivity and potential reactivity.
2,2-Difluoroethyl Triflate structure
2,2-Difluoroethyl Triflate structure
Product Name:2,2-Difluoroethyl Triflate
CAS No:74427-22-8
MF:C3H3F5O3S
MW:214.111137628555
MDL:MFCD02093342
CID:556498
PubChem ID:354334252
Update Time:2025-05-28

2,2-Difluoroethyl Triflate Chemical and Physical Properties

Names and Identifiers

    • Methanesulfonic acid,1,1,1-trifluoro-, 2,2-difluoroethyl ester
    • 2,2-Difluoroethyltrifluoromethanesulphonate
    • 2,2-Difluoroethyl Trifluoromethanesulfonate
    • 2,2-Difluoroethyl Triflate
    • 2,2-difluoroethyl trifluoromethane-sulfonate
    • PC3793
    • trifluoromethanesulfonic acid 2,2-difluoroethyl ester
    • 2,2-difluoroethyltrifluoromethanesulfonate
    • Methanesulfonic acid, trifluoro-, 2,2-difluoroethyl ester
    • difluorethyltriflate
    • difluoroethyl triflate
    • C3H3F5O3S
    • NKULBUOBGILEAR-UHFFFAOYSA-N
    • SBB094915
    • KM16
    • AS-49472
    • EN300-65366
    • 2,2-difluoroethyl trifluoromethanesulphonate
    • AMY6663
    • AKOS005762882
    • I10778
    • trifluoromethanesulfonate (2,2-difluoroethyl) ester
    • 74427-22-8
    • SCHEMBL145453
    • CS-W023132
    • A838128
    • FT-0676375
    • DTXSID30378880
    • trifluoro-methanesulfonic acid 2,2-difluoro-ethyl ester
    • SY035998
    • trifluoromethanesulfonate (2,2-difluoroethyl)ester
    • MFCD02093342
    • 2, 2-difluoroethyl trifluoromethanesulfonate
    • D5299
    • difluoroethyl trifluoromethane-sulfonate
    • PB43394
    • 2,2-difluoroethyl trifluoromethansulfonate
    • 2,2-difluoroethyl trifluoromethane sulfonate
    • MDL： MFCD02093342
    • Inchi： 1S/C3H3F5O3S/c4-2(5)1-11-12(9,10)3(6,7)8/h2H,1H2
    • InChI Key： NKULBUOBGILEAR-UHFFFAOYSA-N
    • SMILES： S(C(F)(F)F)(=O)(=O)OCC(F)F

Computed Properties

  • Exact Mass: 213.97200
  • Monoisotopic Mass: 213.97230594g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 8
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 3
  • Complexity: 223
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 51.8
  • XLogP3: 1.7

Experimental Properties

  • Color/Form: No data available
  • Density: 1.608±0.06 g/cm3 (20 oC 760 Torr),
  • Melting Point: No data available
  • Boiling Point: 118°C(lit.)
  • Flash Point: 32.1±27.3 oC,
  • Refractive Index: 1.3300-1.3340
  • Solubility: Slightly soluble (1.3 g/l) (25 o C),
  • PSA: 51.75000
  • LogP: 2.19850

2,2-Difluoroethyl Triflate Security Information

2,2-Difluoroethyl Triflate Customs Data

  • HS CODE：2905590090
  • Customs Data：

    China Customs Code:

    2905590090

    Overview:

    2905590090 Halogenation of other acyclic alcohols\Sulfonated and other derivatives.Regulatory conditions:nothing.VAT:17.0%.Tax refund rate:9.0%.MFN tariff:5.5%.general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, packing

    Summary:

    2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols.Supervision conditions:None.VAT:17.0%.Tax rebate rate:9.0%.MFN tariff:5.5%.General tariff:30.0%

2,2-Difluoroethyl Triflate Pricemore >>

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2,2-Difluoroethyl Triflate Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:74427-22-8)2,2-二氟乙基三氟甲烷磺酸鹽
Order Number:LE26827300
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:59
Price ($):discuss personally

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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:74427-22-8)2,2-二氟乙基三氟甲烷磺酸鹽
LE26827300
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry
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