Cas no 74370-93-7 (4-tert-butyl-1,3-thiazol-2-amine)

4-tert-Butyl-1,3-thiazol-2-amine is a specialized organic compound featuring a thiazole core substituted with a tert-butyl group at the 4-position and an amine at the 2-position. This structure imparts unique steric and electronic properties, making it valuable as a building block in pharmaceutical and agrochemical synthesis. The tert-butyl group enhances lipophilicity and stability, while the amine functionality offers reactivity for further derivatization. Its well-defined molecular architecture is advantageous for designing bioactive molecules, particularly in heterocyclic chemistry. The compound is typically characterized by high purity and consistent performance, ensuring reliability in research and industrial applications.
4-tert-butyl-1,3-thiazol-2-amine structure
74370-93-7 structure
Product Name:4-tert-butyl-1,3-thiazol-2-amine
CAS No:74370-93-7
MF:C7H12N2S
MW:156.248579978943
MDL:MFCD00051644
CID:90632
PubChem ID:2734202
Update Time:2025-10-11

4-tert-butyl-1,3-thiazol-2-amine Chemical and Physical Properties

Names and Identifiers

    • 4-(tert-Butyl)thiazol-2-amine
    • 2-Amino-4-tert-butylthiazole
    • 4-(tert-Butyl)-1,3-thiazol-2-amine
    • 4-tert-butyl-1,3-thiazol-2-amine
    • 4-tert-Butyl-thiazol-2-ylamine
    • C7H12N2S
    • 4-tert-Butyl-1,3-thiazol-2-ylamine
    • 4-tert-Butyl-2-aminothiazole
    • 2-Amino-4-(2-methyl-2-propyl)thiazole
    • 2-Amino-4-tertbutylthiazole
    • CHEBI:195133
    • 74370-93-7
    • 2-Amino-4-[(1,1-dimethyl)ethyl]thiazole
    • AKOS000268275
    • MFCD00051644
    • DTXSID00370159
    • F0193-0249
    • AM804306
    • SCHEMBL77483
    • 2-amino-4-t-butylthiazole
    • CS-0037875
    • CCG-46729
    • [3-(2-Chlorophenyl)isoxazol-5-yl]methylamine
    • SY014226
    • 4-(1,1-dimethyl-ethyl)-2-thiazolamine
    • FT-0611273
    • CHEMBL4778010
    • 4-tert-butylthiazol-2-amine
    • BB 0217952
    • AB-601/30963031
    • 4-tert-Butylthiazol-2-ylamine
    • Maybridge1_003081
    • HMS550E01
    • EN300-247381
    • 2-amino-4-[(1,1-dimethyl)-ethyl]thiazole
    • SR-01000636406-1
    • Z56799661
    • EN300-02532
    • 2-Thiazolamine, 4-(1,1-dimethylethyl)-
    • BDBM626117
    • BS-22839
    • A838106
    • STK397304
    • DB-055869
    • ALBB-001557
    • MDL： MFCD00051644
    • Inchi： 1S/C7H12N2S/c1-7(2,3)5-4-10-6(8)9-5/h4H,1-3H3,(H2,8,9)
    • InChI Key： CUWZBHVYLVGOAB-UHFFFAOYSA-N
    • SMILES： S1C(N)=NC(=C1)C(C)(C)C
    • BRN： 114270

Computed Properties

  • Exact Mass: 156.07200
  • Monoisotopic Mass: 156.072
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 1
  • Complexity: 119
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: 2.3
  • Topological Polar Surface Area: 67.2A^2

Experimental Properties

  • Color/Form: Lens powder.
  • Density: 1.107±0.06 g/cm3 (20 oC 760 Torr),
  • Melting Point: 100-101 oC
  • Boiling Point: 141-143 oC (20 Torr)
  • Flash Point: 106.9±18.7 oC,
  • Refractive Index: 1.6000 (estimate)
  • Solubility: Slightly soluble (1.3 g/l) (25 o C),
  • PSA: 67.15000
  • LogP: 2.60400
  • Solubility: Not determined

4-tert-butyl-1,3-thiazol-2-amine Security Information

4-tert-butyl-1,3-thiazol-2-amine Customs Data

  • HS CODE：2934100090
  • Customs Data：

    China Customs Code:

    2934100090

    Overview:

    2934100090. Compounds that structurally contain a non fused thiazole ring(Whether hydrogenated or not). VAT:17.0%. Tax refund rate:9.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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4-tert-butyl-1,3-thiazol-2-amine Production Method

4-tert-butyl-1,3-thiazol-2-amine Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:74370-93-7)2-氨基-4-叔丁基噻唑
Order Number:LE5868958
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:45
Price ($):discuss personally

4-tert-butyl-1,3-thiazol-2-amine Related Literature

Additional information on 4-tert-butyl-1,3-thiazol-2-amine

Comprehensive Overview of 4-tert-butyl-1,3-thiazol-2-amine (CAS No. 74370-93-7): Properties, Applications, and Industry Insights

4-tert-butyl-1,3-thiazol-2-amine (CAS No. 74370-93-7) is a specialized organic compound belonging to the thiazole family, a heterocyclic structure featuring sulfur and nitrogen atoms. This compound has garnered significant attention in pharmaceutical and agrochemical research due to its unique molecular framework, which enables versatile chemical modifications. The presence of a tert-butyl group at the 4-position enhances steric stability, while the amine functionality at the 2-position offers reactivity for further derivatization. Researchers frequently explore its role as a building block in drug discovery, particularly for antimicrobial and anti-inflammatory agents.

In recent years, the demand for thiazole derivatives like 4-tert-butyl-1,3-thiazol-2-amine has surged, driven by trends in green chemistry and sustainable synthesis. A 2023 study highlighted its potential as an intermediate in catalysis and material science, aligning with the global push for eco-friendly industrial processes. Users often search for "thiazole amine solubility" or "74370-93-7 synthesis method," reflecting practical concerns in laboratory applications. The compound’s lipophilicity, influenced by the tert-butyl moiety, makes it valuable for optimizing drug bioavailability—a hot topic in medicinal chemistry forums.

From a technical perspective, CAS 74370-93-7 exhibits a melting point range of 110–115°C and moderate solubility in polar organic solvents, as documented in Reaxys and SciFinder databases. Its IR spectrum typically shows characteristic N-H stretches near 3300 cm?1, while NMR data reveals distinct peaks for the thiazole ring protons between 6.5–7.5 ppm. These properties are critical for quality control in custom synthesis services, another high-traffic keyword in chemical procurement platforms.

Innovative applications of 4-tert-butyl-1,3-thiazol-2-amine extend to electronic materials, where its electron-rich structure aids in designing organic semiconductors. This aligns with booming interest in flexible electronics and OLED technology. Notably, patent analyses reveal its use in photovoltaic additives, addressing frequent queries about "thiazoles in solar cells." Such interdisciplinary relevance underscores its importance beyond traditional chemistry sectors.

Regulatory and safety profiles of 74370-93-7 are frequently searched in SDS documentation. While not classified as hazardous under major chemical inventories, proper handling with PPE is recommended due to potential dust irritation. The compound’s stability under ambient conditions makes it suitable for long-term storage, a practical advantage for industrial buyers. Suppliers often highlight its high purity grades (>98%) to meet GMP standards—a key concern for pharmaceutical intermediates procurement.

Future prospects for 4-tert-butyl-1,3-thiazol-2-amine include emerging roles in bioconjugation techniques and proteomics, where its amine group enables crosslinking with biomolecules. As AI-driven drug design accelerates, this compound’s QSAR parameters are being modeled to predict novel bioactivities—addressing trending searches like "machine learning in heterocyclic chemistry." Collaborative studies between academia and industry continue to expand its utility, ensuring its prominence in high-value chemical markets.

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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:74370-93-7)2-氨基-4-叔丁基噻唑
LE5868958
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry
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