• 1. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 3. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 4. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 5. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Tyrosine and derivatives

Comprehensive Overview of 3-Formyl-L-Tyrosine (CAS No. 739308-18-0): Properties, Applications, and Research Insights

3-Formyl-L-Tyrosine (CAS No. 739308-18-0) is a chemically modified derivative of the naturally occurring amino acid L-tyrosine. This compound has garnered significant attention in biochemical and pharmaceutical research due to its unique aldehyde functional group, which enables diverse applications in protein conjugation, biomarker development, and drug discovery. With the rise of precision medicine and bioconjugation technologies, researchers are increasingly exploring its potential in targeted therapies and diagnostic tools.

The molecular structure of 3-formyl-L-tyrosine features a formyl group (-CHO) attached to the aromatic ring of L-tyrosine, making it a versatile intermediate for click chemistry and site-specific labeling. This modification is particularly valuable in antibody-drug conjugates (ADCs), where controlled payload attachment is critical for efficacy. Recent studies highlight its role in proteomics and enzyme engineering, addressing common challenges like post-translational modification analysis.

In the context of sustainable chemistry, 3-formyl-L-tyrosine aligns with the growing demand for green synthesis methods. Researchers are optimizing its production using enzymatic catalysis to reduce waste and energy consumption. This approach resonates with the life sciences industry, where eco-friendly reagents are prioritized. Additionally, its compatibility with aqueous reaction conditions makes it suitable for biocompatible materials design.

From a market perspective, the demand for custom amino acid derivatives like 3-formyl-L-tyrosine is driven by advancements in peptide therapeutics and nanotechnology. Companies specializing in high-purity biochemicals are expanding their portfolios to include such compounds, catering to academic labs and biotech startups. Analytical techniques such as HPLC and mass spectrometry ensure stringent quality control, meeting the needs of GMP-compliant applications.

Emerging trends in cancer research have further spotlighted 3-formyl-L-tyrosine. Its ability to facilitate controlled drug release in tumor microenvironments is under investigation, with promising results in in vivo models. This aligns with frequent search queries like "amino acid-based drug delivery" and "non-toxic bioconjugation methods", reflecting broader interest in translational science.

For laboratory protocols, handling 3-formyl-L-tyrosine requires attention to pH stability and storage conditions (typically at -20°C under inert atmosphere). Its solubility in polar solvents like water or DMSO simplifies experimental workflows, though kinetic studies recommend optimizing reaction times to maximize yield. These practical insights address common questions such as "how to modify tyrosine residues" and "best practices for aldehyde-reactive probes".

In summary, 3-formyl-L-tyrosine (CAS No. 739308-18-0) represents a critical tool at the intersection of chemical biology and therapeutic innovation. Its dual role as a synthetic building block and biological probe ensures continued relevance in both basic research and industrial applications. As the scientific community seeks multifunctional reagents, this compound exemplifies how molecular design can bridge gaps between discovery and implementation.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)