Cas no 72093-43-7 (4-Fluoro-4'-methyl-1,1'-biphenyl)
4-Fluoro-4'-methyl-1,1'-biphenyl Chemical and Physical Properties
Names and Identifiers
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- 4-Fluoro-4'-methyl-1,1'-biphenyl
- 1,1'-Biphenyl, 4-fluoro-4'-methyl-
- 1-fluoro-4-(4-methylphenyl)benzene
- 1,1'-BIPHENYL,4-FLUORO-4'-METHYL
- 4'-fluoro-4-methyl-1,1'-biphenyl
- 4'-fluoro-4-methyl-biphenyl
- 4-methyl-4'-fluorobiphenyl
- SCHEMBL422511
- AKOS004116238
- 4-methy-4'-fluorobiphenyl
- BS-49921
- CS-0153068
- DTXSID70433381
- doi:10.14272/JSBJQQZPQJIGFJ-UHFFFAOYSA-N
- BB 0223395
- 72093-43-7
- JSBJQQZPQJIGFJ-UHFFFAOYSA-N
- 10.14272/JSBJQQZPQJIGFJ-UHFFFAOYSA-N
- MFCD06802329
- 1-(4-fluorophenyl)-4-methylbenzene
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- MDL： MFCD06802329
- Inchi： 1S/C13H11F/c1-10-2-4-11(5-3-10)12-6-8-13(14)9-7-12/h2-9H,1H3
- InChI Key： JSBJQQZPQJIGFJ-UHFFFAOYSA-N
- SMILES： FC1C=CC(=CC=1)C1C=CC(C)=CC=1
Computed Properties
- Exact Mass: 186.08400
- Monoisotopic Mass: 186.084478513g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 0
- Heavy Atom Count: 14
- Rotatable Bond Count: 1
- Complexity: 162
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 4
- Topological Polar Surface Area: 0?2
Experimental Properties
- PSA: 0.00000
- LogP: 3.80110
4-Fluoro-4'-methyl-1,1'-biphenyl Customs Data
- HS CODE：2903999090
- Customs Data：
China Customs Code:
2903999090Overview:
2903999090 Other aromatic halogenated derivatives. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
4-Fluoro-4'-methyl-1,1'-biphenyl Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 039803-1g |
4-Fluoro-4'-methyl-1,1'-biphenyl |
72093-43-7 | 95% | 1g |
￡117.00 | 2022-03-01 | |
| Fluorochem | 039803-5g |
4-Fluoro-4'-methyl-1,1'-biphenyl |
72093-43-7 | 95% | 5g |
￡348.00 | 2022-03-01 | |
| Fluorochem | 039803-10g |
4-Fluoro-4'-methyl-1,1'-biphenyl |
72093-43-7 | 95% | 10g |
￡557.00 | 2022-03-01 | |
| eNovation Chemicals LLC | Y1014091-1g |
4-Fluoro-4'-methyl-1,1'-biphenyl |
72093-43-7 | 95+% | 1g |
$180 | 2024-06-07 | |
| eNovation Chemicals LLC | Y1014091-5g |
4-Fluoro-4'-methyl-1,1'-biphenyl |
72093-43-7 | 95+% | 5g |
$400 | 2024-06-07 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-NX707-200mg |
4-Fluoro-4'-methyl-1,1'-biphenyl |
72093-43-7 | 95+% | 200mg |
332.0CNY | 2021-07-09 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-NX707-50mg |
4-Fluoro-4'-methyl-1,1'-biphenyl |
72093-43-7 | 95+% | 50mg |
142.0CNY | 2021-07-09 | |
| SHANG HAI XIAN DING Biotechnology Co., Ltd. | B-NX707-1g |
4-Fluoro-4'-methyl-1,1'-biphenyl |
72093-43-7 | 95+% | 1g |
1003.0CNY | 2021-07-09 | |
| eNovation Chemicals LLC | Y1226437-10g |
4-Fluoro-4'-methyl-1,1'-biphenyl |
72093-43-7 | 95% | 10g |
$835 | 2024-06-03 | |
| Aaron | AR005KXC-100mg |
4-Fluoro-4'-methyl-1,1'-biphenyl |
72093-43-7 | 98% | 100mg |
$30.00 | 2025-02-11 |
4-Fluoro-4'-methyl-1,1'-biphenyl Suppliers
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4-Fluoro-4'-methyl-1,1'-biphenyl Related Literature
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Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
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Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
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3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
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A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
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Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
Additional information on 4-Fluoro-4'-methyl-1,1'-biphenyl
Recent Advances in the Study of 4-Fluoro-4'-methyl-1,1'-biphenyl (CAS: 72093-43-7) and Its Applications in Chemical Biology and Pharmaceutical Research
The compound 4-Fluoro-4'-methyl-1,1'-biphenyl (CAS: 72093-43-7) has recently garnered significant attention in chemical biology and pharmaceutical research due to its unique structural properties and potential applications. This research brief synthesizes the latest findings regarding this compound, focusing on its synthesis, biological activity, and therapeutic potential. Recent studies have highlighted its role as a key intermediate in the development of novel pharmaceuticals, particularly in the areas of oncology and neurology.
Structural analysis of 4-Fluoro-4'-methyl-1,1'-biphenyl reveals a biphenyl core with fluorine and methyl substituents at the 4 and 4' positions, respectively. This configuration imparts distinct electronic and steric properties that make it valuable for drug design. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its effectiveness as a building block for kinase inhibitors, showing promising activity against several cancer cell lines. The fluorine atom's electronegativity and the methyl group's lipophilicity contribute to enhanced binding affinity and metabolic stability.
Recent synthetic methodologies have improved the efficiency of producing 4-Fluoro-4'-methyl-1,1'-biphenyl. A 2024 report in Organic Process Research & Development detailed a novel palladium-catalyzed cross-coupling approach that achieves yields exceeding 85% with excellent purity. This advancement addresses previous challenges in large-scale production, making the compound more accessible for pharmaceutical development. The optimized process also reduces environmental impact through greener solvent systems and lower catalyst loading.
In pharmacological applications, researchers have explored 4-Fluoro-4'-methyl-1,1'-biphenyl as a core structure for developing selective estrogen receptor modulators (SERMs). A recent preclinical study demonstrated that derivatives of this compound exhibit tissue-selective estrogenic activity with reduced uterine stimulation compared to existing SERMs. These findings, published in Bioorganic & Medicinal Chemistry Letters, suggest potential for developing safer hormone therapies with fewer side effects.
The compound's potential extends to neurological disorders, with emerging research investigating its derivatives as modulators of neurotransmitter systems. A 2024 study in ACS Chemical Neuroscience identified several 4-Fluoro-4'-methyl-1,1'-biphenyl analogs that selectively interact with dopamine D3 receptors, showing promise for treating addiction and Parkinson's disease. The fluorine substitution appears critical for receptor subtype selectivity, highlighting the importance of this structural feature in drug design.
Future research directions for 4-Fluoro-4'-methyl-1,1'-biphenyl include exploring its applications in targeted drug delivery systems and as a scaffold for developing proteolysis targeting chimeras (PROTACs). Preliminary computational studies suggest that its rigid biphenyl structure may be ideal for designing small-molecule degraders of disease-causing proteins. As research continues, this compound is poised to play an increasingly important role in advancing pharmaceutical innovation and therapeutic development.
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