• 1. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 2. Distinct roles of SNARE-mimicking lipopeptides during initial steps of membrane fusion?
  Alena Koukalová,?árka Pokorná,Aimee L. Boyle,Nestor Lopez Mora,Alexander Kros,Martin Hof,Radek ?achl Nanoscale, 2018,10, 19064-19073
• 3. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
• 4. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 5. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidolactams Imidolactams
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Imidolactams

Comprehensive Overview of 3,5-Diamino-1-ethyl-1H-pyrazole-4-carbonitrile (CAS No. 72943-61-4)

3,5-Diamino-1-ethyl-1H-pyrazole-4-carbonitrile (CAS No. 72943-61-4) is a specialized organic compound that has garnered significant attention in the fields of pharmaceutical research, agrochemical development, and material science. This heterocyclic compound, featuring a pyrazole core, is characterized by its unique structural properties, which make it a valuable intermediate in synthetic chemistry. The presence of both amino and cyano functional groups enhances its reactivity, enabling diverse applications in drug discovery and fine chemical synthesis.

In recent years, the demand for 3,5-diamino-1-ethyl-1H-pyrazole-4-carbonitrile has surged due to its potential role in the development of novel therapeutic agents. Researchers are particularly interested in its utility as a building block for small molecule inhibitors and kinase-targeted drugs, which are pivotal in treating diseases such as cancer and inflammatory disorders. Its nitrogen-rich structure also aligns with the growing trend of designing bioactive heterocycles, a hot topic in medicinal chemistry.

From an industrial perspective, this compound is often utilized in the synthesis of high-performance dyes and photostable pigments, addressing the need for sustainable and eco-friendly alternatives in the textile and coating industries. Its thermal stability and solubility profile make it a preferred choice for formulations requiring precise chemical modifications. Additionally, its relevance in crop protection chemicals has been explored, particularly in the design of herbicides and pesticides with reduced environmental impact.

The synthesis of 3,5-diamino-1-ethyl-1H-pyrazole-4-carbonitrile typically involves multi-step reactions, including cyclocondensation and functional group transformations. Advanced techniques such as microwave-assisted synthesis and catalyzed reactions have been employed to improve yield and purity, reflecting the broader shift toward green chemistry practices. These innovations resonate with the increasing focus on sustainable manufacturing and waste reduction in the chemical industry.

Analytical characterization of this compound relies on techniques like NMR spectroscopy, mass spectrometry, and HPLC, ensuring compliance with stringent quality standards. Its physicochemical properties, such as melting point and logP, are critical for predicting its behavior in biological systems and industrial applications. These aspects are frequently searched by professionals seeking structure-activity relationship insights or formulation optimization strategies.

As the scientific community continues to explore the potential of 3,5-diamino-1-ethyl-1H-pyrazole-4-carbonitrile, its versatility positions it as a key player in advancing precision medicine and smart materials. With ongoing research into its derivatives and analogues, this compound is poised to contribute to breakthroughs in multiple disciplines, aligning with global trends like personalized therapeutics and circular economy principles.

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