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Comprehensive Overview of 2-Cyclopropylpyrimidin-5-ol (CAS No. 73901-41-4): Properties, Applications, and Industry Insights

2-Cyclopropylpyrimidin-5-ol (CAS No. 73901-41-4) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research due to its unique structural features. This pyrimidine derivative is characterized by a cyclopropyl substituent at the 2-position and a hydroxyl group at the 5-position, which contribute to its reactivity and potential applications. Researchers and industry professionals frequently search for terms like "2-Cyclopropylpyrimidin-5-ol synthesis", "CAS 73901-41-4 applications", and "pyrimidine-based bioactive compounds", reflecting its relevance in modern chemical development.

The compound’s molecular framework aligns with current trends in fragment-based drug design (FBDD) and scaffold hopping, two hot topics in medicinal chemistry. Its cyclopropyl group enhances metabolic stability, a feature highly sought after in the development of kinase inhibitors and antiviral agents. Recent literature highlights its utility as a building block for small-molecule therapeutics, particularly in oncology and infectious disease research. Queries such as "2-Cyclopropylpyrimidin-5-ol solubility" and "SAR studies of pyrimidine derivatives" underscore its practical importance in lab settings.

From a synthetic perspective, 73901-41-4 is often prepared via Pd-catalyzed cross-coupling reactions or cyclocondensation of β-diketones with amidines. Its logP value and hydrogen-bonding capacity make it a candidate for optimizing drug-like properties, a focal point in AI-driven drug discovery platforms. Notably, its structural motif appears in patents targeting EGFR inhibitors and ROS1 kinase modulators, addressing the growing demand for precision medicine solutions.

In agrochemical applications, 2-Cyclopropylpyrimidin-5-ol serves as a precursor for herbicides and fungicides, leveraging its ability to disrupt plant pathogenic enzymes. Searches for "pyrimidine-based agrochemicals" and "eco-friendly crop protection" correlate with its role in sustainable agriculture innovations. Regulatory agencies have evaluated its derivatives for environmental safety, a critical consideration given the emphasis on green chemistry principles.

Analytical methods for characterizing CAS 73901-41-4 typically involve HPLC-MS and NMR spectroscopy, with researchers frequently inquiring about "spectral data of 2-Cyclopropylpyrimidin-5-ol". The compound’s melting point (reported between 160–165°C) and stability under acidic conditions are key parameters for process chemists. Recent advancements in continuous flow chemistry have streamlined its production, aligning with industry 4.0 automation trends.

Market analysts project growth for pyrimidine intermediates, driven by demand in orphan drug development and bioconjugation techniques. As a research chemical, 73901-41-4 is available through specialty suppliers with strict quality control, often accompanied by COA documentation—a detail frequently searched by procurement specialists. Its compatibility with click chemistry protocols further expands its utility in biopharmaceutical engineering.

Future directions for 2-Cyclopropylpyrimidin-5-ol may include exploration in proteolysis-targeting chimeras (PROTACs) and covalent inhibitor design, areas dominating recent scientific discourse. The compound’s structure-activity relationship (SAR) profile continues to inspire publications in journals like Journal of Medicinal Chemistry, with particular interest in its isosteric replacement potential for quinazoline systems.

• 90339-11-0(2-Ethylpyrimidin-5-ol)
• 132259-91-7(2-Pyrimidineethanol, 5-hydroxy--beta-,-beta--dimethyl- (9CI))
• 85929-96-0(2-tert-Butylpyrimidin-5-ol)
• 78104-95-7(5-Pyrimidinol,2-(1-methylcyclopropyl)-)
• 146237-62-9(5-Pyrimidinol,2-(1,1-dimethylethyl)-, sodium salt (1:1))
• 58173-74-3(2-cyclopropylpyrimidine)
• 103660-24-8(5-Pyrimidinol,2-propyl-)
• 66739-84-2(2-Isopropylpyrimidin-5-ol)
• 78104-97-9(5-Pyrimidinol,2-(cyclopropylmethyl)-)
• 85929-95-9(PYRIMIDINE, 2-(1,1-DIMETHYLETHYL)-5-METHOXY-)