• 1. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
  Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023
• 2. Alternative mixtures to R-600a. Theoretical assessment and experimental energy evaluation of binary mixtures in a commercial cooler: Mélanges alternatifs au R-600a. évaluation théorique et évaluation énergétique expérimentale de mélanges binaires dans un refroidisseur commercial.
  DanielCalleja-Anta,DanielSánchez,LauraNebot-Andres,RamónCabello,RodrigoLlopis
• 3. An Assessment of the Laminar Hypersonic Double-Cone Experiments in the LENS-XX Tunnel
  JaideepRay,PatrickBlonigan,EricT.Phipps,KathrynMaupin
• 4. Aggregation-induced chiral symmetry breaking of a naphthalimide–cyanostilbene dyad?
  Xin Li,Liangliang Zhu,Sai Duan,Yanli Zhao,Hans ?gren Phys. Chem. Chem. Phys., 2014,16, 23854-23860
• 5. Aggregation-induced emission enhancement upon Al3+ complexation with a tetrasulfonated calix[4]bisazacrown fluorescent molecular sensor?
  Yi-Bin Ruan,Alexis Depauw,Isabelle Leray Org. Biomol. Chem., 2014,12, 4335-4341

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzopyrazoles Indazoles

3-Bromo-7-nitroindazole (CAS No. 74209-34-0): A Versatile Heterocyclic Compound for Pharmaceutical and Research Applications

3-Bromo-7-nitroindazole (CAS No. 74209-34-0) is a highly valuable heterocyclic compound that has gained significant attention in recent years due to its unique chemical properties and broad range of applications. This nitro-substituted indazole derivative serves as a crucial building block in medicinal chemistry, particularly in the development of novel pharmaceutical intermediates and biologically active compounds. The presence of both bromo and nitro functional groups at the 3- and 7-positions respectively makes this compound an excellent candidate for various cross-coupling reactions and nucleophilic substitution reactions.

The growing interest in 3-Bromo-7-nitroindazole synthesis and applications reflects current trends in drug discovery, where researchers are increasingly focusing on nitrogen-containing heterocycles as privileged scaffolds. Recent searches in scientific databases and AI platforms reveal frequent queries about "indazole derivatives in drug development", "bromo-nitro indazole applications", and "CAS 74209-34-0 suppliers", indicating strong market demand for this specialty chemical. The compound's molecular structure offers excellent potential for creating kinase inhibitors, anti-inflammatory agents, and other therapeutic molecules, aligning with the pharmaceutical industry's focus on targeted therapies.

From a chemical perspective, 3-Bromo-7-nitroindazole exhibits interesting physical and chemical characteristics. The compound typically appears as a yellow to orange crystalline powder with good stability under standard storage conditions. Its molecular weight of 242.02 g/mol and precise substitution pattern make it particularly useful for structure-activity relationship studies in medicinal chemistry programs. The bromo substituent at the 3-position serves as an excellent handle for palladium-catalyzed coupling reactions, while the nitro group at the 7-position can be readily reduced to an amino group for further derivatization.

The applications of 3-Bromo-7-nitroindazole extend across multiple scientific disciplines. In pharmaceutical research, it serves as a key intermediate for developing protein kinase inhibitors, particularly those targeting cancer pathways and inflammatory diseases. The compound's structural features make it valuable for creating selective enzyme inhibitors, with recent studies exploring its potential in neurodegenerative disease research. Additionally, material scientists have investigated its use in creating functionalized organic materials with unique electronic properties.

Quality control and analytical characterization of 3-Bromo-7-nitroindazole typically involve advanced techniques such as HPLC purity analysis, mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy. Reputable suppliers provide comprehensive certificates of analysis to ensure the compound meets rigorous purity standards, often exceeding 98% purity for research applications. Proper handling requires standard laboratory safety precautions, including the use of personal protective equipment and adequate ventilation, though the compound is not classified under stringent regulatory categories.

The market for 3-Bromo-7-nitroindazole has shown steady growth, driven by increasing R&D investments in small molecule therapeutics and drug discovery platforms. Current trends indicate particular demand from contract research organizations (CROs) and academic institutions engaged in medicinal chemistry projects. The compound's versatility has also led to exploration in agrochemical research and material science applications, creating additional market opportunities. Suppliers typically offer the compound in various packaging options, from milligram quantities for initial screening to kilogram scales for process development.

Recent scientific literature highlights innovative uses of 3-Bromo-7-nitroindazole in combinatorial chemistry and high-throughput screening approaches. Its structural features make it particularly valuable for creating diverse chemical libraries through parallel synthesis techniques. Researchers have also explored its potential as a precursor for fluorescent probes and biochemical tools, capitalizing on the indazole core's favorable photophysical properties. These applications align with current interests in chemical biology and diagnostic agent development.

For researchers considering 3-Bromo-7-nitroindazole purchase, several factors should be evaluated. The compound's synthetic route, purity specifications, and supplier reliability are critical considerations. Many investigators seek information about "74209-34-0 price comparison" and "bulk 3-Bromo-7-nitroindazole suppliers", reflecting practical concerns in procurement. Storage recommendations typically suggest keeping the compound in a cool, dry environment, protected from light to maintain stability over extended periods.

Future perspectives for 3-Bromo-7-nitroindazole appear promising, with ongoing research exploring novel applications in personalized medicine and targeted drug delivery systems. The compound's structural versatility positions it well for emerging areas such as proteolysis targeting chimeras (PROTACs) and covalent inhibitor design. As the pharmaceutical industry continues to prioritize structure-based drug design, the demand for well-characterized building blocks like 3-Bromo-7-nitroindazole is expected to grow substantially in the coming years.

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• 67400-25-3(3-Bromo-5-nitro-1H-indazole)
• 70315-68-3(3-bromo-6-nitro-1H-indazole)
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