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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines

Research Brief on 2-(Piperidin-3-yl)acetic acid hydrochloride (CAS: 71985-81-4)

2-(Piperidin-3-yl)acetic acid hydrochloride (CAS: 71985-81-4) is a piperidine derivative that has garnered significant attention in the field of chemical biology and medicinal chemistry due to its versatile applications in drug discovery and development. This compound serves as a key intermediate in the synthesis of various bioactive molecules, particularly those targeting the central nervous system (CNS) and other therapeutic areas. Recent studies have explored its potential as a building block for novel pharmacophores, highlighting its importance in modern drug design.

The structural features of 2-(Piperidin-3-yl)acetic acid hydrochloride, including its piperidine ring and carboxylic acid moiety, make it a valuable scaffold for the development of ligands targeting G protein-coupled receptors (GPCRs) and enzymes. Recent research has focused on its role in the synthesis of modulators for neurotransmitter receptors, such as dopamine and serotonin receptors, which are critical in the treatment of neurological and psychiatric disorders. Additionally, its hydrochloride salt form enhances solubility, facilitating its use in various experimental and pharmacological applications.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers utilized 2-(Piperidin-3-yl)acetic acid hydrochloride as a precursor for the development of novel sigma-1 receptor ligands. The study demonstrated that derivatives of this compound exhibited high affinity and selectivity for sigma-1 receptors, which are implicated in neuroprotection and pain modulation. The findings suggest potential applications in the treatment of neurodegenerative diseases and chronic pain conditions.

Another recent investigation, featured in Bioorganic & Medicinal Chemistry Letters, explored the use of 2-(Piperidin-3-yl)acetic acid hydrochloride in the synthesis of dual-acting serotonin and norepinephrine reuptake inhibitors (SNRIs). The researchers reported that the compound's structural flexibility allowed for the optimization of pharmacokinetic properties, leading to improved blood-brain barrier penetration and therapeutic efficacy. This underscores its utility in the design of next-generation antidepressants and anxiolytics.

Beyond its applications in CNS drug discovery, 2-(Piperidin-3-yl)acetic acid hydrochloride has also been investigated for its role in the development of antiviral agents. A 2022 study in Antiviral Research highlighted its incorporation into small-molecule inhibitors targeting viral proteases. The study revealed that the compound's piperidine core contributed to enhanced binding affinity and inhibitory activity against viral replication, offering a promising avenue for the treatment of viral infections.

In conclusion, 2-(Piperidin-3-yl)acetic acid hydrochloride (CAS: 71985-81-4) continues to be a pivotal compound in chemical biology and medicinal chemistry research. Its diverse applications in drug discovery, particularly in the realms of CNS disorders and antiviral therapy, underscore its significance as a versatile building block. Ongoing research is expected to further elucidate its potential and expand its utility in the development of novel therapeutics.

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• 51052-79-0(3-(Piperidin-4-yl)propanoic acid hydrochloride)
• 73415-84-6(2-(4-piperidyl)acetic acid;hydrochloride)
• 1822-31-7(3-(Piperidin-3-yl)propanoic acid)
• 52429-55-7(2-(3-ethylpiperidin-4-yl)acetic Acid;hydrochloride)
• 887587-24-8(2-(3-methyl-4-piperidyl)acetic acid)
• 84512-08-3(4-(Piperidin-4-yl)butanoic acid hydrochloride)
• 71985-82-5(3-(3-piperidyl)propanoic acid;hydrochloride)