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• 2. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
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• 3. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
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• 4. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
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• 5. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidazopyrimidines Purines and purine derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Other Chemical Reagents

Introduction to 6-Chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (CAS No. 7306-68-5)

6-Chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine, with the CAS number 7306-68-5, is a synthetic purine derivative that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is notable for its unique structural features and potential biological activities, making it a valuable candidate for various therapeutic applications.

The chemical structure of 6-Chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine is characterized by a purine core with a chlorine substituent at the 6-position and a tetrahydro-2H-pyran ring attached at the 9-position. The presence of these functional groups imparts specific properties to the molecule, such as enhanced solubility and stability, which are crucial for its pharmacological evaluation.

Recent studies have explored the potential of 6-Chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine in various biological contexts. One notable area of research is its activity as an adenosine receptor antagonist. Adenosine receptors play a pivotal role in modulating physiological processes such as sleep, pain perception, and immune responses. By selectively blocking these receptors, 6-Chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine has shown promise in treating conditions like insomnia and chronic pain.

In addition to its adenosine receptor antagonistic properties, 6-Chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine has been investigated for its anti-inflammatory effects. Inflammation is a key factor in many diseases, including arthritis and inflammatory bowel disease. Preclinical studies have demonstrated that this compound can inhibit the production of pro-inflammatory cytokines, thereby reducing inflammation and associated symptoms.

The pharmacokinetic profile of 6-Chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine has also been studied extensively. Research indicates that it exhibits favorable absorption, distribution, metabolism, and excretion (ADME) properties, which are essential for its development as a therapeutic agent. The compound's high oral bioavailability and low toxicity make it an attractive candidate for further clinical evaluation.

Clinical trials are currently underway to assess the safety and efficacy of 6-Chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine in human subjects. Preliminary results from phase I trials have shown that the compound is well-tolerated at therapeutic doses, with no significant adverse effects reported. These findings provide a strong foundation for advancing to phase II trials, where the compound's therapeutic potential will be further evaluated in larger patient populations.

Beyond its direct therapeutic applications, 6-Chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine has also been explored as a tool compound in drug discovery and development. Its unique structure and biological activities make it an excellent starting point for designing more potent and selective analogs. Researchers are actively working on optimizing the chemical structure of this compound to enhance its pharmacological properties and reduce potential side effects.

In conclusion, 6-Chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (CAS No. 7306-68-5) represents a promising molecule with diverse biological activities and therapeutic potential. Ongoing research continues to uncover new insights into its mechanisms of action and clinical applications, positioning it as a valuable asset in the field of medicinal chemistry and pharmaceutical research.

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