Cas no 7250-19-3 (1H-Indol-3-amine)

1H-Indol-3-amine, also known as 3-aminoindole, is a heterocyclic organic compound featuring an indole core substituted with an amino group at the 3-position. This structure imparts significant reactivity, making it a valuable intermediate in pharmaceutical and agrochemical synthesis. Its electron-rich aromatic system and nucleophilic amino group enable diverse functionalization, facilitating the production of indole-based derivatives. The compound is particularly useful in the development of bioactive molecules, including serotonin receptor modulators and kinase inhibitors. High purity grades ensure consistent performance in research and industrial applications. Proper handling is advised due to its sensitivity to light and air, which may affect stability.
1H-Indol-3-amine structure
1H-Indol-3-amine structure
Product Name:1H-Indol-3-amine
CAS No:7250-19-3
MF:C8H8N2
MW:132.162521362305
MDL:MFCD03848224
CID:576881
PubChem ID:230280
Update Time:2025-10-31

1H-Indol-3-amine Chemical and Physical Properties

Names and Identifiers

    • 1H-Indol-3-amine
    • 1H-Indol-3-yl amine
    • 3-amino-1H-indole
    • 3-Aminoindol
    • 3-aminoindole
    • Indol-3-ylamin
    • indol-3-ylamine
    • Indole-3-amine
    • Indoleamine
    • NSC 24933
    • 1H-Indol-3-ylaMine HCl
    • SCHEMBL37668
    • 1H-Indole-3-amine
    • NSC-24933
    • FT-0678721
    • DTXSID40282207
    • AM20041082
    • Q27103796
    • CS-0270266
    • EN300-342283
    • CHEBI:28626
    • SCHEMBL2953261
    • SB74221
    • AKOS000302998
    • NSC24933
    • C01819
    • W-203633
    • indolamine
    • F96246
    • 1H-Indol-3-amine, AldrichCPR
    • 7250-19-3
    • MFCD03848224
    • 1H-Indol-3-ylamine
    • MDL： MFCD03848224
    • Inchi： 1S/C8H8N2/c9-7-5-10-8-4-2-1-3-6(7)8/h1-5,10H,9H2
    • InChI Key： TXQAZWIBPGKHOX-UHFFFAOYSA-N
    • SMILES： N1C=C(C2C=CC=CC1=2)N

Computed Properties

  • Exact Mass: 132.06900
  • Monoisotopic Mass: 132.069
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 0
  • Complexity: 124
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 1.9
  • Topological Polar Surface Area: 41.8A^2

Experimental Properties

  • Density: 1.268±0.06 g/cm3 (20 oC 760 Torr),
  • Melting Point: 117 oC
  • Boiling Point: 354°C at 760 mmHg
  • Flash Point: 195°C
  • Refractive Index: 1.757
  • Solubility: Slightly soluble (2.5 g/l) (25 o C),
  • PSA: 41.81000
  • LogP: 2.33130

1H-Indol-3-amine Security Information

  • Hazard Category Code： R22;R36
  • Safety Instruction： S26
  • Hazardous Material Identification： Xn
  • HazardClass：IRRITANT

1H-Indol-3-amine Customs Data

  • HS CODE：2933990090
  • Customs Data：

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

1H-Indol-3-amine Pricemore >>

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1H-Indol-3-amine Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:7250-19-3)1H-Indol-3-amine
Order Number:A962641
Stock Status:in Stock
Quantity:5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 16:14
Price ($):2686.0

1H-Indol-3-amine Related Literature

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Additional information on 1H-Indol-3-amine

Recent Advances in the Study of 1H-Indol-3-amine (CAS: 7250-19-3) in Chemical Biology and Pharmaceutical Research

The compound 1H-Indol-3-amine (CAS: 7250-19-3) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile pharmacological properties and potential therapeutic applications. This research brief aims to synthesize the latest findings on this compound, focusing on its synthesis, biological activities, and emerging applications in drug development.

Recent studies have highlighted the role of 1H-Indol-3-amine as a key intermediate in the synthesis of various bioactive molecules, including indole alkaloids and serotonin receptor modulators. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy in enhancing the binding affinity of serotonin receptor ligands, suggesting potential applications in treating neurological disorders such as depression and anxiety.

In addition to its neurological applications, 1H-Indol-3-amine has shown promise in oncology research. A preclinical study conducted by researchers at the National Cancer Institute revealed that derivatives of this compound exhibit potent anti-proliferative effects against certain cancer cell lines, particularly in breast and prostate cancers. The mechanism of action appears to involve the inhibition of key signaling pathways, such as the PI3K/AKT/mTOR cascade.

From a synthetic chemistry perspective, advancements have been made in the efficient production of 1H-Indol-3-amine. A novel catalytic method utilizing palladium-based catalysts was reported in Organic Letters, achieving higher yields and reduced environmental impact compared to traditional methods. This development is expected to facilitate broader research and industrial applications of the compound.

Despite these promising findings, challenges remain in optimizing the pharmacokinetic properties of 1H-Indol-3-amine derivatives. Current research is focused on structural modifications to improve bioavailability and reduce off-target effects. Collaborative efforts between academic institutions and pharmaceutical companies are underway to translate these discoveries into clinical applications.

In conclusion, 1H-Indol-3-amine (CAS: 7250-19-3) represents a compound of growing importance in chemical biology and drug discovery. Its diverse biological activities and synthetic versatility make it a valuable scaffold for developing new therapeutic agents. Future research directions include exploring its potential in combination therapies and further elucidating its molecular mechanisms of action.

7250-19-3 (1H-Indol-3-amine) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:7250-19-3)1H-Indol-3-amine
A962641
Purity:99%
Quantity:5g
Price ($):2686.0
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