Cas no 727993-37-5 (2-methyl-4-(1H-pyrazol-1-yl)aniline)
2-Methyl-4-(1H-pyrazol-1-yl)aniline is a versatile aromatic amine derivative featuring a pyrazole substituent at the para position relative to the amino group. This compound exhibits unique electronic and steric properties due to the synergistic effects of the electron-donating amino group and the heterocyclic pyrazole moiety. The methyl group at the ortho position enhances steric hindrance, potentially improving selectivity in coordination chemistry applications. As a building block, it demonstrates excellent reactivity in palladium-catalyzed cross-coupling reactions and serves as a valuable precursor for pharmaceuticals, agrochemicals, and functional materials. The pyrazole ring contributes to enhanced metabolic stability in bioactive molecules, while the aniline functionality allows for straightforward derivatization. This compound's balanced lipophilicity and molecular rigidity make it particularly useful in medicinal chemistry for drug discovery programs targeting kinase inhibition.
727993-37-5 structure
Product Name:2-methyl-4-(1H-pyrazol-1-yl)aniline
CAS No:727993-37-5
MF:C10H11N3
MW:173.214441537857
CID:2105378
PubChem ID:14450261
Update Time:2025-07-02
2-methyl-4-(1H-pyrazol-1-yl)aniline Chemical and Physical Properties
Names and Identifiers
-
- 2-methyl-4-(1H-pyrazol-1-yl)benzenamine
- Z419011574
- QJYXYKMDSQIDHK-UHFFFAOYSA-N
- AKOS009471111
- 2-methyl-4-pyrazol-1-ylaniline
- SCHEMBL2191239
- 102792-04-1
- EN300-174601
- G40615
- DB-356164
- CEB99337
- CS-0236873
- 826-939-3
- 2-Methyl-4-(1H-pyrazol-1-yl)aniline
- 727993-37-5
- DA-03242
- 2-methyl-4-(1H-pyrazol-1-yl)aniline
-
- Inchi： 1S/C10H11N3/c1-8-7-9(3-4-10(8)11)13-6-2-5-12-13/h2-7H,11H2,1H3
- InChI Key： QJYXYKMDSQIDHK-UHFFFAOYSA-N
- SMILES： N1(C=CC=N1)C1=CC=C(C(C)=C1)N
Computed Properties
- Exact Mass: 173.095297364Da
- Monoisotopic Mass: 173.095297364Da
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 13
- Rotatable Bond Count: 1
- Complexity: 172
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 1.6
- Topological Polar Surface Area: 43.8?2
2-methyl-4-(1H-pyrazol-1-yl)aniline Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | M642965-25mg |
2-methyl-4-(1H-pyrazol-1-yl)aniline |
727993-37-5 | 25mg |
$ 70.00 | 2022-06-02 | ||
| TRC | M642965-50mg |
2-methyl-4-(1H-pyrazol-1-yl)aniline |
727993-37-5 | 50mg |
$ 95.00 | 2022-06-02 | ||
| TRC | M642965-250mg |
2-methyl-4-(1H-pyrazol-1-yl)aniline |
727993-37-5 | 250mg |
$ 340.00 | 2022-06-02 | ||
| Enamine | EN300-174601-0.05g |
2-methyl-4-(1H-pyrazol-1-yl)aniline |
727993-37-5 | 95% | 0.05g |
$76.0 | 2023-12-05 | |
| Enamine | EN300-174601-0.1g |
2-methyl-4-(1H-pyrazol-1-yl)aniline |
727993-37-5 | 95% | 0.1g |
$113.0 | 2023-12-05 | |
| Enamine | EN300-174601-0.25g |
2-methyl-4-(1H-pyrazol-1-yl)aniline |
727993-37-5 | 95% | 0.25g |
$162.0 | 2023-12-05 | |
| Enamine | EN300-174601-0.5g |
2-methyl-4-(1H-pyrazol-1-yl)aniline |
727993-37-5 | 95% | 0.5g |
$310.0 | 2023-12-05 | |
| Enamine | EN300-174601-1.0g |
2-methyl-4-(1H-pyrazol-1-yl)aniline |
727993-37-5 | 95% | 1g |
$0.0 | 2023-06-08 | |
| Enamine | EN300-174601-2.5g |
2-methyl-4-(1H-pyrazol-1-yl)aniline |
727993-37-5 | 95% | 2.5g |
$810.0 | 2023-12-05 | |
| Enamine | EN300-174601-5.0g |
2-methyl-4-(1H-pyrazol-1-yl)aniline |
727993-37-5 | 95% | 5.0g |
$1199.0 | 2023-02-16 |
2-methyl-4-(1H-pyrazol-1-yl)aniline Related Literature
-
Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
-
Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
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Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
-
Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
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