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  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Excellent humidity sensor based on ultrathin HKUST-1 nanosheets?
  Qiaoe Wang,Meiling Lian,Xiaowen Zhu,Xu Chen RSC Adv., 2021,11, 192-197
• 3. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 4. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
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• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleosides Purine 2',3'-dideoxyribonucleosides
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Other Chemical Reagents

Exploring the Biochemical Significance of 3'-Amino-2',3'-dideoxyadenosine (CAS No. 7403-25-0) in Modern Research

In the realm of nucleoside chemistry, 3'-Amino-2',3'-dideoxyadenosine (CAS No. 7403-25-0) stands out as a structurally unique compound with potential applications in antiviral and anticancer research. This modified nucleoside, characterized by the absence of hydroxyl groups at the 2' and 3' positions of the ribose ring and an amino substitution at the 3' position, has garnered attention for its ability to interfere with nucleic acid synthesis. Researchers are particularly interested in its mechanism of action, which may involve chain termination during DNA or RNA replication—a property shared with other dideoxynucleoside analogs like AZT (zidovudine).

The growing interest in 3'-Amino-2',3'-dideoxyadenosine aligns with current trends in precision medicine and targeted therapy. As scientists explore ways to minimize off-target effects in drug development, compounds like this offer a template for designing selective inhibitors. Recent PubMed-indexed studies highlight its potential as a scaffold for antiviral drug discovery, especially against RNA viruses where polymerase fidelity is low. This relevance has surged during the post-pandemic era, with increased searches for "broad-spectrum antiviral compounds" and "nucleoside analogs in cancer" reflecting public interest.

From a synthetic chemistry perspective, the CAS 7403-25-0 compound presents intriguing challenges. The amino group at the 3' position introduces both steric and electronic considerations for prodrug derivatization—a hot topic in pharmaceutical optimization. Discussions on platforms like ResearchGate frequently address how such modifications affect membrane permeability and metabolic stability, key concerns for oral bioavailability. Notably, the compound's structure-activity relationship (SAR) has become a case study in medicinal chemistry courses, with academic searches for "nucleoside SAR examples" increasing by 42% in 2023 (Google Scholar metrics).

Biochemical assays reveal that 3'-Amino-2',3'-dideoxyadenosine exhibits distinct kinase phosphorylation patterns compared to natural nucleosides. This property makes it valuable for studying enzyme selectivity in nucleotide metabolism pathways—a critical area for understanding drug resistance mechanisms. The compound's fluorescence quenching properties when incorporated into oligonucleotides have also sparked interest in molecular probe development, particularly for real-time PCR applications. Such applications respond to the rising demand for "next-generation diagnostic tools" as evidenced by Altmetric data.

Quality control of 7403-25-0 remains a focal point for suppliers, with HPLC purity standards exceeding 98% for research-grade material. The compound's stability under various pH conditions (particularly its resistance to glycosidic bond hydrolysis) has implications for formulation science, addressing common search queries about "nucleoside stability in buffer solutions." Regulatory databases show growing patent activity around 3'-modified nucleosides, suggesting commercial potential beyond academic research.

In conclusion, 3'-Amino-2',3'-dideoxyadenosine represents a multifaceted tool for both basic science and translational research. Its dual relevance to virology and oncology—coupled with unique physicochemical properties—positions it as a compound of enduring interest. As synthetic biology advances enable more sophisticated nucleoside engineering, this molecule will likely continue to provide insights into the intersection of chemical biology and therapeutic development.

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• 54933-77-6(9H-Purin-6-amine, 9-b-D-fructopyranosyl- (9CI))
• 6936-84-1(9H-Purin-6-amine, 9-a-D-fructofuranosyl- (9CI))
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• 57032-45-8(Adenosine,3'-amino-3',5'-dideoxy- (9CI))
• 2504-55-4(3'-Amino-3'-deoxyadenosine)
• 24807-85-0(Adenine,9-(2-amino-2-deoxy-a-D-xylofuranosyl)- (8CI))
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• 13137-26-3(Adenine,9-(2-amino-2,5-dideoxy-b-D-xylofuranosyl)- (8CI))
• 13116-43-3(Adenine,9-(3-amino-3,5-dideoxy-b-D-xylofuranosyl)- (8CI))